Lack of significant estrogenic or antiestrogenic activity of pyrethroid insecticides in three in vitro assays based on classic estrogen receptor α-mediated mechanisms

Toxicological Sciences

Volumn 57, Issue 1, 2000, Pages 54-60

  Saito, K ^a   Tomigahara, Y ^a   Ohe, N ^a   Isobe, N ^a   Nakatsuka, I ^a   Kaneko, H ^a  

^a SUMITOMO CHEMICAL CO LTD   (Japan)

Author keywords

Competitive ligand binding assay; Estrogen receptor; Pyrethroid insecticides; Reporter gene assay; Yeast two hybrid assay

Indexed keywords

4 HYDROXYTAMOXIFEN; ALLETHRIN; ANTIESTROGEN; CIPERMETHRIN; DIETHYLSTILBESTROL; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; FENVALERATE; INSECTICIDE; PERMETHRIN; PHENOTHRIN; PYRETHROID; THYMIDINE KINASE;

ARTICLE; CHEMICAL INTERACTION; CHEMICAL STRUCTURE; ENZYME ACTIVATION; ESTROGEN ACTIVITY; GENE ACTIVATION; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; IN VITRO STUDY; RECEPTOR BINDING; REPORTER GENE;

BINDING, COMPETITIVE; ESTROGEN ANTAGONISTS; ESTROGEN RECEPTOR ALPHA; ESTROGENS, NON-STEROIDAL; GENES, REPORTER; HUMANS; HYBRIDIZATION, GENETIC; INSECTICIDES; LUCIFERASES; PLASMIDS; PYRETHRINS; RECEPTORS, ESTROGEN; YEASTS;

EID: 0033864006     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Stimulation of estrogen receptor-mediated transcription and alteration in the phosphorylation state of the rat uterine estrogen receptor by estrogen, cyclic adenosine monophosphate, and insulin-like growth factor-I
2. Phenol red in tissue culture media is a weak estrogen: Implications concerning the study of estrogen-responsive cells in culture
3. Rapid screening of environmental chemicals for estrogen receptor binding capacity
4. Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300
5. Environmental estrogens: Health implications for humans and wildlife
6. Growth factors in breast cancer
7. Estrogenic and antiprogestagenic activities of pyrethroid insecticides
8. Estrogenic potential of certain pyrethroid compounds in the MCF-7 human breast carcinoma cell line
9. Sequence and expression of human estrogen receptor complementary DNA
10. Estrogenic activity of the insecticide chlordecone (kepone) and interaction with uterine estrogen receptors
11. GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors
12. Estrogenic activity in vivo and in vitro of some diethylstilbestrol metabolites and analogs
13. Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs
14. Bisphenol-A: An estrogenic substance is released from polycarbonate flasks during autoclaving
15. Development of stably transfected estrogen receptor-mediated luciferase reporter gene assay in the human T47D breast cancer cell line
16. The nuclear receptor superfamily: The second decade
17. In vitro bioassays of non-steroidal phytoestrogens
18. Intrinsic estrogenicity of some progestagenic drugs
19. Interaction of naturally occurring nonsteroidal estrogens with expressed recombinant human estrogen receptor
20. Pyrethroids, nerve poisons: How their risks to human health should be assessed
21. Nerve membrane Na+ channels as targets of insecticides
22. New screening methods for chemicals with hormonal activities using interaction of nuclear hormone receptor with coactivator
23. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily
24. Pyrethroids
25. Oestrogen receptor beta (ER beta)
26. Modulation of the ligand-independent activation of the human estrogen receptor by hormone and antihormone
27. The E-SCREEN assay as a tool to identify estrogens: An update on estrogenic environmental pollutants
28. The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function
29. Steroid hormone receptors: Interaction with deoxyribonucleic acid and transcription factors
30. Molecular mechanisms of action of steroid/thyroid receptor superfamily members
31. The E-screen assay: A comparison of different MCF7 cell stocks
32. Expression and regulation of estrogen receptor beta in human breast tumors and cell lines
33. TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors
34. A sensitive bioassay for detection of dietary estrogens in animal feeds
35. Environmentally persistent alkylphenolic compounds are estrogenic
36. In vitro bioassays for assessing estrogenic substances
37. Antiestrogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on 17β-estradiol-induced pS2 expression