Actin-based motility of pathogens: The Arp2/3 complex is a central player

Cellular Microbiology

Volumn 2, Issue 3, 2000, Pages 195-205

  Cossart, P ^a  

^a INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ACTIN DEPOLYMERIZING FACTOR; ALPHA ACTININ; ARP 2 3 COMPLEX; BACTERIAL PROTEIN; COFILIN; GUANINE NUCLEOTIDE BINDING PROTEIN; POLYPEPTIDE; PROFILIN; UNCLASSIFIED DRUG;

ACTIN FILAMENT; ACTIN POLYMERIZATION; BACTERIAL GENE; BACTERIAL TRANSLOCATION; ESCHERICHIA COLI; LISTERIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; SHIGELLA; SHORT SURVEY; VACCINIA VIRUS;

ACTIN-RELATED PROTEIN 2; ACTIN-RELATED PROTEIN 3; ACTINS; BACTERIA; BACTERIAL INFECTIONS; BACTERIAL PHYSIOLOGY; CYTOSKELETAL PROTEINS; HUMANS; MOVEMENT;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; EUKARYOTA; LISTERIA; MAMMALIA; SHIGELLA; VACCINIA; VACCINIA VIRUS;

EID: 0033853186     PISSN: 14625814     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1462-5822.2000.00053.x     Document Type: Short Survey

References (84)

1. Relationship between Arp2/3 complex and the barbed ends of actin filaments at the leading edge of carcinoma cells after epidermal growth factor stimulation
2. SCAR, a WASP related protein isolated as a suppressor of receptors defects in late Dictyostelium development
3. Identification of icsA, a plasmid locus of Shigella flexneri that governs bacterial intra- and intercellular spread through interaction with F- actin
4. Actin polymerization: Where the WASP stings
5. Motility of ActA protein-coated microspheres driven by actin polymerization
6. Aromatic and basic residues within the EVH1 domain of VASP specify its interaction with proline-rich ligands
7. Actin depolymerizing factor (ADF/cofilin) enhances the rate of filament turnover: Implication in actin-based motility
8. Control of actin dynamics in cell motility
9. Inducible recruitment of Cdc42 or WASP to a cell-surface receptor triggers actin polymerisation and filopodium formation
10. A focal adhesion factor directly linking intracellularly motile Listeria monocytogenes and Listeria ivanovii to the actin-based cytoskeleton of mammalian cells
11. Actin and phosphoinositide binding by the ActA protein of the bacterial pathogen Listeria monocytogenes
12. Actin-based motility of vaccinia virus
13. Identification of cofilin, coronin, Rac and capZ in actin tails using a Listeria affinity approach
14. Isolation of a novel gene mutated in Wiskott-Aldrich syndrome
15. Synergy between profilin and actin depolymerizing factor (ADF/cofilin) in enhancing actin filament turnover
16. Intact alpha-actinin molecules are needed for both the assembly of actin into tails and the locomotion of Listeria monocytogenes inside infected cells
17. A novel bacterial gene in Listeria monocytogenes required for host cell microfilament interaction with homology to the proline-rich region of vinculin
18. Intracellular pathogens and the actin cytoskeleton
19. The actin-based motility of intracellular Listeria monocytogenes is not controlled by small GTP-binding proteins of the Rho- and Ras-subfamilies
20. Activation of CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by the Arp2/3 complex and bacterial actin- based motility
21. Targeting of Listeria monocytogenes ActA protein to the plasma membrane as a tool to dissect both actin-based cell morphogenesis and ActA function
22. Actin-based motility of vaccinia virus mimics tyrosine kinase signalling
23. Tyrosine phosphorylation is required for actin based motility of vaccinia but not Listeria or Shigella
24. Shigella actin-based motility in the absence of vinculin
25. Shigella flexneri surface protein IcsA is sufficient to direct actin- based motility
26. Structural and functional similarities between the human cytoskeletal protein zyxin and the ActA protein of Listeria monocytogenes
27. A novel cellular activator of the Arp2/3 complex: A possible link between actin assembly and endocytosis
28. iactA of Listeria ivanovii, although distantly related to Listeria monocytogenes actA, restores actin tail formation in an L. monocytogenes actA mutant
29. A comparative study of the actin-based motilities of the pathogenic bacteria Listeria monocytogenes, Shigella flexneri and Rickettsia conorii
30. Dynamics of actin-based movement by Rickettsia rickettsii in Vero cells
31. Influence of the C-terminus of Wiskott-Aldrich Syndrome Protein (WASp) and the Arp2/3 complex on actin polymerization
32. Cdc42-induced actin filaments are protected from capping proteins
33. Myosin I, Arp2/3, CapZ and a 116 kDa leucine rich repeat (LRR) protein are present in a complex critical for the formation of actin rich extensions
34. Enteropathogenic E. coli acts through WASP and Arp2/3 complex to form pedestals
35. Listeria monocytogenes-induced actin assembly requires the actA gene product, a surface protein
36. The unrelated surface proteins ActA of Listeria monocytogenes and IcsA of Shigella flexneri are sufficient to confer actin-based motility on Listeria innocua and Escherichia coli respectively
37. The actin polymerization protein from Listeria ivanovii is a large repeat protein which shows only limited amino-acid sequence homology to ActA from Listeria monocytogenes
38. Vinculin proteolysis unmasks an ActA homolog for actin-based Shigella motility
39. The amino-terminal part of ActA is critical for the actin-based motility of Listeria monocytogenes; the central proline-rich region acts as a stimulator
40. Identification of two regions in the amino-terminal domain of ActA involved in the actin comet tail formation by Listeria monocytogenes
41. Role of proteins of the Ena/VASP family in Actin-based motility of Listeria monocytogenes
42. Direct involvment of type I myosins in Cdc42-dependent actin polymerization and cytoskeletal polarisation
43. virG, a plasmid-coded virulence gene of Shigella flexneri identification of the virG protein and determination of the complete coding sequence
44. Reconstitution of actin based-based motility of Listeria and Shigella using pure proteins
45. Corequirement of specific phosphoinositides and small GTP-binding protein Cdc42 in inducing actin assembly in Xenopus egg extracts
46. The Arp2/3 complex mediates actin polymerisation induced by the small GTP-binding protein Cdc42
47. Purification of a cortical complex containing two unconventional actins from Acanthamoeba by affinity chromatography on profilin-agarose
48. Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins
49. Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex
50. The Arp2/3 complex: A multifunctional actin organizer
51. Scar, a WASP-related protein, activates nucleation of actin filaments by the Arp2/3 complex
52. Actin-based movement of Listeria monocytogenes: Actin assembly results from the local maintenance of uncapped filament barbed ends at the bacterium surface
53. The Arp2/3 complex is essential for the actin-based motility of Listeria monocytogenes
54. N-WASP, a novel actin depolymerizing protein regulates the cortical cytoskeletal rearrangement in a PIP2 dependent manner downstream of tyrosine kinases
55. Cdc42 is required for membrane dependent actin polymerization in vitro
56. Rho family GTPases control entry of Shigella flexneri into epithelial cells but not intracellular motility
57. ActA is a dimer
58. Structure, subunit topology, and actin binding activity of the Arp2/3 complex from Acanthamoeba
59. The interaction of Arp2/3 complex with actin: Nucleation, high affinity pointed end capping, and formation of branching networks of filaments
60. Structure and function of the Arp2/3 complex
61. Rho-family GTPases require the Arp2/3 complex to stimulate actin polymerization in Acanthamoeba extracts
62. The ancient regulatory-protein family of WD-repeat proteins
63. A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family
64. LaXp180, a mammalian ActA-binding protein, identified with the yeast two-hybrid system, co-localizes with the intracellular Listeria monocytogenes
65. The ActA protein of Listeria monocytogenes acts as a nucleator inducing reorganization of the actin cytoskeleton
66. Waltzing with WASP
67. The interaction between N-WASP and the Arp2/3 complex links Cdc42- dependent signals to actin assembly
68. Xenopus actin-depolymerizing factor/cofilin (XAC) is responsible for the turnover of actin filaments in Listeria monocytogenes tails
69. Interactions between Vaccinia virus IEV membrane proteins and their roles in IEV assembly and actin tail formation
70. Novel form of actin-based motility transports bacteria on the surfaces of infected cells
71. Asymmetric distribution of the Listeria monocytogenes ActA protein is required and sufficient to direct actin-based motility
72. The tandem repeat domain in the Listeria monocytogenes ActA protein controls the rate of actin-based motility, the percentage of moving bacteria and the localization of vasodilator-stimulated phosphoprotein and profilin
73. Listeria monocytogenes ActA protein interacts with phosphatidylinositol 4,5-Bisphosphate in vitro
74. Functional analysis of Shigella VirG domains essential for interaction with vinculin and actin-based motility
75. Neural Wiskott-Aldrich syndrome protein is implicated in the actin- based motility of Shigella flexneri
76. Arp2/3 complex and actin depolymerizing factor/cofilin in dendritic organization and treadmilling of actin filament array in lamellipodia
77. Involvement of profilin in the actin-based motility of L. monocytogenes in cells and in cell-free extracts
78. The world according to Arp: Regulation of actin nucleation by the Arp2/3 complex
79. Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes
80. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filaments assembly
81. Interaction of human Arp2/3 complex and the Listeria monocytogenes ActA protein in actin filament nucleation
82. The complex containing actin-related proteins Arp2 and Arp3 is required for the motility and integrity of actin patches
83. Activation of the yeast Arp2/3 complex by Bee1p, a WASP-family protein
84. The Wiskott-Aldrich syndrome protein directs actin-based motility by stimulating actin nucleation with the Arp2/3 complex