Evidence that dark-phase hyperphagia induced by neurotoxin 6- hydroxydolpamine may be due to decreased leptin and increased neuropeptide Y signaling

Physiology and Behavior

Volumn 63, Issue 5, 1998, Pages 829-835

  Kalra, P S ^a   Dube, M G ^a   Xu, B ^a   Farmerie, W G ^a   Kalra, S P ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Hyperphagia; Leptin; Neuropeptide Y; Obesity

Indexed keywords

LEPTIN; NEUROPEPTIDE; OXIDOPAMINE; SIGNAL PEPTIDE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; FOOD INTAKE; HORMONE BLOOD LEVEL; HYPERPHAGIA; HYPOTHALAMUS; LIGHT DARK CYCLE; MALE; NEUROSECRETION; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT;

EID: 0032030284     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-9384(97)00545-3     Document Type: Article

References (59)

1. Ahlskog J. E., Hoebel B. G. Overeating and obesity from damage to a noradrenergic system in the brain. Science. 182:1973;166-169.
2. Ahlskog J. E., Randall P. K., Hoebel B. G. Hypothalamic hyperphagia Dissociation from hyperphagia following destruction of noradrenergic neurons . Science. 190:1975;399-401.
3. Avrith D., Mogenson G. J. Reversible hyperphagia and obesity following intracerebral microinjections of colchicine into the ventromedial hypothalamus of the rat. Brain Res. 153:1978;99-107.
4. Bray G. A. Mechanism for development of genetic, hypothalamic and dietary obesity. Bray G. H., Ryan D. H. Molecular and genetic aspects of obesity. Vol. 5. 1996;2-66 LSU Press, Baton Rouge.
5. Bray G. A., Ryan D. H. Molecular and genetic aspects of obesity. Vol. 5. 1996;LSU Press, Baton Rouge.
6. Campfield L. A., Smith F. J., Guisez Y., Devos R., Burn P. Recombinant mouse OB protein Evidence for a peripheral signal linking adiposity and central neural networks . Science. 269:1995;546-549.
7. Caro J. F., Sinha M. K., Kolaczynski J. W., Zhang P. L., Considine R. V. Leptin The tale of an obesity gene . Diabetes. 45:1996;1455-1462.
8. Chen H., Charlat O., Tartaglia L. A., Woolf E. A., Weng X., Ellis S. J., Lakey N. D., Culpepper J., Moore K. J., Breitbart R. E., Duyk G. M., Tepper R. I., Morgenstern J. P. Evidence that the diabetes gene encodes the leptin receptor Identification of a mutation in the leptin receptor gene in db/db mice . Cell. 84:1996;491-495.
9. Clark J. T., Kalra P. S., Crowley W. R., Kalra S. P. Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology. 115:1984;427-429.
10. Daniels A. J., Matthews J. E., Slepetis R. J., Jansen M., Viveros O. H., Tadepalli A., Harrington W., Heyer D., Landavazo A., Leban J. J. High-affinity neuropeptide Y receptor antagonists. Proc. Natl. Acad. Sci. USA. 92:1995;9067-9071.
11. Dryden S., Pickavance L., Frankish H. M., Williams G. Increased neuropeptide Y secretion in the hypothalamic paraventricular nucleus of obese (fa/fa) Zucker rats. Brain Res. 690:1995;185-188.
12. Dube M. G., Sahu A., Kalra P. S., Kalra S. P. Neuropeptide Y release is elevated from the microdissected paraventricular nucleus of food-deprived rats An in vitro study . Endocrinology. 131:1992;684-688.
13. Dube, M. G.; Sahu, A.; Phelps, C. P.; Kalra, P. S.; Kalra, S. P. Neuropeptide Y concentrations decreased in the paraventricular nucleus (PVN) of rats exhibiting excessive body weight gain produced by ventromedial hypothalamic (VMH) lesions (abstr 296.6). 21st Annu. Meeting Soc. Neurosci. 18:937; 1991.
14. Dube M. G., Xu B., Crowley W. R., Kalra P. S., Kalra S. P. Evidence that neuropeptide Y is a physiological signal for normal food intake. Brain Res. 646:1994;341-344.
15. Dube, M. G.; Xu, B.; Kalra, S. P.; Kalra, P. S. Neurotoxin-induced transient hyperphagia is negatively correlated with hypothalamic neuropeptide Y (abstr 184.15). 26th Annu. Meeting Soc. Neurosci. 22:466; 1996.
16. Everitt B. J., Hokfelt T. The coexistence of neuropeptide Y with other peptides and amines in the central nervous system. Mutt V., Hokfelt T., Lundberg J. D. Neuropeptide Y. 1989;61-72 Raven Press, New York.
17. Funahashi T., Shimomura I., Hiraoka H., Arai T., Takahashi M., Nakamura T., Nozaki S., Yamashita S., Takemura K., Tokunaga K. Enhanced expression of rat obese (ob) gene in adipose tissues of ventromedial hypothalamus (VMH)-lesioned rats. Biochem. Biophys. Res. Commun. 211:1995;469-475.
18. Gerald C., Walker M. W., Criscione L., Gustafson E. L., Batzl Hartmann C., Smith K. E., Vaysse P., Durkin M. M., Laz T. M., Linemeyer D. L., Schaffhauser A. O., Whitebread S., Hofbauer K. G., Taber R. I., Branchek T. A., Weinshank R. L. A receptor subtype involved in neuropeptide-Y-induced food intake. Nature. 382:1996;168-171.
19. Gillard E. R., Dang D. Q., Stanley B. G. Evidence that neuropeptide Y and dopamine in the perfornical hypothalamus interact antagonistically in the control of food intake. Brain Res. 628:1993;128-136.
20. Grundemar L., Bloom S. R. Neuropeptide Y and drug development. 1997;Academic Press, San Diego.
21. Hernandez L., Hoebel B. G. Overeating after midbrain 6-hydroxydopamine prevention by central injection of selective catecholamine reuptake blockers . Brain Res. 245:1982;333-343.
22. Kalra, P. S.; Dube, M. G.; Xu, B.; Farmerie, W. G.; Kalra, S. P. Ventromedial nucleus (VMN) - A putative site of negative feedback action of leptin on appetite: Implication for leptin resistance. (abstr 337.6) 27th Annu. Meeting Soc. Neurosci. 23:851; 1997.
23. Kalra P. S., Dube M. G., Xu B., Farmerie M. G., Kalra S. P. Neuropeptide Y (NPY) Y1 receptor mRNA is upregulated in association with transient hyperphagia and body weight gain Evidence for a hypothalamic site for concurrent devleopment of leptin resistance . J. Neuroendocrinol. 10:1998;41-47.
24. Kalra P. S., Dube M. G., Xu B., Kalra S. P. Increased receptor sensitivity to neuropeptide Y in the hypothalamus may underlie transient hyperphagia and body weight gain. Regul. Pept. 72:1997;121-130.
25. Kalra S. P. Appetite and body weight regulation Is it all in the brain? Neuron. 19:1997;227-230.
26. Kalra S. P., Dube M. G., Fournier A., Kalra P. S. Structure-function analysis of stimulation of food intake by neuropeptide Y Effects of receptor agonists . Physiol. Behav. 50:1991;5-9.
27. Kalra S. P., Dube M. G., Sahu A., Phelps C. P., Kalra P. S. Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. Proc. Natl. Acad. Sci. USA. 88:1991;10931-10935.
28. Kalra, S. P.; Dube, M. G.; Xu, B.; Farmerie, W. G.; Kalra, P. S. Transient interruption of neural signaling by neurotoxin injection into the ventromedial hypothalmaus (VMH) induced temporary hyperphagia and upregualtes NPY Y1 receptor gene expression (abstr 528.4). 27th Annu. Meeting Soc. Neurosci. 23:1344; 1997.
29. Kalra S. P., Kalra P. S. Is neuropeptide Y a naturally-occurring appetite transducer? Curr. Opin. Endocrinol. Diab. 3:1996;157-163.
30. Kalra S. P., Sahu A., Dube M. G., Bonavera J. J., Kalra P. S. Neuropeptide Y and its neural connections in the etiology of obesity and associated neuroendocrine and behavioral disorders. Bray G. H., Ryan D. H. Molecular and genetic aspects of obesity. Vol. 5. 1996;219-232 LSU Press, Baton Rouge.
31. Kanatani A., Ishihara A., Asahi S., Tanaka T., Ozaki S., Ihara M. Potent neuropeptide Y Y1 receptor antagonist, 1229U91 Blockade of neuropeptide Y-induced and physiological food intake . Endocrinology. 137:1996;3177-3182.
32. King B. M., Daigrepont P. M., Michel R. E., Zansler C. A., Ahmed J. I., Walker A., Frohman L. A. Hypothalamic obesity Comparison of radio-frequency and electrolytic lesions in male and female rats . Brain Res. Bull. 17:1986;408-418.
33. Klein D. C., Moore R. Y., Reppert S. M. Suprachiasmatic nucleus The mind's clock . 1991;Oxford University Press, New York.
34. Larhammar D. Extraordinary structural diversity of NPY-family receptors. Grundemar L., Bloom S. R. Neuropeptide Y and drug development. 1997;87-105 Academic Press, San Diego.
35. Larhammar D., Blomquist A. G., Yee F., Jazin E., Yoo H., Wahlstedt C. Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type. J. Biol. Chem. 267:1992;10935-10938.
36. Lee G. H., Proenca R., Montez J. M., Carroll K. M., Darvishzadeh J. G., Lee J. I., Friedman J. M. Abnormal splicing of the leptin receptor in diabetic mice. Nature. 379:1996;632-635.
37. Mercer J. G., Hoggard N., Williams L. M., Lawrence C. B., Hannah L. T., Morgan P. J., Trayhurn P. Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus. J. Neuroendocrinol. 8:1996;733-735.
38. Mercer J. G., Hoggard N., Williams L. M., Lawrence C. B., Hannah L. T., Trayhurn P. Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett. 387:1996;113-116.
39. Morley J. E. Neuropeptide regulation of appetite and weight. Endocrin. Rev. 8:1987;256-287.
40. Ogawa Y., Masuzaki H., Isse N., Mori K., Shigemoto M., Satoh N., Tamura N., Hosoda K., Yoshimasa Y., Jingami H., Kawada T., Nakao K. Molecular cloning of rat obese cDNA and augmented gene expression in genetically obese Zucker fatty (fa/fa) rats. J. Clin. Invest. 96:1995;1647-1652.
41. O'Shea D., Morgan D. G., Meeran K., Edwards C. M., Turton M. D., Choi S. J., Heath M. M., Gunn I., Taylor G. M., Howard J. K., Bloom C. I., Small C. J., Haddo O., Ma J. J., Callinan W., Smith D. M., Ghatei M. A., Bloom S. R. Neuropeptide Y induced feeding in the rat is mediated by a novel receptor. Endocrinology. 138:1997;196-202.
42. Paxinos G., Watson C. The rat brain in stereotaxic coordinates. 1986;Academic Press, San Diego.
43. Pelleymounter M. A., Cullen M. J., Baker M. B., Hecht R., Winters D., Boone T., Collins F. Effects of the obese gene product on body weight regulation in ob/ob mice [see comments]. Science. 269:1995;540-543.
44. Sahu A., Kalra S. P., Crowley W. R., Kalra P. S. Evidence that NPY-containing neurons in the brainstem project into selected hypothalamic nuclei Implication in feeding behavior . Brain Res. 457:1988;376-378.
45. Sahu A., Sninsky C. A., Phelps C. P., Dube M. G., Kalra P. S., Kalra S. P. Neuropeptide Y release from the paraventricular nucleus increases in association with hyperphagia in streptozotocin-induced diabetic rats. Endocrinology. 131:1992;2979-2985.
46. Saladin R., De Vos P., Guerre Millo M., Leturque A., Girard J., Staels B., Auwerx J. Transient increase in obese gene expression after food intake or insulin administration. Nature. 377:1995;527-529.
47. Sanacora G., Kershaw M., Finkelstein J. A., White J. D. Increased hypothalamic content of preproneuropeptide Y messenger ribonucleic acid in genetically obese Zucker rats and its regulation by food deprivation. Endocrinology. 127:1990;730-737.
48. Satoh N., Ogawa Y., Katsuura G., Hyase M., Tsuiji T., Iwagawa K., Yoshimasa Y., Nishi S., Hosoda K., Nakao K. The arcuate nucleus as a primary target of satiety effect of leptin in rats. Neurosci. Lett. 225:1997;149-152.
49. Satoh N., Ogawa Y., Katsuura G., Tsuji T., Masuzaki H., Hiraoka J., Okazaki T., Tamaki M., Hayase M., Yoshimasa Y., Nishi S., Hosoda K., Nakao K. Pathophysiological significance of the obese gene product, leptin, in ventromedial hypothalamus (VMH)-lesioned rats Evidence for loss of its satiety effect in VMH-lesioned rats . Endocrinology. 138:1997;947-954.
50. Schwartz M. W., Seeley R. J., Campfield L. A., Burn P., Baskin D. G. Identification of targets of leptin action in rat hypothalamus. J. Clin. Invest. 98:1996;1101-1106.
51. Sclafani A., Kirchgessner A. The role of the medial hypothalamlus in the control of food intake. An update. Ritter R. C., Ritter S., Barnes C. D. Feeding behavior Neural and humoral control . 1986;27-66 Academic Press, New York.
52. Spiegelman B. M., Flier J. S. Adipogenesis and obesity Rounding out the big picture . Cell. 87:1996;377-389.
53. Stanley B. G., Chin A. S., Leibowitz S. F. Feeding and drinking elicited by central injection of neuropeptide Y Evidence for a hypothalamic site(s) of action . Brain Res. Bull. 14:1985;521-524.
54. Stephens T. W., Basinski M., Bristow P. K., Bue Valleskey J. M., Burgett S. G., Craft L., Hale J., Hoffmann J., Hsiung H. M., Kriauciunas A. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature. 377:1995;530-532.
55. Tartaglia L. A., Dembski M., Weng X., Deng N., Culpepper J., Devos R., Richards G. J., Campfield L. A., Clark F. T., Deeds J. Identification and expression cloning of a leptin receptor, OB-R. Cell. 83:1995;1263-1271.
56. Weinberg D. H., Sirinathsinghji D. J., Tan C. P., Shiao L. L., Morin N., Rigby M. R., Heavens R. H., Rapoport D. R., Bayne M. L., Cascieri M. A., Strader C. D., Linemeyer D. L., MacNeil D. J. Cloning and expression of a novel neuropeptide Y receptor. J. Biol. Chem. 271:1996;16435-16438.
57. White J. D., Olchovsky D., Kershaw M., Berelowitz M. Increased hypothalamic content of preproneuropeptide-Y messenger ribonucleic acid in streptozotocin-diabetic rats. Endocrinology. 126:1990;765-772.
58. Xu B., Dube M. G., Kalra P. S., Farmerie W. G., Kaihara A., Moldawer L. L., Martin D., Kalra S. P. Anorectic effects of the cytokine, ciliary neurotropic factor (CNTF) are mediated by hypothalamic neuropeptide Y (NPY) Comparison with leptin . Endocrinology. 139:1998;466-473.
59. Xu, B.; Kalra, P. S.; Kalra, S. P. Food restriction upregulated hypothalamic NPY gene expression: Loss of daily rhythm (abstr 663.5). 26th Annual Meeting Soc. Neurosci. 22:345; 1996.