메뉴 건너뛰기




Volumn 6, Issue 1, 2000, Pages 47-56

Megakaryocyte growth and development factor (MGDF): An Mpl ligand and cytokine that regulates thrombopoiesis

Author keywords

MGDF; Platelet function; Recombinant protein; Thrombopoiesis

Indexed keywords

COMPLEMENTARY DNA; CYTOKINE; MEGAKARYOCYTE GROWTH AND DEVELOPMENT FACTOR; RECOMBINANT PROTEIN;

EID: 0033849494     PISSN: 13684736     EISSN: None     Source Type: Journal    
DOI: 10.1080/13684730050515912     Document Type: Review
Times cited : (22)

References (80)
  • 1
    • 0028343099 scopus 로고
    • Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor mpl
    • (1994) Cell , vol.77 , pp. 1117-1124
    • Bartley, T.D.1    Bogenberger, J.2    Hunt, P.3
  • 2
    • 0029035989 scopus 로고
    • Purification and biologic characterization of plasma-derived megakaryocyte growth and development factor
    • (1995) Blood , vol.86 , pp. 540-547
    • Hunt, P.1    Li, Y.S.2    Nichol, J.L.3
  • 3
    • 0029046966 scopus 로고
    • Megakaryocyte growth and development factor. Analyses of in vitro effects on human megakaryopoiesis and endogenous serum levels during chemotherapy-induced thrombocytopenia
    • (1995) J Clin Invest , vol.95 , pp. 2973-2978
    • Nichol, J.L.1    Hokom, M.M.2    Hornkohl, A.3
  • 4
    • 0029022246 scopus 로고
    • Recombinant human megakaryocyte growth and development factor (rHuMGDF), a ligand for c-mpl, produces functional human platelets in vitro
    • (1995) Stem Cells , vol.13 , pp. 317-322
    • Choi, E.S.1    Hokom, M.2    Bartley, T.3
  • 6
    • 0029062371 scopus 로고
    • Recombinant human megakaryocyte growth and development factor stimulates thrombocytopoiesis in normal nonhuman primates
    • (1995) Blood , vol.86 , pp. 54-59
    • Farese, A.M.1    Hunt, P.2    Boone, T.3
  • 7
    • 10344235968 scopus 로고    scopus 로고
    • Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer
    • (1996) Lancet , vol.348 , pp. 1279-1281
    • Basser, R.L.1    Rasko, J.E.2    Clarke, K.3
  • 8
    • 17944389931 scopus 로고    scopus 로고
    • Randomized, blinded, placebo-controlled phase 1 trial of pegylated recombinant human megakaryocyte growth and development factor with filgrastim after dose-intensive chemotherapy in patients with advanced cancer
    • (1997) Blood , vol.89 , pp. 3118-3128
    • Basser, R.L.1    Rasko, J.2    Clarke, K.3
  • 9
    • 0031049879 scopus 로고    scopus 로고
    • Effects of polyethylene glycol-conjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer
    • (1997) N Engl J Med , vol.336 , pp. 404-409
    • Fanucchi, M.1    Glaspy, J.2    Crawford, J.3
  • 12
    • 4243837805 scopus 로고    scopus 로고
    • Cyclic thrombocytopenia with platelet auto-antibodies: Response to PEG-rHuMegakaryocyte growth and development factor
    • Abst 3757
    • (1998) Blood , vol.92
    • Rice, L.1    Nichol, J.L.2    Delavari, M.3
  • 13
    • 0023220592 scopus 로고
    • Purification and properties of a megakaryocyte stimulatory factor present both in the serum-free conditioned medium of human embryonic kidney cells and in thrombocytopenic plasma
    • (1987) J Biol Chem , vol.262 , pp. 3262-3268
    • Tagrien, G.1    Rosenberg, R.D.2
  • 14
  • 18
    • 0025674093 scopus 로고
    • A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors
    • (1990) Cell , vol.63 , pp. 1137-1147
    • Souyri, M.1    Vigon, I.2    Penciolelli, J.F.3
  • 25
    • 0029030356 scopus 로고
    • The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit
    • (1995) Blood , vol.85 , pp. 2720-2730
    • Kuter, D.J.1    Rosenberg, R.D.2
  • 26
    • 0001940059 scopus 로고    scopus 로고
    • Regulation of platelet production
    • Thrombopoiesis and Thrombopoietins: Molecular, Cellular, Preclinical, and Clinical Biology (ed DJ Kuter, P Hunt, W Sheridan, D Zucker-Franklin). The Humana Press, Totowa, NJ
    • (1997) , pp. 377-395
    • Kuter, D.J.1
  • 28
    • 0028803099 scopus 로고
    • Pegylated megakaryocyte growth and development factor abrogates the lethal thrombocytopenia associated with carboplatin and irradiation in mice
    • (1995) Blood , vol.86 , pp. 4486-4492
    • Hokom, M.M.1    Lacey, D.2    Kinstler, O.B.3
  • 31
    • 0000765321 scopus 로고    scopus 로고
    • The thrombopoietin receptor, Mpl, and signal transduction
    • Thrombopoiesis and Thrombopoietins: Molecular, Cellular, Preclinical, and Clinical Biology (ed DJ Kuter, P Hunt, W Sheridan, D Zucker-Franklin).The Humana Press, Totowa, NJ
    • (1997) , pp. 257-270
    • Kaushansky, K.1    Broudy, V.C.2    Drachman, J.G.3
  • 32
    • 0028827190 scopus 로고
    • Thrombopoietin, c-Mpl ligand, induces tyrosine phosphorylation of Tyk2, JAK2, and STAT3, and enhances agonists-induced aggregation in platelet in vitro
    • (1995) FEBS Lett , vol.374 , pp. 48-52
    • Ezumi, Y.1    Takayama, H.2    Okuma, M.3
  • 33
    • 0029052479 scopus 로고
    • Recombinant thrombopoietin induces rapid protein tyrosine phosphorylation of Janus kinase 2 and Shc in human blood platelets
    • (1995) Blood , vol.86 , pp. 23-27
    • Miyakawa, Y.1    Oda, A.2    Druker, B.J.3
  • 36
  • 38
    • 0025870265 scopus 로고
    • Recombinant human interleukin 6 is a potent inducer of the acute phase response and elevates the blood platelets in nonhuman primates
    • (1991) Exp Hematol , vol.19 , pp. 688-696
    • Mayer, P.1    Geissler, K.2    Valent, P.3
  • 40
    • 0027397921 scopus 로고
    • Recombinant human interleukin-11 stimulates megakaryocytopoiesis and increases peripheral platelets in normal and splenectomized mice
    • (1993) Blood , vol.81 , pp. 901-908
    • Neben, T.Y.1    Loebelenz, J.2    Hayes, L.3
  • 44
    • 1842365251 scopus 로고    scopus 로고
    • Genetic manipulation of Mpl ligand and thrombopoietin in vivo
    • Thrombopoiesis and Thrombopoietins: Molecular, Cellular, Preclinical and Clinical Biology (ed DJ Kuter, P Hunt, W Sheridan, D Zucker-Franklin). The Humana Press, Totowa, NJ
    • (1997) , pp. 349-356
    • De Sauvage, F.J.1    Moore, M.W.2
  • 46
    • 0025936411 scopus 로고
    • Phase I trial of recombinant human interleukin-1 beta alone and in combination with myelosuppressive doses of 5-fluorouracil in patients with gastrointestinal cancer
    • (1991) Blood , vol.78 , pp. 1420-1427
    • Crown, J.1    Jakubowski, A.2    Kemeny, N.3
  • 50
    • 0028961058 scopus 로고    scopus 로고
    • Thrombopoietic effects and toxicity of interleukin-6 in patients with ovarian cancer before and after chemotherapy: A multicentric placebo-controlled randomized phase Ib study
    • (1996) Blood , vol.85 , pp. 2347-2353
    • D'Hondt, V.1    Humblet, Y.2    Guillaume, T.3
  • 52
    • 9244234420 scopus 로고    scopus 로고
    • A randomized placebo-controlled trial of recombinant human interleukin-11 in cancer patients with severe thrombocytopenia due to chemotherapy
    • (1996) Blood , vol.87 , pp. 3607-3614
    • Tepler, I.1    Elias, L.2    Smith, J.W.3
  • 57
  • 58
    • 0028022980 scopus 로고
    • The appearance of a megakaryocyte growth-promoting activity, megapoietin, during acute thrombocytopenia in the rabbit
    • (1994) Blood , vol.84 , pp. 1464-1472
    • Kuter, D.J.1    Rosenberg, R.D.2
  • 61
    • 0028273187 scopus 로고
    • Recombinant human interleukin 11 stimulates multilineage hematopoietic recovery in mice after myelosuppressive regimen of sublethal irradiation and carboplatin
    • (1994) Blood , vol.93 , pp. 1499-1506
    • Leonard, J.P.1    Quintoi, C.M.2    Kozita, M.K.3
  • 64
    • 0028843848 scopus 로고
    • Chronic exposure to retroviral vector encoded MGDF (Mpl-ligand) induces lineage-specific growth and differentiation of megakaryocytes in mice
    • (1995) Blood , vol.86 , pp. 4025-4033
    • Yan, X.Q.1    Lacey, D.2    Fletcher, F.3
  • 65
    • 0029963122 scopus 로고    scopus 로고
    • Combined administration of recombinant human megakaryocyte growth and development factor and granulocyte colony-stimulating factor enhances multilineage hematopoietic reconstitution in nonhuman primates after radiation-induced marrow aplasia
    • (1996) J Clin Invest , vol.97 , pp. 2145-2151
    • Farese, A.M.1    Hunt, P.2    Grab, L.B.3
  • 66
    • 0028302739 scopus 로고
    • Effect of recombinant human interleuki-6 (rhLL-6) and rhLL-3 on hematopoietic regeneration as demonstrated in a nonhuman primate chemotherapy model
    • (1994) Blood , vol.84 , pp. 65-73
    • Winton, E.F.1    Srinivasiah, J.2    Kim, B.K.3
  • 68
    • 0031019748 scopus 로고    scopus 로고
    • Prevention of thrombocytopenia and neutropenia in a non-human primate model of marrow suppressive chemotherapy by combining pegylated recombinant human megakaryocyte growth and development factor and recombinant human granulocyte colony-stimulating factor
    • (1997) Blood , vol.89 , pp. 155-165
    • Harker, L.A.1    Marzec, U.M.2    Kelly, A.B.3
  • 69
    • 0029943307 scopus 로고    scopus 로고
    • Dose-response effects of pegylated human megakaryocyte growth and development factor on platelet production and function in nonhuman primates
    • (1996) Blood , vol.88 , pp. 511-521
    • Harker, L.A.1    Marzec, U.M.2    Hunt, P.3
  • 70
    • 0029080417 scopus 로고
    • Recombinant human megakaryocyte growth and development factor (MGDF) moderately enhances ex vivo platelet aggregation by a receptor dependent mechanism
    • (1995) Thromb Res , vol.80 , pp. 23-33
    • Toombs, C.F.1    Young, C.H.2    Glaspy, J.A.3
  • 72
    • 10344238601 scopus 로고    scopus 로고
    • Administration of pegylated recombinant human megakaryocyte growth and development factor to humans stimulates the production of functional platelets that show no evidence of in vivo activation
    • (1996) Blood , vol.88 , pp. 3288-3298
    • O'Malley, C.J.1    Rasko, J.E.2    Basser, R.L.3
  • 73
    • 9044236159 scopus 로고    scopus 로고
    • Randomised trial of filgrastim-mobilised peripheral blood progenitor cell transplantation versus autologous bone-marrow transplantation in lymphoma patients
    • (1996) Lancet , vol.347 , pp. 353-357
    • Schmitz, N.1    Linch, D.C.2    Dreger, P.3
  • 74
    • 0002504610 scopus 로고    scopus 로고
    • Serum levels of thrombopoietin in health and disease
    • Thrombopoiesis and Thrombopoietins: Molecular, Cellular, Preclinical, and Clinical Biology (ed DJ Kuter, P Hunt, W Sheridan, D Zucker-Franklin). Humana Press, Totowa, NJ
    • (1997) , pp. 359-376
    • Nichol, J.L.1
  • 75
  • 78
    • 0002357056 scopus 로고    scopus 로고
    • Effect of a single dose of pegylated human recombinant megakaryocyte growth and development factor (PEG-rHuMGDF) on platelet counts: Implication for platelet apheresis
    • (1997) Transfusion , vol.37
    • Tomita, D.1    Petrarca, M.2    Paine, T.3
  • 79
  • 80
    • 0008265357 scopus 로고    scopus 로고
    • Cell therapy in peripheral stem cell transplantation: The development of cell isolation techniques
    • Stem Cell Transplantation: A Clinical Textbook (ed PC Buchsel, PM Kapustay) 9-1-9-16. Oncology Nursing Press, Pittsburgh
    • (2000)
    • Foote, M.A.1    Gringeri, A.J.2    Mazanet, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.