Roles of hydrophobicity, protein binding and the probenecid-sensitive transport system in the cerebrospinal fluid delivery of nucleoside analogues with anti-viral activity

Biological and Pharmaceutical Bulletin

Volumn 23, Issue 8, 2000, Pages 979-983

  Kawaguchi, Takeo ^a   Kusumi, Masaki ^a   Hasegawa, Tetsuya ^a   Nagata, Toshiyuki ^b   Saneyoshi, Mineo ^c   Nakano, Masahiro ^d   Hamada, Akinobu ^d  

^a JOSAI UNIVERSITY   (Japan)

^b Base Technology Center   (Japan)

^c TEIKYO UNIVERSITY OF SCIENCE   (Japan)

^d KUMAMOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

Anti viral activity; Cerebrospinal fluid; Hydrophobicity; Nucleoside analogue; Protein binding; Transport

Indexed keywords

ACICLOVIR; CYTARABINE; DIDANOSINE; FIACITABINE; NUCLEOSIDE ANALOG; PROBENECID; ZIDOVUDINE;

ANTIVIRAL ACTIVITY; ARTICLE; BLOOD CEREBROSPINAL FLUID BARRIER; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG PENETRATION; DRUG PROTEIN BINDING; DRUG TRANSPORT; HYDROPHOBICITY; MALE; NONHUMAN; PARTITION COEFFICIENT; RAT; STEADY STATE;

EID: 0033836149     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.23.979     Document Type: Article

References (27)