Targeted intracellular delivery of photosensitizers to enhance photodynamic efficiency

Immunology and Cell Biology

Volumn 78, Issue 4, 2000, Pages 452-464

  Rosenkranz, Andrey A ^a,b   Jans, David A ^c   Sobolev, Alexander S ^a,b  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

^b INSTITUTE OF GENE BIOLOGY   (Russian Federation)

^c Australian National University   (Australia)

Author keywords

Nuclear import; Nuclear localization sequence; Photodynamic therapy; Photosensitizer; Receptor mediated endocytosis; Targeted delivery

Indexed keywords

PHOTOSENSITIZING AGENT;

CANCER THERAPY; CELLULAR DISTRIBUTION; CONFERENCE PAPER; CYTOPLASM; ENDOCYTOSIS; HEPATOMA CELL; HUMAN; HUMAN CELL; PHOTODYNAMIC THERAPY; PHOTOSENSITIZATION; TUMOR CELL;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CELL NUCLEUS; CYTOPLASM; DRUG CARRIERS; DRUG DESIGN; HUMANS; MOLECULAR SEQUENCE DATA; NEOPLASMS; NUCLEAR LOCALIZATION SIGNALS; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS;

EID: 0033841523     PISSN: 08189641     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1711.2000.00925.x     Document Type: Conference Paper

References (140)

1. Efficacy of photodynamic therapy against doxorubicin-resistant murine tumors
2. Photodynamic therapy for recurrent nasopharyn-geal cancer
3. Critical importance of the triplet lifetime of the photosensitizer in photodynamic therapy of tumors
4. The photodegradation of porphyrins in cells can be used to estimate the lifetime of singlet oxygen
5. Diffusion distances of known iron complexes in model systems
6. Subcellular phototoxicity of 5-aminolaevulinic acid (ALA)
7. Damage to DNA by reactive oxygen and nitrogen species: Role in inflammatory disease and progression to cancer
8. Nuclear targeting of chlorin e6 enhances its photosensitizing activity
9. Adenovirus synergize with nuclear localisation signals to enhance nuclear delivery and photodynamic action of internalizible conjugates containing chlorin e6
10. Sensitivity of 9L gliosarcomas to photodynamic therapy
11. The distribution of the tumour photosensitizers Zn (II) -phthalocyanine and Sn (IV)-etiopurpurin among rabbit plasma proteins
12. Liposomal delivery of a photosensitizer, benzoporphyrin derivative monoacid ring A (bpd), to tumor tissue in a mouse tumor model
13. Serum albumin as a vehicle for zinc phthalocyanine: Photodynamic activities in solid tumour models
14. Nature of the tumor-localizing components of hematoporphyrin derivative
15. Cellular uptake of hydroxyethylvinyldeuteroporphyrin (hvd) and photoinactivation of cultivated human leukemia (reh6) cells
16. Photosensitizing potencies of the structural analogues of benzoporphyrin derivative in different biological test systems
17. Lysosomes and microtubules as targets for photochemotherapy of cancer
18. Photodynamic effects of protoporphyrin on the cellular level - An in vitro approach
19. 9-Acetoxy-2,7,12,17-tetrakis-(beta-methoxyethyl)-porphycene (ATMPn); a novel photosensitizer for photodynamic therapy Uptake kinetics and intracellular localization
20. In vitro photodynamic effects of lysyl chlorin p6: Cell survival, localization and ultrastructural changes
21. Laser line-scanning confocal fluorescence imaging of the photodynamic action of aluminum and zinc phthalocyanines in V79-4 Chinese hamster fibroblasts
22. Photobiological properties of hematoporphyrin diesters: Evaluation for possible application in photochemotherapy of cancer
23. Apoptosis or necrosis following Photofrin photosensitization: Influence of the incubation protocol
24. Cellular uptake and relative efficiency in cell inactivation by photoactivated sulfonated meso-tetraphenylporphines
25. Role of calcium in photodynamically induced cell damage of human fibroblasts
26. Subcellular localization, redistribution and photobleaching of sulfonated aluminum phthalocyanines in a human melanoma cell line
27. Subcellular distribution, photocytotoxicity of aluminium phthalocyanines and haematoporphyrin derivative in cultured human meningioma cells
28. A comparative study of the cellular uptake and photodynamic efficacy of three novel zinc phthalocyanines of differing charge
29. Subcellular localization of meta-tetra (hydroxyphenyl) chlorin in human tumor cells subjected to photodynamic treatment
30. Light induced relocalization of sulfonated mesotetraphenylporphines in nhik 3025 cells and effects of dose fractionation
31. Subcellular localization of sulfonated tetraphenyl porphines in colon carcinoma cells by spectrally resolved imaging
32. Localization and efficacy analysis of the phototherapeutic lutetium texaphyrin (PCI-0123) in the murine EMT6 sarcoma model
33. Photosensitized destruction of human bladder carcinoma cells treated with chlorin e6-conjugated microspheres
34. Photosensitization with derivatives of chlorin p6
35. Photosensitization of human skin cell lines by ATMPn (9-acetoxy-2,7,12,17-tetrakis-(beta-methoxyethyl)-porphycene) in vitro Mechanism of action
36. Effects of the subcellular redistribution of two Nile blue derivatives on photodynamic oxygen consumption
37. Enhancement of Nile blue derivative-induced photocytotoxicity by nigericin and low cytoplasmic pH
38. Subcellular localization patterns and their relationship to photodynamic activity of pyropheophorbide-a derivatives
39. Photodynamic effects of sulfonated aluminum chlorophthalocyanine in human urinary bladder carcinoma cells in vitro
40. Selective tumor uptake of a boronated porphyrin in an animal model of cerebral glioma
41. Selective photosensitization of mitochondria by the lipophilic cationic porphyrin POR10
42. Selective photosensitization of mitochondria in HeLa cells by cationic Zn (II) phthalocyanines with lipophilic side-chains
43. Fourier transform multipixel spectroscopy and spectral imaging of protoporphyrin in single melanoma cells
44. Modification of the photodynamic action of delta-aminolaevulinic acid (ala) on rat pancreatoma cells by mitochondrial benzodiazepine receptor ligands
45. The subcellular localization of Zn (II) phthalocyanines and their redistribution on exposure to light
46. Intracellular fluorescence behaviour of meso-tetra (4-sulphonatophenyl) porphyrin during photodynamic treatment at various growth phases of cultured cells
47. Distribution of tetrapyrrole photosensitizers among human plasma proteins
48. Photodynamic therapy
49. Effect of endocytosis inhibitors on alveolar clearance of albumin, immunoglobulin γ, and SP-A in rabbits
50. Ultrastructural study of transcellular transport of native and cationized albumin in cultured goat brain microvascular endothelium
51. Accelerated endocytosis and incomplete catabolism of radical-damaged protein
52. Tumor localization and photosensitization by sulfonated derivatives of tetraphenylporphine
53. Receptor-mediated uptake of low-density lipoprotein by B16 melanoma cells in vitro and in vivo in mice
54. Selective occlusion of ocular neovascularization by photodynamic therapy
55. Distribution of endogenous and injected porphyrins at the subcellular level in rat hepatocytes and in ascites hepatoma
56. Correlation of subcellular and intratumoral photosensitizer localization with ultrastructural features after photodynamic therapy
57. Localization of potent photosensitizers in human tumor lox by means of laser scanning microscopy
58. Location of p-ii and alpcs4 in human tumor lox in vitro and in vivo by means of computer-enhanced video fluorescence microscopy
59. Dynamic fluorescence changes during photodynamic therapy in vivo and in vitro of hydrophilic Al (III) phthalocyanine tetrasulphonate and lipophilic Zn (II) phthalocyanine administered in liposomes
60. Structure and biodistribution relationships of photodynamic sensitizers
61. Effect of photosensitizer delivery system and irradiation parameters on the efficiency of photodynamic therapy of B 16 pigmented melanoma in mice
62. Role of delivery vehicles for photosensitizers in the photodynamic therapy of tumours
63. Binding of etiopurpurin and tin-coordinated etiopurpurin to human plasma I proteins. Delivery in Cremophore el and dimethyl sulfoxide (paper II)
64. Photodynamic therapy of tumours with hexadecafluoro zinc phthalocynine formulated in PEG-coated poly (lactic acid) nanoparticles
65. Photoimmunotherapy and biodistribution with an OC125-chlorin immunoconjugate in an in vivo murine ovarian cancer model
66. Photoimmuno of human uveal melanoma cells
67. Dynamics of photoinduced cell plasma membrane injury
68. Insulin-mediated intracellular targeting enhances the photodynamic activity of chlorin e6
69. Effect of charge on the interaction of site-specific photoimmunoconjugates with human cells ovarian cancer
70. HPMA copolymer-anticancer drug-OV-TL16 antibody conjugates. II. Processing in epithelial ovarian carcinoma cells in vitro
71. Development of meta-tetrahydroxyphenylchlorin-monoclonal antibody conjugates for photoimmunotherapy
72. A comparison of direct and liposomal antibody conjugates of sulfonated aluminum phthalocyanines for selective photoimmunotherapy of human bladder carcinoma
73. In-vitro photocytotoxicity of lysosomotropic immunoliposomes containing pheophorbide a with human bladder carcinoma cells
74. Evidence for a major role of plasma lipoproteins as hematoporphyrin carriers in vivo
75. Assimilation of LDL by experimental tumours in mice
76. Low density lipoprotein receptor-binding activity in human tissues: Quantitative importance of hepatic receptors and evidence for regulation of their expression in vivo
77. Uptake of low-density lipoprotein by malignant cells - Possible therapeutic applications
78. Evidence for low-density lipoprotein receptor-mediated uptake of benzoporphyrin derivative
79. Identification and partial characterization of an unusual distribution of the photosensitizer meta-tetrahydroxyphenyl chlorin (temoporfin) in human plasma
80. Photodynamic effects of a concanavalin A-chlorin e6 conjugate on human fibroblasts
81. The use of internalizable derivatives of chlorin e6 for increasing its photosensitizing activity
82. Internalizable insulin-BSA-chlorin e6 conjugate is a more effective photosensitizer than chlorin e6 alone
83. Receptor-mediated endocytosis and nuclear transport of a transfecting DNA construct
84. Nuclear targeting by growth factors, cytokines and their receptors: A role in signaling?
85. Intralobular heterogeneity of carbon tetrachloride-induced oxidative stress in perfused rat liver visualized by digital imaging fluorescence microscopy
86. Photosensitizer targeting in photodynamic therapy. I. Conjugates of haematoporphyrin with albumin and transferrin
87. Photocytotoxic action of EGF-PVA-Sn (IV) chlorin e6 and EGF-dextran-Sn (IV) chlorin e6 internalizable conjugates on A431 cells
88. Selective targeting, photodynamic destruction of intimal hyperplasia by scavenger-receptor mediated protein-chlorin e6 conjugates
89. Receptor-mediated targeting of phthalocyanines to macrophages via covalent coupling to native or maleylated bovine serum albumin
90. Regulation of protein transport to the nucleus - The central role of phosphorylation
91. Nucleocytoplasmic transport: Signals, mechanisms and regulation
92. The nuclear pore complex: From molecular architecture to functional dynamics
93. A monoclonal antibody against the nuclear pore complex inhibits nucleocytoplasmic exchange of protein and RNA in vivo
94. A giant nucleopore protein that binds Ran/TC4
95. Sequence requirements for nuclear location of simian virus 40 large T-antigen
96. Construction and characterization of an SV40 mutant defective in nuclear transport of T-antigen
97. Nuclear import can be separated into distinct steps in vitro: Nuclear pore binding and translocation
98. Nuclear protein migration involves two steps: Rapid binding at the nuclear envelope followed by slower translocation through nuclear pores
99. Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: Identification of a class of bipartite nuclear targeting sequence
100. Homeodomain of yeast repressor alpha 2 contains a nuclear localization signal
101. Comparative mutagenesis of nuclear localization signals reveals the importance of neutral and acidic amino acids
102. Kinetic characterization of the human retinoblastoma protein bipartite nuclear localization sequence in vivo and in vitro: A comparison with the SV40 large T-antigen NLS
103. Plant importin α binds nuclear localization sequences with high affinity and mediates nuclear import independent of importin β
104. 312) enhances Dorsal nuclear import through facilitating nuclear localization sequence/importin interaction
105. Nuclear import in permeabilized protoplasts from higher plants has unique features
106. Importin alpha from Arabidopsis thaliana is a nuclear import receptor that recognizes three classes of import signals
107. Efficiency of importin α/β-mediated NLS recognition and nuclear import: Differential role of NTF2
108. Association of the T-cell protein tyrosine phosphatase with nuclear import factor p97
109. Interactions between HIV Rev and nuclear import and export factors: The Rev nuclear localisation signal mediates specific binding to human importinbeta
110. Mutual exclusivity of DNA binding and nuclear localization signal recognition by the yeast transcription factor GAL4: Implications for non-viral DNA delivery
111. Importin β recognizes parathyroid hormone-related protein (PTHrP) with high affinity and mediates its nuclear import in the absence of importin α
112. The arginine-rich domains present in human immunodeficiency virus type 1 Tat and Rev function as direct importin β-dependent nuclear localization signals
113. Nuclear targeting signal recognition: A key control point of nuclear transport
114. Importin β, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells
115. Yrb4p, a yeast Ran-GTP-binding protein involved in import of r bosomal protein L25 into the nucleus
116. A nuclear export signal in hnRNP Al: A signal-mediated, temperature-dependent nuclear protein export pathway
117. Signals mediating nuclear targeting and their regulation: Application in drug delivery
118. The HIV-1 Fat nuclear localization sequence confers novel nuclear import properties
119. Nuclear targeting with loligomers dramatically increases the photodynamic activity of chlorin e6
120. Partial characterization of mechanism of insulin accumulation in H35 hepatoma cell nuclei
121. Stepwise dismantling of adenovirus 2 during entry into cells
122. Adenovirus-induced release of epidermal growth factor, pseudomonas toxin into the cytosol of kb cells during receptor-mediated endocytosis
123. Adenovirus-dependent release of chorine from plasma membrane vesicles at an acidic pH is mediated by the penton base protein
124. Receptor-mediated transfection of murine and ovine mammary glands in vivo
125. Homologous and heterologous regulation of alpha-melanocyte-stimulating hormone receptors in human and mouse melanoma cell lines
126. Melan-receptors: Membrane markers of human otropic peptide melanoma cells
127. The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling
128. Comparison of (111)In-labeled somatostatin analogues for tumor scintigraphy and radionuclide therapy
129. Pre-clinical comparison of [DTPA0] octreotide, [DTPA0,Tyr3] octreotide and [DOTA0,Tyr3] octreotide as careers for somatostatin receptor-targeted scintigraphy radionuclide therapy
130. The association of polypeptide hormones and growth factors with the nuclei of target cells
131. Nuclear signaling pathways for polypeptide ligands and their membrane receptors?
132. The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems
133. Influenza virus hemagglutinin ha-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-Dna complexes: Toward a synthetic virus-like gene-transfer vehicle
134. Specific gene transfer mediated by lactosylated poly-1-lysine into hepatoma cells
135. pH-dependent fusion of phosphatidylcholine small vesicles. Induction by a synthetic amphipathic peptide
136. Enhanced in vitro tumor cell retention and internalization of antibody derivatized with synthetic peptides
137. Isolation and nucleotide sequence of the hmp gene that encodes a haemoglobin-like protein in Escherichia coli K-12
138. PEG-coated poly α (lactic acid) nanoparticles for the delivery of hexadecafluoro zinc phthalocyanine to emt-6 mouse mammary tumours
139. Tolerogenic capacity of poly(ethylene glycol) (PEG)-modified ovalbumins in relation to their immunoreactivity towards anti-ovalbumin antibody