Expression of bcl-2 oncoprotein in benign and malignant spindle cell tumors of soft tissue, skin, serosal surfaces, and gastrointestinal tract

American Journal of Surgical Pathology

Volumn 22, Issue 7, 1998, Pages 863-872

  Suster, Saul ^a,d   Fisher, Cyril ^b   Moran, Cesar A ^c   Rywlin, Arkadi M ^d  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^c ARMED FORCES INSTITUTE OF PATHOLOGY   (United States)

^d MOUNT SINAI MEDICAL CENTER   (United States)

Author keywords

bcl 2; CD34; Dendritic fibromyxolipoma; Dermatofibrosarcoma protuberaris; Gastrointestinal stromal tumor; Kaposi's sarcoma; Soft tissue sarcoma; Solitary fibrous tumor; Spindle cell lipoma; Spindle cell tumors; Synovial sarcoma

Indexed keywords

CD34 ANTIGEN; PROTEIN BCL 2;

ARTICLE; DERMATOFIBROMA; DERMATOFIBROSARCOMA PROTUBERANS; DIFFERENTIAL DIAGNOSIS; FASCIITIS; FIBROMATOSIS; GASTROINTESTINAL CARCINOMA; GENE EXPRESSION; HUMAN; HUMAN TISSUE; KAPOSI SARCOMA; MAJOR CLINICAL STUDY; NERVE SHEATH TUMOR; PROTO ONCOGENE; SKIN CARCINOMA; SOFT TISSUE SARCOMA; SPINDLE CELL CARCINOMA; SYNOVIAL SARCOMA;

ANTIGENS, CD34; DIAGNOSIS, DIFFERENTIAL; GASTROINTESTINAL NEOPLASMS; HUMANS; IMMUNOENZYME TECHNIQUES; NEOPLASMS, CYSTIC, MUCINOUS, AND SEROUS; PROTO-ONCOGENE PROTEINS C-BCL-2; RETROSPECTIVE STUDIES; SKIN NEOPLASMS; SOFT TISSUE NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 0031847132     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000478-199807000-00008     Document Type: Article

References (49)

1. Aiba S, Tabata N, Ishii H, et al. Dermatofibrosarcoma protuberans is a unique fibrohistiocytie tumor expressing CD34. Br J Cancer 1992;127:79-84.
2. Alsabeth R, Wilson CS, Ahn CW, Vasef MA, Battifora H. Expression of bcl-2 by breast cancer: a possible diagnostic application. Mod Pathol 1996;9:439-44.
3. Arber DA, Kandalaft PL, Mehta P, Battifora H. Vimentin negative epithelioid sarcoma: the value of an immunohistochemical panel that includes CD34. Am J Surg Pathol 1993;17:302-7.
4. Baer R. Bcl-2 breathes life into embryogenesis, Am J Pathol 1994; 145:7-10.
5. Baretton GB, Diebold J, Christoforis G, et al. Apoptosis and immunohistochemical bcl-2 expression in colorectal adenomas and carcinomas. Aspects of carcinogenesis and prognostic significance. Cancer 1996;77:255-64.
6. Brathwaite C, Suster S. Dermatofibrosarcoma protuberans. A critical reappraisal of the role of immunohistochemical stains for diagnosis. Appl Immunohistochem 1994;2:36-41.
7. Caux C, Dezutter-Dambuyant C, Schmitt D, Banchereau J. GMCSF and TNF-2 cooperate in the generation of dendritic Langerhans cells. Nature 1992;360:258-61.
8. Chen F-F, Van J-J, Jin Y-T, Su I-J. Selection of bcl-2 and p53 in thymoma: Expression of bcl-2 as a marker of tumor aggressiveness. Hum Pathol 1996;27:1089-92.
9. Chen-Woan M, Delaney CP, Fournier V, et al. A new protocol for the propagation of dendritic cells from rat bone marrow using recombinant GM-CSF, and their quantification using the mAb OX62. J Immunol Meth 1995;178:157-71.
10. Chieng DC, Ross TS, Ambros RA. Bcl-2 expression and the development of endometrial carcinoma. Mod Pathol 1996;9:402-6.
11. Chilosi M, Facchetti F, Dei Tos AP, et al. Bcl-2 expression in pleural and extrapleural solitary fibrous tumors. J Pathol 1997; 181:362-7.
12. Cohen PR, Rapini RP, Farhood AI. Expression of the human hematopoietic progenitor cell antigen CD34 in vascular and spindle cell tumors. J Cutan Pathol 1993;20:15-20.
13. Dada MA, Chetty R, Biddolph SC, Schneider JW, Gatter KC. The immunoexpression of bcl-2 and p53 in Kaposi's sarcoma. Histopathology 1996;29:159-63.
14. Fina L, Molgaard HV, Robertson D, et al. Expression of the CD34 gene in vascular endothelial cells. Blood 1990;75:2417-26.
15. Flohil CC, Janssen PA, Bosman FT. Expression of bcl-2 protein in hyperplastic polyp, adenomas and carcinomas of the colon. J Pathol 1996;178:393-7.
16. Henriksen R, Wilander E, Oberg K. Expression and prognostic significance of bcl-2 in ovarian tumors. Br J Cancer 1995;72:1324-9.
17. Hirakawa N, Naka T, Yamamoto I, Fukuda T, Tsuneyoshi M. Overexpression of bcl-2 protein in synovial sarcoma: a comparative study of other soft tissue spindle cell sarcomas and an additional analysis by fluorescence in-situ hybridization. Hum Pathol 1996;27:1060-5.
18. Hockenbery D, Nuñez G, Milliman C, Schriber RD, Korsmeyer SJ. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 1990;348:334-6.
19. Hockenbery DM, Zutter M, Hickey W, Nahm M, Korsmeyer SJ. Bcl-2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci USA 1991;88:6961-5.
20. Inaba K, Inaba M, Romani N, et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med 1992;176:1693-702.
21. Joensun H, Pylkkanen L, Toikkanen S. Bcl-2 protein expression and long-term survival in breast cancer. Am J Pathol 1994;145: 1191-8.
22. Korsmeyer SJ. Bel 2 initiates a new category of oncogenes: regulators of cell death. Blood 1992;80:879-86.
23. Le Brun DP, Warnke RA, Cleary ML. Expression of bcl-2 in fetal tissues suggests a role in morphogenesis. Am J Pathol 1993;142: 743-53.
24. Lu QL, Elia G, Lucas S, Thomas JA. Bcl-2 proto-oncogene expression in Epstein Barr-virus associated nasopharyngeal carcinoma. Int J cancer 1993;53:29-35.
25. Lu QL, Abel P, Foster CS, Lalani E-N. Bcl-2: role in epithelial differentiation and oncogenesis. Hum Pathol 1996;27:102-10.
26. Miettinen M, Lindenmayer AE, Chaubal A. Endothelial cell markers CD31, CD34, and BNH9 antibody to H- and Y- antigens. Evaluation of their specificity and sensitivity in the diagnosis of vascular tumors and comparison with von Willebrand factor. Mod Pathol 1994; 7:82-9.
27. Mikhael AI, Bacchi CE, Zarbo RJ, Ma CK, Gown AM. CD34 expression in stromal tumors of the gastrointestinal tract. Appl Immunohistochem 1994; 2:89-93.
28. Morris CB, Gendelman R, Marrogi AJ, et al. Immunohistochemical detection of bcl-2 in AIDS-associated and classical Kaposi's sarcoma. Am J Pathol 1996;148:1055-63.
29. Nakamura T, Nornuma S, Sakai T, Nariya S. Expression of bcl-2 oncoprotein in gastro intestinal and uterine carcinomas and their premalignant lesions. Hum Pathol 1997; 28: 309- 315.
30. Nakanishi H, Ohswa M, Naka N, Uchida A, Ochi T, Aosaza K. Immunohistochemical detection of bcl-2 and p53 proteins and apoptosis in soft tissue sarcoma: their correlations with prognosis. Oncology 1997; 54: 238-44.
31. Nickoloff BJ. The human progenitor cell antigen (CD34) is located on endothelial cells, dermal dendritic cells, and perifollicular cells in formalin-fixed normal skin, and on proliferating endothelial cells and stromal spindle shaped cells in Kaposi's sarcoma. Arch Derm 1991; 127:523-9.
32. Nufiez G, London L, Hockenbery D, Alexander M, Mc Kearn J, Korsmeyer SJ. Deregulated bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines. J Immunol 1990;144:3602-18.
33. Pezella F, Gatter KC, Mason DY et al. Bcl-2 protein expression in follicular lymphomas in absence of 14;18 translocation. Lancet 1990; 336:1510-1.
34. Pezella F, Tse AGD, Cordell JL, Pulford KAF, Gatter KC, Mason DY. Expression of the bcl-2oncogene protein is not specific for the 14;18 chromosomal translocation. Am J Pathol 1990;137:225-32.
35. Pezella F, Turley H, Kuzu I, et al. Bcl-2 protein in non-small cell lung carcinoma. N Eng J Med 1993; 329: 690-4.
36. Renshaw AA, Pinkus GS, Corson JM. CD34 and AE1/AE3. Diagnostic discriminants in the distinction of solitary fibrous tumor of the pleura from sarcomatoid mesothelioma. Appl Immunohistochem 1994; 2:94-102.
37. Sankey EA, More L, Dhillon AP. QBEnd/10: A new immunostain for the routine diagnosis of Kaposi's sarcoma. J Pathol 1990; 161:267-71.
38. Schlingemann RO, Rietveld FJ, de Waal RM et al. Leukocyte antigen CD34 is expressed by a subset of cultured endothelial cells and on endothelial abluminal microprocesses in the tumor stroma. Lab Invest 1990; 62:690-6.
39. Suster S. Gastrointestinal stromal tumors. Sem Diagn Pathol 1996; 13:297-313.
40. Suster S, Fisher C. Immunoreactivity for the human progenitor cell antigen (CD34) in lipomatous tumors. Am J Surg Pathol 1997; 21:195-200.
41. Suster S, Fisher C, Moran CA. Dendritic fibromyxolipoma. Clinicopathologic study of a distinctive benign soft tissue lesion that may be mistaken for a sarcoma. Ann Diagn Pathol 1998;2:111-20.
42. Suster S, Nascimento AG, Miettinen M, Sickel JZ, Moran CA. Solitary fibrous tumors of soft tissue. A clinicopathologic and immunohistochemical study of 12 cases. Am J Surg Pathol 1995;19:1257-66.
43. Suster S, Wong T-Y. On the discriminatory value of anti-HPCA-1 (CD34) in the differential diagnosis of benign and malignant cutaneous vascular proliferations. Am J Dermatopathol 1994;16:355-63.
44. Tsujimoto Y, Croce CM. Analysis of the structure, transcripts and protein products of bcl-2, the gene involved in human follicular lymphoma. Proc Natl Acad Sci, USA 1986; 83: 5214-18.
45. Tsujimoto Y, Ikegaki N, Croce CM. Characterization of the protein product of bcl-2, the gene involved in human follicular lymphoma. Oncogene 1987;2:3-7.
46. Van de Rijn M, Lombard CM, Rouse RV. Expression of CD34 by solitary fibrous tumors of the pleura, mediastinum and lung. Am J Surg Pathol 1994; 18:814-20.
47. Van de Rijn M, Rouse RV. CD34. A review. Appl Immunohistochem 1994; 2:71-80.
48. Weiss SW, Nickoloff BJ. CD34 is expressed by a distinct population of peripheral nerve, nerve sheath tumors, and related lesions. Am J Surg Pathol 1993; 17:1039-45.
49. Westra WH, Gerald WL, Rosai J. Solitary fibrous tumor. Consistent CD34 immunoreactivity and occurrence in the orbit. Am J Surg Pathol 1994; 18:992-8.