The interaction between Ran and NTF2 is required for cell cycle progression

Molecular Biology of the Cell

Volumn 11, Issue 8, 2000, Pages 2617-2629

  Quimby, B B ^a   Wilson, C A ^a   Corbett, A H ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATE; NUCLEAR PROTEIN; NUCLEAR TRANSPORT FACTOR 2; RAN PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL COMPARTMENTALIZATION; CELL CYCLE; CELL CYCLE G2 PHASE; CELLULAR DISTRIBUTION; INTERPHASE; INTRACELLULAR TRANSPORT; MACROMOLECULE; MITOSIS SPINDLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SACCHAROMYCES CEREVISIAE; TEMPERATURE DEPENDENCE;

EID: 0033840551     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.11.8.2617     Document Type: Article

References (44)

1. Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1
2. The 1.6Å resolution crystal structure of nuclear transport factor 2 (NTF2)
3. Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation
4. Green fluorescent protein as a marker for gene expression
5. Nuclear protein import is decreased by engineered mutants of nuclear transport factor 2 (NTF2) that do not bind GDP-Ran
6. Separate binding sites on nuclear transport factor 2 (NTF2) for GDP-Ran and the phenylalanine-rich repeat regions on nucleoporins p62 and Nsp1p
7. The NTF2 gene encodes an essential, highly conserved protein that functions in nuclear transport in vivo
8. Nucleocytoplasmic transport of macromolecules
9. RCC1 in the cell cycle: The regulator of chromosome condensation takes on new roles
10. CLB5: A novel B cyclin from budding yeast with a role in S phase
11. The spindle checkpoint: Two transitions, two pathways
12. The spindle checkpoint
13. Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption
14. The yeast RNA1 gene product necessary for RNA processing is located in the cytosol and apparently excluded from the nucleus
15. S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function
16. Kinetics of spindle pole body separation in budding yeast
17. The Ran GTPase regulates mitotic spindle assembly
18. Crystallization and preliminary X-ray diffraction analysis of nuclear transport factor 2
19. Engineered mutants in the switch II loop of Ran define the contribution made by key residues to the interaction with nuclear transport factor 2 (NTF2) and the role of this interaction in nuclear protein import
20. Feedback control of mitosis in budding yeast
21. The yeast nuclear import receptor is required for mitosis
22. Nucleocytoplasmic transport: The soluble phase
23. Purification of a Ran-interacting protein that is required for protein import into the nucleus
24. When overexpressed, a novel centrosomal protein, RanBPM, causes ectopic microtubule nucleation similar to gamma-tubulin
25. Self-organization of microtubule asters induced in Xenopus egg extracts by GTP-bound Ran
26. Isolation and characterization of the active cDNA of the human cell cycle gene (RCC1) involved in the regulation of onset of chromosome condensation
27. The RCC1 protein, a regulator for the onset of chromosome condensation locates in the nucleus and binds to DNA
28. High levels of the GTPase Ran/TC4 relieve the requirement for nuclear protein transport factor 2
29. Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62
30. NTF2 mediates nuclear import of Ran
31. The spindle assembly checkpoint
32. Tubulin dynamics in cultured mammalian cells
33. The Ran decathlon: Multiple roles of Ran
34. In vivo nuclear transport kinetics in Saccharomyces cerevisiae: A role for heat shock protein 70 during targeting and translocation
35. Nuclear import of Ran is mediated by the transport factor NTF2
36. Monoclonal antibodies to NTF2 inhibit nuclear protein import by preventing nuclear translocation of the GTPase Ran
37. Structural basis for the molecular recognition between Nuclear Transport Factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran
38. The spindle assembly checkpoint in budding yeast
39. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedures and some application
40. Regulation of microtubule dynamics by cdc2 protein kinase in cell-free extracts of Xenopus eggs
41. Identification of a region in segment 1 of gelsolin critical for actin binding
42. Stimulation of microtubule aster formation and spindle assembly by the small GTPase Ran
43. Interaction between the small GTPase Ran/Gsp1p and Ntf2p is required for nuclear transport