Basic mechanisms of secretion: Sorting into the regulated secretory pathway

Biochemistry and Cell Biology

Volumn 78, Issue 3, 2000, Pages 181-191

  Blazquez, M ^a   Shennan, K I J ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Lipid rafts; Regulated secretory pathway; Secretion; Sorting receptors; Sorting signals; trans Golgi network

Indexed keywords

CELL GRANULE; CONFERENCE PAPER; GOLGI COMPLEX; HUMAN; NEUROSECRETORY CELL; NONHUMAN; PROTEIN AGGREGATION; PROTEIN LIPID INTERACTION; PROTEIN SECRETION; PROTEIN TARGETING; REGULATORY MECHANISM;

EID: 0033851201     PISSN: 08298211     EISSN: None     Source Type: Journal    
DOI: 10.1139/o00-010     Document Type: Conference Paper

References (100)

1. Sorting of gp80 (GPIII, clusterin), a marker protein for constitutive apical secretion in Madin-Darby canine kidney (MDCK) cells, into the regulated pathway in the pheochromocytoma cell line PC12
2. Phasic release of newly synthesized secretory proteins in the unstimulated rat exocrine pancreas
3. Sorting and storage during secretory granule biogenesis: Looking backward and looking forward
4. Regulated and constitutive protein targeting can be distinguished by secretory polarity in thyroid epithelial cells
5. Protein discharge from immature secretory granules displays both regulated and constitutive characteristics
6. N-glycans mediate the apical sorting of a GPI-anchored, raft-associated protein in Madin-Darby canine kidney cells
7. Processing of human prosomatostatin in AtT-20 cells: S-28 and S-14 are generated in different secretory pathways
8. A protease processing site is essential for prorenin sorting to the regulated secretory pathway
9. ER-associated and proteasome-mediated protein degradation: How two topologically restricted events came together
10. Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface
11. Sorting and secretion of adrenocorticotropin in a pituitary tumor cell line after perturbation of the level of a secretory granule-specific proteoglycan
12. Secretory granule targeting of atrial natriuretic peptide correlates with its calcium-mediated aggregation
13. A mutant human proinsulin is secreted from islets of Langerhans in increased amounts via an unregulated pathway
14. Similarities and differences among neuroendocrine, exocrine, and endocytic vesicles
15. Passive sorting in maturing granules of AtT-20 cells: The entry and exit of salivary amylase and proline-rich protein
16. Immunoglobulin-derived polypeptides enter the regulated secretory pathway in AtT-20 cells
17. Milieu-induced, selective aggregation of regulated secretory proteins in the trans-Golgi network
18. Reduction of the disulfide bond of chromogranin B (secretogranin I) in the trans-Golgi network causes its missorting to the constitutive secretory pathways
19. The disulphide bond in chromogranin B, which is essential for its sorting to secretory granules, is not required for its aggregation in the trans-Golgi network
20. A biosynthetic regulated secretory pathway in constitutive secretory cells
21. Targeting of pro-opiomelanocortin to the regulated secretory pathway may involve cooperation between different protein domains
22. Secretory granule content proteins and the luminal domains of granule membrane proteins aggregate in vitro at mildly acidic pH
23. Identification of a sorting signal for the regulated secretory pathway at the N-terminus of pro-opiomelanocortin
24. Identification of the sorting signal motif within pro-opiomelanocortin for the regulated secretory pathway
25. Carboxypeptidase E is a regulated secretory pathway sorting receptor: Genetic obliteration leads to endocrine disorders in Cpe(fat) mice
26. Identification of a transferable sorting domain for the regulated pathway in the prohormone convertase PC2
27. Prodynorphin processing by proprotein convertase 2 - Cleavage at single basic residues and enhanced processing in the presence of carboxypeptidase activity
28. Mechanism of acidification of the trans-golgi network (TGN) - In situ measurements of ph using retrieval of TGN38 and furin from the cell surface
29. Differential distribution of mannose-6-phosphate receptors and furin in immature secretory granules
30. Carboxypeptidase E
31. Microdomains of GPI-anchored proteins in living cells revealed by crosslinking
32. The primary structure of human secretogranin II, a widespread tyrosine-sulfated secretory granule protein that exhibits low pH- and calcium-induced aggregation
33. Traffic, polarity, and detergent solubility of a glycosylphosphatidylinositol-anchored protein after LDL-deprivation of MDCK cells
34. The endoplasmic reticulum as a protein-folding compartment
35. Clathrin and adaptors
36. Formation of the insulin-containing secretory granule core occurs within immature beta-granules
37. The granin (chromogranin/secretogranin) family
38. Proinsulin targeting to the regulated pathway is not impaired in carboxypeptidase E-deficient cpe(fat)/cpe(fat) mice
39. The propeptide of prohormone convertase PC2 acts as a transferable aggregation and membrane-association signal
40. Protein translocation at the ER membrane: A complex process becomes more so
41. Mouse procathepsin L lacking a functional glycosylation site is properly folded, stable, and secreted by NIH 3T3 cells
42. Identification of the secretory vesicle membrane binding region of chromogranin A
43. Pathways of protein secretion in eukaryotes
44. Storage and release of neurotransmitters
45. Structure and function of the mannose 6-phosphate/insulin-like growth factor II receptors
46. Essential role of the disulfide-bonded loop of chromogranin B for sorting to secretory granules is revealed by expression of a deletion mutant in the absence of endogenous granin synthesis
47. Protein targeting via the 'constitutive-like' secretory pathway in isolated pancreatic islets: Passive sorting in the immature granule compartment
48. Distinct molecular mechanisms for protein sorting within immature secretory granules of pancreatic beta-cells
49. Differential sorting of lysosomal enzymes out of the regulated secretory pathway in pancreatic β-cells
50. Raft association of SNAP receptors acting in apical trafficking in Madin-Darby canine kidney cells
51. Neuronal polarity: Essential role of protein-lipid complexes in axonal sorting
52. Dithiothreitol treatment of Madin-Darby canine kidney cells revesibly blocks export from the endoplasmic reticulum but does not affect vectorial targeting of secretory proteins
53. Protein secretion: Puzzling receptors
54. Evidence for polarization of plasma membrane domains in pancreatic endocrine cells
55. The integrity of the RRGDL sequence of the proprotein convertase PC1 is critical for its zymogen and C-terminal processing and for its cellular trafficking
56. Chloroquine diverts ACTH from a regulated to a constitutive secretory pathway in AtT-20 cells
57. Expressing a human proinsulin cDNA in a mouse ACTH-secreting cell. Intracellular storage, proteolytic processing, and secretion on stimulation
58. Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity
59. Retention and retrieval in the endoplasmic reticulum and the Golgi apparatus
60. Biosynthesis of lysosomal cathepsins B and H cultured rat hepatocytes
61. Biosynthesis and processing of lysosomal cathepsin L in primary cultures of rat hepatocytes
62. Depletion of carboxypeptidase E, a regulated secretory pathway sorting receptor, causes misrouting and constitutive secretion of proinsulin and proenkephalin, but not chromogranin A
63. Macro- and micro-domains in the endocrine pancreas
64. Direct identification of prohormone conversion site in insulin-secreting cells
65. The trans-most cisternae of the Golgi complex: Compartment for sorting of secretory and plasma membrane proteins
66. Identification of molecular aggregates containing glycoproteins III, J, K (carboxypeptidase H), and H (Kex2-related proteases) in the soluble and membrane fractions of adrenal medullary chromaffin granules
67. Chromogranin B (secretogranin I), a secretory protein of the regulated pathway, is also present in a tightly membrane-associated form in PC12 cells
68. Trafficking, targeting and translocation of the insulin-responsive glucose transporter, GLUT4, in adipocytes
69. Polarity of epithelial and neuronal cells
70. An antibody against secretogranin I (chromogranin B) is packaged into secretory granules
71. Biosynthesis of lysosomal hydrolases; their synthesis in bound polysomes and the role of co- and post-translational processing in determining their subcellular distribution
72. Mechanisms of intracellular protein transport
73. Selective packaging of human growth hormone into synaptic vesicles in a rat neuronal (PC12) cell line
74. Freeze-fracture and thin-section study of condensing vacuoles in rat pancreatic acinar cells
75. Intracellular misrouting and abnormal secretion of adrenocorticotropin and growth hormone in cpefat mice associated with a carboxypeptidase E mutation
76. Calcium- and pH-dependent aggregation and membrane association of the precursor of the prohormone convertase PC2
77. The structural and functional organisation of intramolecular chaperones: The N-terminal propeptides which mediate protein folding
78. Functional rafts in cell membranes
79. Lipid sorting in epithelial cells
80. Differential extractability of influenza virus hemagglutinin during intracellular transport in polarized epithelial cells and nonpolar fibroblasts
81. Mutations in the pro-peptide of PC2 prevent transit through the secretory pathway
82. Sorting of PC2 to the regulated secretory pathway in AtT20 cells
83. Signal-mediated sorting of membrane proteins between the endoplasmic reticulum and the Golgi apparatus
84. The disulfide-bonded loop of chromogranins, which is essential for sorting to secretory granules, mediates homodimerization
85. Protein secretion: Puzzling receptors
86. Biogenesis of secretory granules in the trans-Golgi network of neuroendocrine and endocrine cells
87. Sorting of progeny coronavirus from condensed secretory proteins at the exit from the trans-Golgi network of AtT20 cells
88. Characterization of the immature secretory granule, an intermediate in granule biogenesis
89. Beta-cell lines derived from transgenic cpe(fat)/cpe(fat) mice are defective in carboxypeptidase E and proinsulin processing
90. GPI-anchored proteins are organized in submicron domains at the cell surface
91. Processing of proinsulin by transfected hepatoma (FAO) cells
92. 3H injection
93. Proteasome-dependent endoplasmic reticulum-associated protein degradation: An unconventional route to a familiar fate
94. The rate of bulk flow from the endoplasmic reticulum to the cell surface
95. pH-dependent binding of chromogranin B and secretory vesicle matrix proteins to the vesicle membrane
96. pH-dependent association of chromogranin A with secretory vesicle membrane and a putative membrane binding region of chromogranin A
97. 2+-induced conformational change and aggregation of chromogranin A
98. Mechanisms and functional features of polarized membrane traffic in epithelial and hepatic cells
99. Proteolytic processing in the secretory pathway
100. Internal cleavage of the inhibitory 7B2 carboxyl-terminal peptide by PC2: A potential mechanism for its inactivation