Update on perinatal hypoxic insult: Mechanism, diagnosis and interventions

European Journal of Paediatric Neurology

Volumn 4, Issue 5, 2000, Pages 203-209

  Amato, Maurizio ^a,c   Donati, Filippo ^a,b,c  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

^c Wildermeth of Biel   (Switzerland)

Author keywords

Brain damage; Hypoxia ischaemia; Therapeutic strategies

Indexed keywords

ALLOPURINOL; AMINO ACID RECEPTOR BLOCKING AGENT; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; CATALASE; CYTOKINE; DEFEROXAMINE; DIZOCILPINE; ENDONUCLEASE; FLUNARIZINE; FREE RADICAL; GLUCOCORTICOID; GLUTAMIC ACID; GLUTAMINE; GLUTATHIONE PEROXIDASE; INDOMETACIN; IRON; LACTIC ACID; MAGNESIUM; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NIMODIPINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PHENOBARBITAL; PHOSPHOLIPASE; PROSTAGLANDIN; PROTEINASE; SCAVENGER; SUPEROXIDE DISMUTASE; UNINDEXED DRUG;

BRAIN HYPOXIA; BRAIN ISCHEMIA; CELL DEATH; COMPUTER ASSISTED TOMOGRAPHY; ELECTROENCEPHALOGRAPHY; HUMAN; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; REVIEW;

EID: 0033858461     PISSN: 10903798     EISSN: None     Source Type: Journal    
DOI: 10.1053/ejpn.2000.0307     Document Type: Review

References (79)

1. Perinatal asphyxia: Clinical aspects
2. Hypoxic-ischemic brain injury in the newborn
3. Neurologic outcome of prematurity
4. Etiological factors associated with the development of periventricular leukomalacia
5. Intrapartum hypoxic-ischemic cerebral injury and subsequent cerebral palsy: Medicolegal issues
6. Cerebral angioarchitecture and perinatal brain lesions in premature and full-term infants
7. Outcomes of extremely low birth weight infants
8. White matter injury in the preterm infants: An important determination of abnormal neurodevelopment outcome
9. Cerebral structure and intracranial hemorrhage in the neonate. A real time ultrasound study
10. Interventions for perinatal hypoxic-ischemic encephalopathy
11. Current and potentially new management strategies for perinatal hypoxic-ischemic encephalopathy
12. Development of cerebrovascular architecture and its relationship to periventricular leukomalacia
13. Ischemia of the preterm brain
14. Outcome of neonatal intraventricular hemorrhage with periventricular echodense lesions
15. Apoptosis in the brains of infants suffering intrauterine cerebral injury
16. Reduced iron-associated antioxidants in premature newborns suffering intracerebral hemorrhage
17. Oxygen derived free radicals in post-ischemic tissue injury
18. Role of xanthine oxidase and its inhibitor in hypoxia: Reoxygenation injury
19. Amniotic fluid interleukin-6: A sensitive test for antenatal diagnosis of acute inflammatory lesions of preterm placenta and prediction of perinatal morbidity
20. Amniotic fluid inflammatory cytokines (interleukin-6, interleukin 1B and tumor necrosis factor-a) neonatal brain white matter lesions and cerebral palsy
21. Maternal intrauterine infection, cytokines and brain damage in the preterm newborn
22. Infection remote from the brain, neonatal white matter damage and cerebral palsy in the preterm infant
23. Brain damage in preterm newborns: Might enhancement of developmentally regulated endogenous protection open a door for prevention?
24. Neonatal cytokines and coagulation factors in children with cerebral palsy
25. Interferons and cerebral palsy
26. Glutamate and the pathophysiology of hypoxic-ischemic brain injury
27. Calcium fluxes, calcium antagonists and calcium related pathology in brain ischemia, hypoglycemia and spreading depression: A unifying hypothesis
28. Prognostic value of serum creatinekinase brain isoenzyme in term babies with perinatal hypoxic injuries
29. Cerebral hypothermia is not neuroprotective when started after postischemic seizures in fetal sheep
30. Neonatal encephalopathies as classified by EEG-sleep criteria: Severity and timing based on clinical/pathologic correlations
31. Characterization and classification of neonatal seizures
32. Prediction of neurological outcome after birth asphyxia from continuous-two channel electroencephalography
33. Prognostic value of background patterns in the neonatal EEG
34. A study of clinical, pathological and electroencephlographic features in 137 full-term babies with a long-term follow-up
35. Amplitude integrated EEG 3 and 6 hours after birth in full-term neonates with hypoxic-ischemic encephalopathy
36. Prognosis of newborn infants with hypoxic-ischemic brain injury assessed by phosphorus magnetic resonance spectroscopy
37. Neurological prognosis of high-risk preterm infants with peri-intraventricular hemorrhage and ventricular dilatation
38. Intracranial duplex Doppler: Practical uses in pediatric neurology and neurosurgery
39. Profound asphyxia in the premature infant: Imaging findings
40. Perinatal asphyxia: MR-findings in the first 10 days
41. Magnetic resonance imaging of the brain in very preterm infants: Visualization of the germinal matrix, early myelination, and cortical folding
42. Quantitative magnetic resonance imaging of brain development in premature and mature newborns
43. Proton magnetic resonance spectroscopy of the brain in normal preterm and term infants, and early changes after perinatal hypoxia-ischemia
44. Quantitation of phosphorus metabolites in newborn human brain using internal water as reference standard
45. Early detection of periventricular leukomalacia by diffusion-weighted magnetic resonance imaging techniques
46. Magnetic resonance imaging of perfusion using spin inversion of arterial water
47. Abnormal magnetic resonance signal in the internal capsule predicts poor developmental outcome in infants with hypoxic-ischemic encephalopathy
48. Does the brain regenerate after perinatal infarction?
49. Predictive value of early neuroimaging, pulsed Doppler and neurophysiology in full term infants with hypoxic-ischaemic encephalopathy
50. Screening in child health
51. Ischemia and reperfusion injury
52. Oxygen radicals in cerebral ischemia
53. Hypoxia-ischemia in the neonatal rat brain: Histopathology after post-treatment with NMDA and non-NMDA receptor antagonists
54. L-arginine infusion promotes nitric oxide dependent vasodilatation, increases cerebral blood flow and reduces infarction volume in the rat
55. Effect of mild hypothermia on cerebral energy metabolism during the evolution of hypoxic-ischemic brain damage in immature rat
56. Oxygen radicals, lipid peroxidation and neutrophil infiltration after small intestine ischemia and reperfusion
57. Allopurinol administered after inducing hypoxia-ischemia reduces brain injury in 7 day old rats
58. Effect of allopurinol on postasphyxial free radical formation, cerebral hemodynamics and electrical brain activity
59. Safety and pharmacokinetics of recombinant human superoxide dismutase administered intratracheally to premature neonates with respiratory distress syndrome
60. Prevention of bronchopulmonary dysplasia by administration of bovine superoxide dismutase in preterm infants with respiratory distress syndrome
61. Glutamate and the pathophysiology of hypoxic-ischemic brain damage
62. Prevention by magnesium of excitotoxic neuronal death in the developing brain. An animal model for clinical intervention studies
63. Mk-801 prevents hippocampal neurodegeneration in neonatal hypoxic-ischemic rats
64. The neuroprotective actions of a calcium channel antagonist flunarizine in the infant rat
65. The use of calcium channel blocker nicardipine for severely asphyxiated newborn infants
66. Reduction of perinatal hypoxic-ischemic injury with deferoxamine treatment during recovery
67. Brain superoxide anion generation in asphyxiated piglets and the effect of indomethacin at therapeutic dose
68. Effects of dexamethasone in hypoxic-ischemic brain injury in the neonatal rat
69. Dexamethasone prevents hypoxic-ischemic brain damage in the neonatal rat
70. Use of barbiturate therapy in severe perinatal asphyxia: A randomized controlled trial
71. The effect of hyperglycemia on cerebral metabolism during hypoxia-ischemia in the immature rat
72. Severe hypocarbia in preterm infants and neurodevelopmental deficit
73. Randomized trial of permissive hypercapnia in preterm infants
74. Hyperbilirubinemia, hypocarbia and periventricular leukomalacia in preterm infants: Relationship to cerebral palsy
75. Carbon dioxide protects the perinatal brain from hypoxic-ischemic damage. An experimental study in the immature rat
76. Influence of mild hypothermia on hypoxic-ischemic brain damage in the immature rat
77. Posthypoxic cooling of neonatal rats provides protection against brain injury
78. Selective head cooling in newborn infants after perinatal asphyxia: A safety study
79. Neuroprotection with prolonged head cooling started before postischemic seizures in fetal sheep