Efficacy of novel calpain inhibitors in preventing renal cell death

Journal of Pharmacology and Experimental Therapeutics

Volumn 294, Issue 3, 2000, Pages 1083-1087

  Harriman, J F ^a   Waters Williams, S ^a   Chu, D L ^a   Powers, J C ^a   Schnellmann, R G ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMYCIN A1; CALPAIN; CALPASTATIN; DIPEPTIDE; TRIPEPTIDE;

ANIMAL TISSUE; ANOXIA; ARTICLE; CELL DEATH; CELL PROTECTION; CONTROLLED STUDY; DRUG EFFICACY; DRUG PENETRATION; DRUG POTENCY; DRUG SPECIFICITY; KIDNEY CELL; KIDNEY PROXIMAL TUBULE; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ANIMALS; ANTIMYCIN A; CALPAIN; CELL DEATH; CELL MEMBRANE PERMEABILITY; DIPEPTIDES; ENZYME INHIBITORS; FEMALE; ISOENZYMES; KIDNEY TUBULES, PROXIMAL; OLIGOPEPTIDES; RABBITS;

EID: 0033842469     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Postischemic administration of AK275, a calpain inhibitor, provides substantial protection against focal ischemic brain damage
2. Calpain as a novel target for treating acute neurodegenerative disorders
3. pH-dependent nonlysosomal proteolysis contributes to lethal anoxic injury of rat hepatocytes
4. Mechanistic studies on the inactivation of the proteasome by lactacystin
5. The role of cysteine proteases in hypoxia-induced rat renal proximal tubular injury
6. Modulation of hypoxia-induced calpain activity in rat renal proximal tubules
7. An interleukin-1β-converting enzyme-like protease is a common mediator of apoptosis in thymocytes
8. Novel peptidyl alpha-keto amide inhibitors of calpains and other cysteine proteases
9. Peptide alpha-keto ester, alpha-keto amide, and alpha-keto acid inhibitors of calpains and other cysteine proteases
10. Protein measurement with folin phenol reagent
11. A rapid β-NADH-linked fluorescence assay for lactate dehydrogenase in cellular death
12. Differences in enzymatic and mechanical isolated rabbit renal proximal tubules: Comparison in long-term incubation
13. Calpain: New perspectives in molecular diversity and physiological-pathological involvement
14. Comparative specificity and kinetic studies on porcine calpain I and caipain II with naturally occurring peptides and synthetic fluorogenic substrates
15. Calpains play a critical role in renal proximal tubule (RPT) cell death
16. Calpain II involvement in mitosis
17. Structure and physiological function of calpains
18. Calcium activated neutral protease-structure function relationship and functional implications
19. Modulation of cellular signals by calpain
20. An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective
21. Calpain inhibition: An overview of its therapeutic potential
22. Calpains mediate calcium and chloride influx during the late phase of cell injury
23. The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol
24. Proteinases in renal cell death
25. An ICE-like protease is a common mediator of apoptosis induced by diverse stimuli in human monocytic THP.1 cells