The role of gag in human immunodeficiency virus type 1 virion morphogenesis and early steps of the viral life cycle

Journal of Virology

Volumn 70, Issue 12, 1996, Pages 8645-8652

  Reicin, Alise S ^a   Ohagen, Asa ^b   Yin, Lei ^a   Hoglund, Stefan ^b   Goff, Stephen P ^a  

^a Columbia University ^*  (United States)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GAG PROTEIN; GENE PRODUCT; VIRUS DNA; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; GENE MUTATION; HUMAN IMMUNODEFICIENCY VIRUS 1; LEUKEMIA CELL LINE; NONHUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; VIRION; VIRUS ASSEMBLY; VIRUS MUTANT; VIRUS PARTICLE; VIRUS REPLICATION;

EID: 0029961364     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.12.8645-8652.1996     Document Type: Article

References (48)

1. Aldovini, A., and M. B. Feinberg. 1990. Transfection of molecularly cloned HIV genomes, p. 166. In A. Aldovini and B. D. Walker (ed.), Techniques in HIV research. Stockton Press, New York.
2. Bennett, R. P., T. D. Nelle, and J. W. Wills. 1993. Functional chimeras of the Rous sarcoma virus and human immunodeficiency virus Gag proteins. J. Virol. 67:6487-6498.
3. Bloomberg, J., and P. Medstrand. 1990. A sequence in the carboxy terminus of the HIV-1 matrix protein is highly similar to sequences in membrane-associated proteins of other RNA viruses: possible functional implications. New Biol. 2:1044-1046.
4. Brown, P. O., B. Bowerman, H. E. Varmus, and J. M. Bishop. 1987. Correct integration of retroviral DNA in vitro. Cell 49:347-356.
5. Bukrinsky, M. I., S. Haggerty, M. P. Dempsey, N. Sharova, A. Adzhubei, L. Spitz, P. Lewis, D. Goldfarb, M. Emerman, and M. Stevenson. 1993. A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells. Nature (London) 365:666-669.
6. Colicelli, J., and S. P. Goff. 1988. Sequence and spacing requirements of a retrovirus integration site. J. Mol. Biol. 199:47-50.
7. Cullen, B. 1987. Use of eukaryotic expression technology in the functional analysis of cloned genes. Methods Enzymol. 152:684-704.
8. Dickson, C., R. Eisenman, H. Fan, E. Hunter, and N. Teich. 1984. Protein biosynthesis and assembly, p. 513-648. In R. Weiss, N. Teich, H. Varmus, and J. Coffin (ed.), RNA tumor viruses, vol. 1. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
9. Dorfman, T., A. Bukovsky, A. Ohagen, S. Hoglund, and H. Gottlinger. 1994. Functional domains of the capsid protein of human immunodeficiency virus type I. J. Virol. 68:8180-8187.
10. Fricks, C. E., and J. M. Hogle. 1990. Cell-induced conformational change in poliovirus: externalization of the amino terminus of VP1 is responsible for liposome binding. J. Virol. 64:1934-1945.
11. Gallay, P., S. Swingler, J. Song, F. Bushman, and D. Trono. 1995. HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase. Cell 83:569-576.
12. Gelderblom, H. R. 1991. Assembly and morphology of HIV: potential effect of structure on viral function. AIDS 5:617-638.
13. Gelderblom, H. R., E. H. Hausmann, M. Ozel, G. Pauli, and M. A. Koch. 1987. Fine structure of the human immunodeficiency virus (HIV) and immunolocalization of structural proteins. Virology 156:171-176.
14. gag virus-like particles from recombinant baculovirus infected insect cells. Cell 59:103-112.
15. Gorelick, R. J., S. M. Nigida, J. R. Bess, L. O. Arthur, L. E. Henderson, and A. Rein. 1990, Noninfectious human immunodeficiency virus type 1 mutants deficient in genomic RNA. J. Virol. 64:3207-3211.
16. Gottlinger, H. G., J. G. Sodroski, and W. A. Haseltine. 1989. Role of capsid precursor processing and myristoylation in morphogenesis and infectivity of human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. USA 86:5781-5785.
17. Haffar, O., J. Garrigues, B. Travis, P. Moran, J. Zarling, and S.-L. Hu. 1990. Human immunodeficiency virus-like, nonreplicating. gag-env particles assemble in a recombinant vaccinia virus expression system. J. Virol. 64:2653-2659.
18. Hoglund, S., L. G. Ofverstedt, A. Nilsson, P. Lundquist, H. Gelderbloom, M. Ozel, and U. Skolund. 1992. Spatial visualization of the maturing HIV-1 core and its linkage to the envelope. AIDS Res. Hum. Retroviruses 8:1-7.
19. Hoglund, S., A. Ohoagen, K. Lawrence, and D. Gabzuda. 1994. Role of vif during packing of the core of HIV-1. Virology 201:349-355.
20. Hsu, H.-W., P. Schwartzberg, and S. Goff. 1985. Point mutations in the P30 domain of the gag gene of the Moloney murine leukemia virus. Virology 142:211-214.
21. Karacostas, V., K. Nagashima, M. A. Gonda, and B. Moss. 1989. Human immunodeficiency virus-like particles produced by a vaccinia expression vector. Proc. Natl. Acad. Sci. USA 86:8964-8967.
22. Kohl, N. E., E. A. Emini, W. A. Schleif, L. J. Davis, J. C. Heimbach, R. A. Dixon, E. M. Scolnick, and I. S. Sigal. 1998. Active human immunodeficiency virus protease is required for viral infectivily. Proc. Natl. Acad. Sci. USA 85:4686-4690.
23. Krausslich, H.-G., M. Facke, A.-M. Heuser, J. Konvalinka, and H. Zentgraf. 1995. The spacer peptide between human immunodeficiency virus capsid and nucleocapsid proteins is essential for ordered assembly and viral infectivity. J. Virol. 69:3407-3419.
24. Liu, H., X. Wu, M. Newman, G. Shaw, B. H. Hahn, and J. C. Kappes. 1995. The vif protein of human and simian immunodeficiency viruses is packaged into virions and associated with viral core structures. J. Virol. 69:7630-7638.
25. Luban, J., K. L. Bossolt, E. K. Franke, G. V. Kalpana, and S. P. Goff. 1993. Human immunodeficiency virus type I gag protein hinds to cyclophilins A and B. Cell 73:1067-1078.
26. Luban, J., C. Lee, and S. P. Goff. 1993. Effect of linker insertion mutations in the human immunodeficiency virus type 1 gag gene on activation of viral protease expressed in bacteria. J. Virol. 67:3630-3634.
27. Mammano, F., A. Ohagen, S. Hoglund, and H. G. Gottlinger. 1994. Role of the major homology region of human immunodeficiency virus type 1 in virion morphogenesis. J. Virol. 68:4927-4936.
28. Mergener, K., M. Facke, R. Welker, V. Brinkmann, H. R. Gelderblom, and H. G. Krausslich. 1992. Analysis of HIV particle formation using transient expression of subviral constructs in mammalian cells. Virology 186:25-39.
29. Park, J., and C. D. Morrow. 1993. Mutations in the protease gene of human immunodeficiency virus type 1 affect release and stability of virus particles. Virology 194:843-8511.
30. Peng, C., B. K. Ho, T. W. Chang, and N. T. Chang. 1989. Role of human immunodeficiency virus type 1-specific protease in core protein maturation and viral infectivity. J. Virol. 63:2550-2556.
31. Pepinsky, R. B. 1983. Localization of lipid-protein and protein-protein interactions within the murine retrovirus gag precursor by a novel peptidemapping technique. J. Biol. Chem. 258:11229-11235.
32. Prasad, V. R., I. Lowy, T. De Los Santos, L. Chiang, and S. P. Goff. 1991. Isolation and characterization of a dideoxyguanosine triphosphate-resistant mutant of human immunodeficiency virus reverse transcriptase. Proc. Natl. Acad. Sci. USA 88:11363-11367.
33. Queen, C., and D. Baltimore. 1983. Immunoglobulin gene transcription is activated by downstream sequence elements. Cell 33:741-748.
34. Ratner, L., W. Haseltine, R. Patarca, K. J. Livak, B. Starcich, S. F. Joseph, E. R. Doran, J. A. Rafalski, E. A. Whitwhoen, K. Baumeister, L. Ivanofff, S. R. Petteway, M. L. Pearson, J. A. Lautenberg, T. S. Papas, J. Ghrayeb, N. T. Chang, R. C. Gallo, and F. Wong-Staal. 1985. Complete nucleotide sequence off the AIDS virus, HTLV-III. Nature (London) 313:277-284.
35. Reicin, A., S. Paik, R. Berkowitz, J. Luban, I. Lowy, and S. Goff. 1995. Linker insertion mutations in the human immunodeficiency virus type 1 gag gene: effects on virion particle assembly, release, and infectivity. J. Virol. 69:642-650.
36. Royer, M., S. S. Hong, B. Gay, M. Cerutti, and P. Boulanger. 1992. Expression and extracellular release of human immunodeficiency virus type 1 Gag precursors by recombinant baculovirus-infected cells. J. Virol. 66:3230-3235.
37. Shioda, A. J., M.-I. Cho, M.-L. Hammarskjold, and D. Rekosh. 1990. Production of human immunodeficiency virus (HIV)-like particles from cells infected with recombinant vaccinia viruses carrying the gag gene of HIV. Virology 175:139-148.
38. gag-pol expressed from a simian virus 40 late replacement vector are efficiently processed and assembled into virus-like particles. J. Virol. 64:2743-2750.
39. Srinivasakumar, N., M.-L. Hammarskjold, and D. Rekosh. 1995. Characterization of deletion mutants in the capsid region of human immunodeficiency virus type 1 that affect particle formation and Gag-Pol precursor incorporation. J. Virol. 69:6106-6114.
40. Stewart, L., G. Schatz, and V. M. Vogt. 1990. Properties of avian retrovirus particles defective in viral protease. J. Virol. 64:5076-5092.
41. Strambio-de-Castillia, C., and E. Hunter. 1992. Mutational analysis of the major homology region of Mason-Pfizer monkey virus by use of saturation mutagenesis. J. Virol. 66:7021-7032.
42. Stromberg, K., N. E. Hurley, N. L. Davis, R. R. Rueckert, and E. Fleissner. 1974. Structural studies of avian myeloblastosis virus: comparison of polypeptides in virion and core component by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. J. Virol. 13:513-528.
43. von Schwedler, U., J. Song, C. Aiken, and D. Trono. 1993. vif is crucial for human immunodeficiency virus type 3 proviral DNA synthesis in infected cells. J. Virol. 67:4945-4955.
44. Wang, C.-T., and E. Barklis. 1993. Assembly, processing, and infectivity of human immunodeficiency virus type 1 Gag mutants. J. Virol. 67:4264-4273.
45. Weldon, R. A. J., and J. W. Wills. 1993. Characterization of a small (25-kilodalton) derivative of the Rous sarcoma virus Gag protein competent for particle release. J. Virol. 67:5550-5561.
46. Wills, J. W., and R. C. Craven. 1991. Form, function, and use of retroviral Gag proteins. AIDS 5:639-654.
47. Yoshinaka, Y., and R. B. Luftig. 1977. Murine leukemia virus morphogenesis: cleavage of P70 in vitro can be accompanied by a shift from a concentrically coiled internal strand ("immature") to a collapsed ("mature") form of the virus core. Proc. Natl. Acad. Sci. USA 74:3446-3450.
48. Yu, X., Q. C. Yu, T. H. Lee and M. Essex. 1992. The C terminus of human immunodeficiency virus type 1 matrix protein is involved in early steps of the virus life cycle. J. Virol. 64:5667-5670.