Immune regulation: Susceptibility and resistance to autoimmunity

Immunologic Research

Volumn 21, Issue 2-3, 2000, Pages 239-246

  Lo, D ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Asthma; Diabetes; Inflammation; Thymus; Tolerance

Indexed keywords

CHEMOKINE;

ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CELLULAR IMMUNITY; DIABETES MELLITUS; DISEASE PREDISPOSITION; DISEASE RESISTANCE; HUMAN; IMMUNOREGULATION; NONHUMAN; PANCREAS ISLET; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TISSUE SPECIFICITY;

EID: 0033847085     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1385/IR:21:2-3:239     Document Type: Article

References (44)

1. Identity of cells that imprint H-2-restricted T-cell specificity in the thymus
2. T cell specificity in twice-irradiated F1 → parent bone marrow chimeras: Failure to detect a role for immigrant marrow-derived cells in imprinting intrathymic H-2 restriction
3. Discrimination between thymic epithelial cells and peripheral antigen presenting cells in the induction of immature T cell differentiation
4. Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex
5. Thymic cortical epithelium is sufficient for the development of mature T cells in RelB-deficient mice
6. Induction of MHC-restricted specificity and tolerance in the thymus
7. The effect of thymus environment on T cell development and tolerance
8. Clonal deletion of Vβ5+ T cells by transgenic I-E restricted to thymic medullary epithelium
9. B7 expression on thymic medullary epithelium correlates with epithelium mediated deletion ofVβ5+ thymocytes
10. Expression of RelB is required for the development of thymic medulla and dendritic cells
11. Thymocytes and RelB-dependent medullary epithelial cells provide respectively growth-promoting and organization signals to thymic medullary stromal cells
12. Thymic stromal cell specialization and the T cell receptor repertoire
13. Antigen presenting cells in adoptively transferred and spontaneous diabetes
14. A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity
15. On the various manifestations of spontaneous autoimmune diabetes in rodent models
16. Targeted gene knockouts: Insights into dendritic cell biology
17. RelB is essential for the development of myeloid-related CD8α- but not of lymphoid-related CD8β+ dendritic cells
18. DNA immunization in RelB-deficient mice discloses a role for dendritic cells in IgM→IgGl switch in vivo
19. The density of the class II MHC T cell receptor ligand influences IFN-γ/IL-4 ratios in immune responses in vivo
20. The influence of lymphocytes on the presence and organization of dendritic cell subsets in the spleen
21. Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells
22. Antigen presenting function of class II MHC expressing pancreatic beta cells
23. Tolerance in transgenic mice expressing class II MHC on pancreatic acinar cells
24. T-cell tolerance by clonal anergy in transgenic mice with nonlymphoid expression of MHC class II I-E
25. Antigen presentation in MHC class II transgenic mice: Stimulation versus tolerization
26. Peripheral tolerance to an islet cell specific hemagglutinin transgene affects both CD4+ and CD8+ T cells
27. CD8+ T cell-mediated spontaneous diabetes in neonatal mice
28. Peripheral tolerance in transgenic mice: Tolerance to class II MHC and non-MHC transgene antigens
29. C-Maf promotes Th2 and attenuates Th1 differentiation by both IL-4 dependent and independent mechanisms
30. T cell production of an inducible transgene IL-10 provides limited protection from autoimmune diabetes
31. Transgenic expression of Ly-49A in thymocytes permits positive selection of forbidden clones
32. How do monoclonal antibodies induce tolerance? A role for infectious tolerance?
33. Protection against diabetes by MHC heterozygosity and reversal by cyclophosphamide
34. Ability of a non-depleting anti-CD4 antibody to inhibit Th2 responses and allergic lung inflammation is independent of co-receptor function
35. RelB regulation of chemokine expression modulates local inflammation
36. RelB modulation of IκBα stability as a mechanism of transcription suppression of IL-1α, IL-1β, and TNFα in fibroblasts
37. Integrating innate and adaptive immunity in the whole animal
38. Th2 induced eotaxin expression and eosinophilia coexist with Th1 responses at the effector stage of lung inflammation
39. Effects of Th2 cytokines on chemokine expression in the lung: IL-13 potently induces eotaxin expression by lung epithelial cells
40. Identification of a new mouse β-chemokine, TCA-4, with activity on T lymphocytes and mesangial cells
41. Cutting Edge: Ectopic expression of the chemokine TCA4/SLC is sufficient to trigger lymphoid neogenesis
42. Mapping genes regulating lymphocyte function: Correlations with autoimmunity?
43. Thymic skewing of the CD4/CD8 ratio maps with the T cell receptor α-chain locus
44. Preferential expression of TCR Vα regions in CD4/CD8 subsets: Class discrimination or co-receptor recognition?