Serotonergic function, behavioral disinhibition, and negative affect in children of alcoholics: The moderating effects of puberty

Alcoholism: Clinical and Experimental Research

Volumn 24, Issue 7, 2000, Pages 972-979

  Twitchell, Geoffrey R ^a   Hanna, Gregory L ^b   Cook, Edwin H ^c   Fitzgerald, Hiram E ^a   Zucker, Robert A ^b  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

Behavioral Disinhibition; Biological Markers; Children of Alcoholics; Negative Affect; Whole Blood Serotonin (5 HT)

Indexed keywords

SEROTONIN;

ADOLESCENT; AFFECT; AGE; AGGRESSION; ALCOHOLISM; ANXIETY; ARTICLE; BEHAVIOR DISORDER; CHILD BEHAVIOR; CHILD DEVELOPMENT; CONTROLLED STUDY; DEPRESSION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PREPUBERTY; PRIORITY JOURNAL; PUBERTY; RISK FACTOR; SCHOOL CHILD; SEROTONIN BLOOD LEVEL; SEROTONINERGIC TRANSMISSION; SOCIAL STATUS;

ADOLESCENT; ADOLESCENT BEHAVIOR; ALCOHOLISM; ANALYSIS OF VARIANCE; CHILD; CHILD BEHAVIOR; CHILD OF IMPAIRED PARENTS; FEMALE; HUMANS; MALE; PROSPECTIVE STUDIES; PUBERTY; SEROTONIN;

EID: 0033854475     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2000.tb04639.x     Document Type: Article

References (71)

1. Achenbach TM (1991) Manual for the Child Behavior Checklist/4-18 and 1991 Profile. University of Vermont Department of Psychiatry, Burlington, VT.
2. American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders. 3rd ed, rev. American Psychiatric Association, Washington, DC.
3. Anderson GM, Teff KL, Young SN (1984) Effect of a meal on human whole blood serotonin. Gastroenterology 88:86-89.
4. Anderson GM, Young JG, Cohen DJ, Schlicht KR (1981) Liquid Chromatographic determination of serotonin and tryptophan in whole blood and plasma. Clin Chem 27:775-776.
5. Badcock NR, Spence JG, Stern LM (1987) Blood serotonin levels in adults, autistic and nonautistic children with a comparison of different methodologies. Ann Clin Biochem 24:625-634.
6. Biegon A, Greuner N (1992) Age-related changes in serotonin 5-HT2 receptors on human blood platelets. Psychopharmacology 108:210-212.
7. Birmaher B, Stanley M, Greenhill L, Twomey J, Gavrilescu A, Rabinovich H (1990) Platelet imipramine binding in children and adolescents with impulsive behavior. J Am Acad Child Adolesc Psychiatry 29:914-918.
8. Brewerton RD, Flament MR, Rapoport JL, Murphy DL (1993) Seasonal effects on platelet 5-HT content in patients with OCD and controls. Arch Gen Psychiatry 50:409.
9. Brown GL, Linnoila MI (1990) CSF serotonin metabolite (5-HIAA) studies in depression, impulsivity, and violence. J Clin Psychiatry 51:31-41.
10. Castellanos FX, Elia J, Kruesi MJP, Gulotta CS, Mefford IN, Potter WZ, Ritchie GF, Rapoport JL (1994) Cerebrospinal fluid monoamine metabolites in boys with attention-deficit hyperactivity disorder. Psychiatry Res 52:305-316.
11. 2A receptor binding. Neuropsychopharmacology 16:211-216.
12. Cook EH, Anderson GM, Heninger G, Fletcher KE, Freedman DX, Leventhal BL (1981) Tryptophan loading in hyperserotonemic and normoserotonemic adults. Biol Psychiatry 31:525-528.
13. Cook EH, Stein MA, Ellison T, Unis AS, Leventhal BL (1995) Attention deficit hyperactivity disorder and whole blood serotonin levels: Effects of comorbidity. Psychiatry Res 57:13-20.
14. Ernouf D, Compagnon P, Lothion P, Narcisse G, Benard JY, Daoust M (1993) Platelet 3H 5-HT uptake in descendants from alcoholic patients: A potential risk factor for alcohol dependence. Life Sci 52:989-995.
15. Feighner J, Robins E, Guze S, Woodruff R, Winokur G, Munoz R (1972) Diagnostic criteria for use in psychiatric research. Arch Gen Psychiatry 26:57-63.
16. Fils-Aime M, Eckardt M, George D, Brown G, Mefford M, Linnoila M (1996) Early-onset alcoholics have lower CSF 5-HIAA than late-onset alcoholics. Arch Gen Psychiatry 53:211-216.
17. Fitzgerald HE, Sullivan LA, Ham HP, Zucker RA, Bruckel S, Schneider AM (1993) Predictors of behavior problems in three-year-old sons of alcoholics: Early evidence for the onset of risk. Child Dev 64:110-123.
18. Fitzgerald HE, Zucker RA, Yang H-Y (1995) Developmental systems theory and alcoholism: Analyzing patterns of variation in high-risk families. Psychol Addict Behav 9:8-22.
19. Gabel S, Stadler J, Bjorn J, Shindledecker R, Bowden C (1993) Dopamine-beta-hydroxylase in behaviorally disturbed youth: Relationships between teacher and parent ratings. Biol Psychiatry 34:434-442.
20. Halperin JM, Newcorn JH, Schwartz ST, Sharma V, Siever LJ, Koda VJ, Gabriel S (1997) Age-related changes in the association between serotonergic function and aggression in boys with ADHD. Biol Psychiatry 41:682-689.
21. Halperin JM, Sharma V, Siever LJ, Schwartz ST, Matier K, Wornell G, Newcorn JH (1994) Serotonergic function in aggressive and nonaggressive boys with attention deficit hyperactivity disorder. Am J Psychiatry 151:243-248.
22. Hanna G, Yuwiler A, Coates JK (1995) Whole blood serotonin and disruptive behaviors in juvenile obsessive-compulsive disorder. J Am Acad Child Adolesc Psychiatry 34:28-35.
23. Higley JD, Suomi SJ, Linnoila M (1996) A nonhuman primate model of type II excessive alcohol consumption: Part 1. Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration and diminished social compe7 tence correlated with excessive alcohol consumption. Alcohol Clin Exp Res 20:629-642.
24. Hunter JE, Gerbing DW (1982) Unidimensional measurement, second order factor analysis, and causal models, in Research in organizational behavior (Staw B ed), pp 267-320. JAI, Greenwich, CT.
25. Insel TR, Winslow JT (1998) Serotonin neuropeptides in affiliative behaviors. Biol Psychiatry 44:207-219.
26. Jansen RE, Fitzgerald HE, Ham HP, Zucker RA (1995) Pathways into risk: Temperament and behavior problems in three- to five-year-old sons of alcoholics. Alcohol Clin Exp Res 19:501-509.
27. Kaufman J, Birmaher B, Perel J, Dahl RE, Stull S, Brent D, Trubnick L, Al-Shabbout M, Ryan ND (1998) Serotonergic functioning in depressed abused children: Clinical and familial correlates. Biol Psychiatry 44:973-981.
28. Knutson B, Wolkowitz OM, Cole SW, Chan T, Moore EA, Johnson RC, Terpstra J, Turner RA, Reus VI (1998) Selective alteration of personality and social behavior by serotonergic intervention. Am J Psychiatry 155:373-379.
29. Kremer HPH, Goekoop JG, Van Kempen GMJ (1990) Clinical use of the determination of serotonin in whole blood. J Clin Psychopharmacol 10:83-87.
30. Kruesi MJP, Hibbs ED, Zahn TP, Keysor CS, Hamburger SD, Bartko JJ, Rapoport JL (1992) A 2-year prospective follow-up study of children and adolescents with disruptive behavior disorders: Prediction by cerebrospinal fluid 5-hydroxyindoleacetic acid, homovanillic acid, and autonomic measures. Arch Gen Psychiatry 49:429-435.
31. Kruesi MJP, Rapoport JL, Hamburger S, Hibbs E, Potter WZ, Lenane M, Brown GL (1990) Cerebrospinal fluid monoamine metabolites, aggression, and impulsivity in disruptive behavior disorders of children and adolescents. Arch Gen Psychiatry 47:419-426.
32. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer DH, Murphy DL (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science (Wash. DC) 274:1527-1531.
33. Lesch KP, Mossner R (1998) Genetically driven variation in serotonin uptake: Is there a link to affective spectrum, neurodevelopmental, and neurodegenerative disorders? Biol Psychiatry 44:179-192.
34. Lesch KP, Wolozin BL, Murphy DL, Riederer P (1993) Primary structure of the human platelet serotonin uptake site: Identity with the brain 5-HT transporter. J Neurochem 60:2319-2322.
35. Lidow MS, Goldman-Rakic PS, Rakic P (1991) Synchronized overproduction of neurotransmitter receptors in diverse regions of the primate cerebral cortex. Proc Nat Acad Sci USA 88:10218-10221.
36. Linnoila M, Virkkunen M, Sheinin M, Nuutila A, Rimon R, Goodwin FK (1983) Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from non-inpulsive violent behavior. Life Sci 33:2609-2614.
37. Lucki I (1998) The spectrum of behaviors influenced by serotonin. Biol Psychiatry 44:151-162.
38. Maguin E (1991) Evaluation of a community program for the prevention of conduct problems among preschool sons of alcoholic fathers. Unpublished doctoral dissertation, Michigan State University, East Lansing.
39. Maguin E, Zucker RA, Fitzgerald HE (1994) The path to alcohol problems through conduct problems: A family-based approach to very early intervention with risk. J Res Adolesc 4:249-269.
40. Mazzanti CM, Lappalainen J, Long JC, Bengel D, Naukkarinen H, Eggert M, Virkkunen M, Linnoila M, Goldman D (1998) Role of the serotonin transporter promoter polymorphism in anxiety-related traits. Arch Gen Psychiatry 55:936-940.
41. McBride PA, Anderson GM, Hertzig ME, Snow ME, Thompson SM, Khait VD, Shapiro T, Cohen DJ (1998) Effects of diagnosis, race, and puberty on platelet serotonin levels in autism and mental retardation. J Am Acad Child Adolesc Psychiatry 37:767-776.
42. Mehlman PT, Higley JD, Faucher I, Lilly AA, Taub DM, Vickers J, Suomi SJ, Linnoila M (1995) Correlations of CSF 5-HIAA concentration with sociality and the timing of emigration in free-ranging primates. Am J Psychiatry 152:907-913.
43. Moffitt TE (1993) Adolescence-limited and life-course-persistent antisocial behavior: A developmental taxonomy. Psychol Rev 100:674-701.
44. Moffitt TE, Brammer GL, Caspi A, Fawcett JP, Raleigh M, Yuwiler A, Silva P (1998) Whole blood serotonin relates to violence in an epidemiological sample. Biol Psychiatry 43:446-457.
45. Morris NM, Udry JR (1980) Validation of a self-administered instrument to assess stage of adolescent development. J Youth Adolesc 9:271-280.
46. Pine DS, Coplan JD, Wasserman GA, Miller LS, Fried JE, Davies M, Cooper TB, Greenhill L, Shaffer D, Parsons B (1997) Neuroendocrine response to fenfluramine challenge in boys: Associations with aggressive behavior and adverse rearing. Arch Gen Psychiatry 54:839-846.
47. 2A) receptor characteristics and parenting factors for boys at risk for delinquency: Preliminary report. Am J Psychiatry 153:538-544.
48. Pliszka SR, Rogeness GA, Renner P, Sherman J, Broussard R (1988) Plasma neurochemistry in juvenile offenders. J Am Acad Child Adolesc Psychiatry 27:588-594.
49. Puttler LI, Zucker RA, Fitzgerald HE, Bingham CR (1998) Behavioral outcomes among children of alcoholics during the early and middle childhood years: Familial subtype variations. Alcohol Clin Exp Res 22:1962-1972.
50. Raleigh MJ, Brammer GL, McGuire MT, Yuwiler A (1985) Dominant social status facilitates the behavioral effects of serotonergic agonists. Brain Res 348:274-282.
51. Rausch JL, Monteiro MG, Schuckit MA (1991) Platelet serotonin uptake in men with family histories of alcoholism. Neuropsychopharmacology 4:83-86.
52. Regier DA, Farmer ME, Raw DS, Locke BZ, Keith SJ, Judd LL, Goodwin FK (1990) Comorbidity of mental disorders with alcohol and other drug abuse. JAMA 264:2511-2518.
53. Ritvo ER, Yuwiler A, Geller E, Plotkin S, Mason A, Saegar K (1971) Maturational changes in blood serotonin levels and platelet counts. Biochem Med 5:90-96.
54. Rogeness GA, Hernandez JM, Macedo CA, Mitchell EL (1982) Biochemical differences in children with conduct disorder socialized and undersocialized. Am J Psychiatry 139:307-311.
55. Ryan ND, Birmaher B, Perel JM, Dahl RE, Meyer V, Al-Shabbout M, Lyenger S, Puig-Antich J (1992) Neuroendocrine response to L-5Hydroxytryptophan challenge in prepubertal major depression. Arch Gen Psychiatry 49:843-851.
56. Sander T, Harms H, Lesch KP, Dufeu P, Kuhn S, Hoehe M, Rommel-spacher H, Schmidt LG (1997) Association analysis of a regulatory variation of the serotonin transporter gene with severe alcohol dependence. Alcohol Clin Exp Res 21:1356-1359.
57. Sher, KJ (1991) Children of alcoholics: A critical appraisal of theory and research. The University of Chicago Press, Chicago, IL.
58. Sher, KJ (1997) Psychological characteristics of children of alcoholics. Alcohol Health Res World 21:247-254.
59. Stevens G, Featherman DL (1981) A revised socioeconomic index of occupational status. 10:364-395.
60. 3H)-imipramine binding sites on platelets of conduct-disordered children. Neuropsychopharmacology 1:55-62.
61. Twitchell GR, Hanna GL, Cook EH, Fitzgerald HE, Little KY, Zucker RA (1998) Overt behavior problems and serotonergic function in middle childhood among male and female offspring of alcoholic fathers. Alcohol Clin Exp Res 22:1340-1348.
62. Unis AS, Cook EH, Vincent JG, Gjerde KD, Perry BD, Mason C, Mitchell J (1997) Platelet serotonin measures in adolescents with conduct disorder. Biol Psychiatry 42:553-559.
63. Virkkunen M, Eggert M, Rawlings R, Linnoila M (1996) A prospective follow-up study of alcoholic violent offenders and fire setters. Arch Gen Psychiatry 53:523-529.
64. Whitaker-Azmitia PM, Shemer AV, Caruso J, Molino L, Azmitia EC (1990) Role of high affinity serotonin receptors in neuronal growth. Ann N Y Acad Sci 600:315-330.
65. Yuwiler A, Brammer GL, Morley JE, Raleigh MJ, Flannery JW, Geller E (1981) Short-term and repetitive administration of oral tryptophan in normal men. Arch Gen Psychiatry 38:619-626.
66. Zucker RA (1987) The four alcoholisms: A developmental account of the etiologic process, in Nebraska Symposium on Motivation: Alcohol and Addictive Behaviors (Rivers PC ed), pp 27-83. University of Nebraska Press, Lincoln, NE.
67. Zucker RA (2000) Alcohol involvement over the life course, in Tenth Special Report to the U.S. Congress on Alcohol and Health (AH10). National Institute on Alcohol Abuse and Alcoholism, Rockville, MD (in press).
68. Zucker RA, Chermack ST, Curran GM (2000) Alcoholism: A lifespan perspective on etiology and course, in Handbook of developmental psychology (Sameroff A, Lewis A, Miller S eds). Plenum Press, New York (in press).
69. Zucker RA, Ellis DA, Bingham CR, Fitzgerald HE (1996) The development of alcoholic subtypes: Risk variation among alcoholic families during the early childhood years. Alcohol Health Res World 20:46-54.
70. Zucker RA, Ellis DA, Fitzgerald HE, Bingham CR, Sanford DP (1997) Other evidence for at least two alcoholisms: II. Life course variation in antisociality and heterogeneity of alcoholic outcome. Dev Psychopathol 8:831-848.
71. Zucker RA, Fitzgerald HE (1991) Early developmental factors and risks for alcohol problems. Alcohol Health Res World 15:18-22.