Identification of a Borrelia burgdorferi OspA T Cell Epitope That Promotes Anti-OspA IgG in Mice

Journal of Immunology

Volumn 157, Issue 12, 1996, Pages 5496-5502

  Bockenstedt, Linda K ^a   Fikrig, Erol ^a,b   Barthold, Stephen W ^a   Flavell, Richard A ^a,c   Kantor, Fred S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Biomedical Sciences

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; BACTERIAL VACCINE; BACTERIUM ANTIBODY; IMMUNOGLOBULIN G; INTERLEUKIN 4; LIPOPROTEIN; MEMBRANE ANTIGEN; OUTER MEMBRANE PROTEIN; OUTER SURFACE PROTEIN A; PEPTIDE; RECOMBINANT VACCINE;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BIOSYNTHESIS; C3H MOUSE; EPITOPE MAPPING; FEMALE; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MOLECULAR GENETICS; MOUSE; PASSIVE IMMUNIZATION; T LYMPHOCYTE;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; ANTIGENS, SURFACE; BACTERIAL OUTER MEMBRANE PROTEINS; BACTERIAL VACCINES; EPITOPE MAPPING; FEMALE; IMMUNIZATION, PASSIVE; IMMUNOGLOBULIN G; INTERLEUKIN-4; LIPOPROTEINS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C3H; MOLECULAR SEQUENCE DATA; PEPTIDES; T-LYMPHOCYTES; VACCINES, SYNTHETIC;

EID: 0030589292     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Steere, A. C. 1989. Lyme disease. N. Engl. J. Med. 321:586.
2. Bockenstedt, L. K., and S. E. Malawista. 1996. Lyme disease. In Clinical Immunology: Principles and Practice, Vol. 2. R. R. Rich, ed. Mosby Year Book. St. Louis, p. 1234.
3. Simon, M. M., U. E. Schaible, R. Wallich, and M. D. Kramer. 1991. A mouse model for Borrelia burgdorferi infection: approach to a vaccine against Lyme disease. Immunol. Today 12:11.
4. Schaible, U. E., M. D. Kramer, K. Eichmann, M. Modolell, C. Museteanu, and M. M. Simon. 1990. Monoclonal antibodies specific for the outer surface protein A (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice. Proc. Natl. Acad. Sci. USA 87:3768.
5. Fikrig, E., S. W. Barthold, F. S. Kantor, and R. A. Flavell. 1990. Protection of mice against the Lyme disease agent by immunizing with recombinant OspA. Science 250:553.
6. Fikrig, E., S. W. Barthold, N. Marcantonio, K. Deponte, F. S. Kantor, and R. A. Flavell. 1992. Roles of OspA, OspB and flagellin in protective immunity to Lyme borreliosis in laboratory mice. Infect. Immun. 59:553.
7. Preac-Mursic, V., B. Wilske, E. Patsouris, S. Jauris, G. Will, E. Soutschek, S. Rainhardt, G. Lehnert, U. Klockmann, and P. Mehraein. 1992. Active immunization with pC protein of Borrelia burgdorferi protects gerbils against B. burgdorferi infection. Infection 20:342.
8. Nguyen, T.-P. K., T. T. Lam, S. W. Barthold, S. R. Telford III, R. A. Flavell, and E. Fikrig. 1994. Partial destruction of Borrelia burgdorferi within ticks engorged on OspE- or OspF-immunized mice. Infect. Immun. 62:2079.
9. Sears, J. E., E. Fikrig, T. Y. Nakagawa, K. Deponte, N. Marcantonio, F. S. Kantor, and R. A. Flavell. 1991. Molecular mapping of Osp-A mediated immunity against Borrelia burgdorferi, the agent of Lyme disease. J. Immunol. 147:1995.
10. Fikrig, E., S. R. Telford III, R. Wallich, M. Chen, Y. Lobet, F. R. Matuschka, R. B. Kimsey, F. S. Kantor, S. W. Barthold, A. Spielman, and R. A. Flavell. 1995. Vaccination against Lyme discase caused by diverse Borrelia burgdorferi. J. Exp. Med. 181:215.
11. Lengl-Janssen, B., A. F. Strauss, A. C. Steere, and T. Kamradt. 1994. The T helper cell response in Lyme arthritis: differential recognition of Borrelia burgdorferi outer surface protein A in patients with treatment-resistant or treatment-responsive Lyme arthritis. J. Exp. Med. 180:2069.
12. Kamradt, T., B. Lengl-Janssen, A. F. Strauss, G. Bansal, and A. C. Steere. 1996. Dominant recognition of a Borrelia burgdorferi outer surface protein A peptide by T helper cells in patients with treatment-resistant Lyme arthritis. Infect. Immun. 64:1284.
13. Barthold, S. W., D. H. Persing, A. L. Armstrong, R. A. Peeples. 1991. Kinetics of Borrelia burgdorferi dissemination and evolution of disease following intradermal inoculation of mice. Am. J. Pathol. 139:263.
14. Barthold, S. W., C. L. Sidman, and A. L. Smith. 1992. Lyme borreliosis in genetically resistant and susceptible mice with severe combined immunodeficiency. Am. J. Trop. Med. Hyg. 47:605.
15. Barthold, S. W., M. deSouza, and S. Feng. 1996. Serum-mediated resolution of Lyme arthritis in mice. Lab. Invest. 74:57.
16. Barthold, S. W., M. S. deSouza, J. L. Janotka, A. L. Smith, and D. H. Persing. 1993. Chronic Lyme borreliosis in the laboratory mouse. Am. J. Pathol. 143:959.
17. Erdile, L. F., M.-A. Brandt, D. J. Warakomski, G. J. Westrack, A. Sadziene, A. G. Barbour, and J. P. Mays. 1993. Role of attached lipid in immunogenicity of Borrelia burgdorferi OspA. Infect. Immun. 61:81.
18. Barbour, A. G. 1984. Isolation and cultivation of Lyme disease spirochetes. Yale J. Biol. Med. 57:521.
19. Van Noort, J. M., and A. C. M. Van der Drift. 1989. The selectivity of cathepsin D suggests an involvement of the enzyme in the generation of T-cell epitopes. J. Biol. Chem. 264:14159.
20. Van Noort, J. M., J. Boon, A. C. M. Van der Drift, J. P. A. Waganaar, A. M. H. Boots, and C. J. P. Boog. 1991. Antigen processing by endosomal proteases determines which sites of sperm-whale myoglobin are eventually recognized by T cells. Eur. J. Immunol. 21:1989.
21. Dunn, J. J., B. N. Lade, and A. G. Barbour. 1991. Outer surface protein A (OspA) from the Lyme disease spirochete, Borrelia burgdorferi: high level expression and purification of a soluble recombinant form of OspA. Protein Expression Purif. 1:159.
22. Williams, K. R., and K. L. Stone. 1995. In gel digestion of SDS PAGE-separated proteins: observations from internal sequencing of 25 proteins. In Techniques in Protein Chemistry, Vol. 6. J. Crabb, ed. Academic Press, New York, pp. 143-152.
23. Hu-Li, J., J. Ohara, C. Watyson, W. Tsang, and W. E. Paul. 1989. Derivation of a T cell line that is highly responsive to IL-4 and IL-2 (CT.4R) and of an IL-2 hyporesponsive mutant of that line (CT.4S). J. Immunol. 142:800.
24. Rudensky, A. Y., P. Preston-Hurlburt, S.-C. Hong, A. Barlow, and C. A. Janeway, Jr. 1991. Sequence analysis of peptides bound to MHC class II molecules. Nature 353:622.
25. Mosmann, T. R., H. Cherwinski, M. W. Bond, M. A. Giedlin, and R. L. Coffman. 1986. Two types of murine helper T cell clones. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 36:2348.
26. Cher, D. J., and T. R. Mosmann. 1987. Two types of murine helper T cell clones. II. Delayed typed hypersensitivity is mediated by Th1 clones. J. Immunol. 139:3688.
27. Barthold, S. W., E. Fikrig, L. K. Bockenstedt, and D. H. Persing. 1995. Circumvention of outer surface protein A immunity by host-adapted Borrelia burgdorferi. Infect. Immun. 63:2255.
28. Yang, M., and J. Weis. 1993. Borrelia burgdorferi outer surface lipoproteins OspA and OspB possess B-cell mitogenic and cytokine-stimulatory properties. Infect. Immun. 61:3843.
29. Montgomery, R. R., S. E. Malawista, K. J. M. Feen, and L. K. Bockenstedt. 1996. Direct demonstration of antigenic substitution of Borrelia burgdorferi ex vivo: exploration of the paradox of the early immune response to outer surface proteins A and C in Lyme disease. J. Exp. Med. 183:261.
30. Bockenstedt, L. K., R. J. Gee, and M. J. Mamula. 1995. Self-peptides in the initiation of lupus autoimmunity. J. Immunol. 154:3516.
31. Lehmann, P. V., T. Forsthuber, A. Miller, and E. E. Sercarz. 1992. Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature 358:155.
32. Kaufman, D. L., M. Clare-Salzier, J. Tian, T. Forsthuber, G. S. P. Ting, P. Robinson, M. A. Atkinson, and E. E. Sercarz. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature 366:69.
33. Bockenstedt, L. K., E. Fikrig, S. W. Barthold, F. S. Kantor, and R. A. Flavell. 1993. Inability of truncated recombinant OspA proteins to elicited protective immunity to Borrelia burgdorferi in mice. J. Immunol. 151:900.