Electrophysiologic effects of the new I(Ks)-blocking agent chromanol 293b in the postinfarction canine heart: Preserved positive use-dependence and preferential prolongation of refractoriness in the infarct zone

Basic Research in Cardiology

Volumn 95, Issue 4, 2000, Pages 324-332

  Bauer, A ^a   Becker, R ^a   Freigang, K D ^a   Senges, J C ^a   Voss, F ^a   Kraft, P ^a   Kuebler, W ^a   Schoels, W ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

Antiarrhytmic agents; Heart; M cell; Mapping; Myocardial infarction

Indexed keywords

ANTIARRHYTHMIC AGENT; CHROMANOL 293B; POTASSIUM CHANNEL BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DOG; DRUG MECHANISM; EPICARDIUM MAPPING; HEART CONDUCTION; HEART INFARCTION; HEART MUSCLE REFRACTORY PERIOD; HEART PACING; NONHUMAN;

ANIMALS; CHROMANS; DOGS; HEART; MYOCARDIAL INFARCTION; POTASSIUM CHANNEL BLOCKERS; REFRACTORY PERIOD, ELECTROPHYSIOLOGICAL; SULFONAMIDES;

EID: 0033837338     PISSN: 03008428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003950070052     Document Type: Article

References (36)

1. The M cell: Its contribution to the ECG and to normal and abnormal electrical function of the heart
2. Effects of quinidine on repolarization in canine epicardium midmyocardium, and endocardium: II in vivo study
3. The controversial M cell
4. Rate- and site-dependent effects of propafenone, dofetilide, and the new I(Ks)-blocking agent chromanol 293b on individual muscle layers of the intact canine heart
5. Effects on repolarization of the chromanol 293b, a highly selective blocker of the slow component of the delayed rectifier K+ current (I(Ks)) in human and guinea pig ventricle
6. Inhibition of I(Ks) in guinea pig cardiac myocytes and guinea pig IsK channels by the chromanol 293b
7. QTU-prolongation and torsade de pointes induced by putative class III antiarrhythmic agents in the rabbit: Etiology and interventions
8. Electrophysiologic and hemodynamic effects of H 234/09 (Almokalant), quinidine, and (+) sotalol in the anesthetized dog
9. Mortality and morbidity in patients receiving encainide, flecainide, or placebo
10. The electrophysiological mechanism of ventricular arrhythmias in the long QT Syndrom
11. Differential effects of d-sotalol on normal and infarcted myocardium: An experimental study using epicardial mapping
12. The differential response of normal and ischaemic Purkinje fibers to clofilium, d-sotalol and bretylium
13. Reproducible and uniform cardiac ischemia: Effects of antiarrhythmic drugs
14. Antiarrhythmic drug action: Selective depression of hypoxic cardiac cells
15. Electrophysiological mechanism of ventricular arrhythmias resulting from myocardial ischemia and infarction
16. Rate-dependent prolongation of cardiac action potentials by a methanesulfonanilide class III antiarrhythmic agent: Specific block of rapidly activating delayed rectifier K current by dofetilide
17. Sodium channel blockade produces opposite electrophysiologic effects in canine ventricular epicardium and endocardium
18. Characteristics of the delayed rectifier current (I(Kr) and I(Ks)) of canine ventricular epicardial, midmyocardial, and endocardial myocytes. A weaker IKs contributes to the longer action potential of the M cell
19. Ionic bases for electrophysiological distinctions among epicardial, midmyocardial and endocardial myocytes from the free wall of the canine left ventricle
20. Comparison of bidisomid, flecainide and dofetilide on action potential duration in isolated canine atria: Effect of isoproterenol
21. Reentrant ventricular arrhythmias in the late myocardial infarction period. 9. Electrophysiologic-anatomic correlation of reentrant circuits
22. Effects of chronic treatment by amiodarone on transmural heterogeneity of canine ventricular repolarization in vivo: Interactions with acute sotalol
23. Reentrant and nonreentrant mechanisms contribute to arrhythmogenesis during early myocardial ischemia: Results using three-dimensional mapping
24. Two components of delayed rectifier K+ current
25. Delayed rectifier outward K+-current is composed of two currents in guinea-pig atrial cells
26. Sotalol exhibits reverse use-dependent action on monophasic action potentials in normal but not in infarcted canine ventricular myocardium
27. Circus movement atrial flutter in the canine sterile pericarditis model. Activation patterns during initiation termination, and sustained reentry in vivo
28. Differential effect of β-adrenergic stimulations on the frequency-dependent electrophysiologic actions of the new class III antiarrhythmics dofetilide, ambasilide, and chromanol 293b
29. A subpopulation of cells with unique electrophysiological properties in the deep subepicardium of the canine ventricle. The M cell
30. Effects of quinidine on repolarization in canine epicardium, midmyocardium, and endocardium: In vitro study
31. Electrophysiological and beta-receptor blocking effects of MJ 1999 on dog and rabbit cardiac tissue
32. Specific blockade of slowly activating Isk channels by chromanols-impact on the role of Isk channels in epithelia
33. Ionic mechanisms underlying the effects of sodium pentobarbital to diminish transmural dispersion of repolarization
34. Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction
35. Rapid and slow components of delayed rectifier current in human atrial myocytes