Retrovirus-mediated transduction of primary ZAP-70-deficient human T cells results in the selective growth advantage of gene-corrected cells: Implications for gene therapy

Gene Therapy

Volumn 7, Issue 16, 2000, Pages 1392-1400

  Steinberg, M ^a   Swainson, L ^a   Schwarz, K ^b   Boyer, M ^a   Friedrich, W ^b   Yssel, H ^c   Taylor, N ^a   Noraz, N ^a  

^a INSTITUT DE GÉNÉTIQUE MOLÉCULAIRE DE MONTPELLIER   (France)

^b UNIVERSITY OF ULM   (Germany)

^c INSERM   (France)

Author keywords

Gene therapy; Retroviral transduction; TCR activation; ZAP 70 deficiency

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 2; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE ZAP 70; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; VIRUS VECTOR;

ARTICLE; CELL FUNCTION; CELL GROWTH; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; GENE THERAPY; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; RETROVIRUS; T LYMPHOCYTE;

HTLV; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN T-LYMPHOTROPIC VIRUS 1; RNA VIRUSES; UNIDENTIFIED RETROVIRUS;

EID: 0033839072     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301249     Document Type: Article

References (50)

1. ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR zeta chain
2. Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling
3. + thymic selection in humans lacking zap-70 kinase
4. ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency
5. Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase
6. Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases
7. A tyrosine-phosphorylated 70-kDa protein binds a photoaffinity analogue of ATP and associates with both the zeta chain and CD3 components of the activated T cell antigen receptor
8. The Syk family of protein tyrosine kinases in T-cell activation and development
9. Bone marrow transplantation in severe combined immunodeficiency: Potential and current limitations
10. European experience of bone marrow transplantation for severe combined immunodeficiency
11. The use of HLA-non-identical T-cell-depleted marrow transplants for correction of severe combined immunodeficiency disease
12. Reconstitution of T cell receptor signaling in ZAP-70-deficient cells by retroviral transduction of the ZAP-70 gene
13. Recruitment of SH2-containing protein tyrosine phosphatase SHP-1 to the interleukin 2 receptor; loss of SHP-1 expression in human T-lymphotropic virus type I-transformed T cells
14. Altered expression of tyrosine kinases of the Src and Syk families in human T-cell leukemia virus type 1-infected T-cell lines
15. Absence of transcription of lck (lymphocyte specific protein tyrosine kinase) message in IL-2-independent, HTLV-I-Transformed T cell lines
16. HTLV-1-associated diseases
17. Alternative TCR signaling in T cells derived from ZAP-70-deficient patients expressing high levels of Syk
18. Green fluorescent protein as a selectable marker of fibronectin- facilitated retroviral gene transfer in primary human T lymphocytes
19. Inhibition of T cell and promotion of natural killer cell development by the dominant negative helix-loop-helix factor Id3
20. Episomal vectors rapidly and stably produce high-titer recombinant retrovirus
21. Improved gene transfer into human lymphocytes using retroviruses with the gibbon ape leukemia virus envelope
22. High-efficiency retroviral-mediated gene transfer into human and nonhuman primate peripheral blood lymphocytes
23. Enhanced green fluorescent protein as an efficient reporter gene for retroviral transduction of human multipotent lymphoid precursors
24. T cell antigen receptor signal transduction pathways
25. Retrovirally marked CD34-enriched peripheral blood and bone marrow cells contribute to long-term engraftment after autologous transplantation
26. Gene-marking to trace origin of relapse after autologous bone marrow transplantation
27. T lymphocyte-directed gene therapy for ADASCID: Initial trial results after 4 years
28. Engraftment of gene-modified umbilical cord blood cells in neonates with adenosine deaminase deficiency
29. Improvement of gene transduction efficiency in T lymphocytes using retroviral vectors
30. Highly-efficient gene transfer with retroviral vectors into human T lymphocytes on fibronectin
31. High-efficiency gene transfer into normal and adenosine deaminase-deficient T lymphocytes is mediated by transduction on recombinant fibronectin fragments
32. Costimulation of transduced T lymphocytes via T cell receptor-CD3 complex and CD28 leads to increased transcription of integrated retrovirus
33. Retroviral-mediated gene correction for X-linked severe combined immunodeficiency
34. Gamma-c gene transfer into SCID X1 patients' B-cell lines restores normal high-affinity interleukin-2 receptor expression and function
35. Correction of interleukin-2 receptor function in X-SCID lymphoblastoid cells by retrovirally mediated transfer of the gamma-c gene
36. In vitro correction of JAK3-deficient severe combined immunodeficiency by retroviral-mediated gene transduction
37. Construction of retroviral vectors carrying human CD3 gamma cDNA and reconstitution of CD3 gamma expression and T cell receptor surface expression and function in a CD3 gamma-deficient mutant T cell line
38. Serum-free medium for generation and propagation of functional human cytotoxic and helper T cell clones
39. Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease
40. + cells in ADA-deficient SCID neonates
41. + T cells
42. Differential activation of the tyrosine kinases ZAP-70 and Syk after Fc gamma RI stimulation
43. Highly efficient gene transfer in naive human T cells with a murine leukemia virus-based vector
44. Gene therapy in peripheral blood lymphocytes and bone marrow for ADA-immunodeficient patients
45. Homozygous human TAP peptide transporter mutation in HLA class I deficiency (published erratum appears in Science 1994 266 1464)
46. MHC class I-deficient mice
47. Establishment of human T lymphocyte clones highly cytotoxic for an EBV-transformed B cell line in serum-free medium: Isolation of clones that differ in phenotype and specificity
48. Mutation of tyrosines 492/493 in the kinase domain of ZAP-70 affects multiple T-cell receptor signaling pathways
49. Construction and properties of retrovirus packaging cells based on gibbon ape leukemia virus
50. Production and characterization of functional domains of human fibronectin expressed in Escherichia coli