Temporally regulated assembly of a dynamic signaling complex associated with the activated TCR

European Journal of Immunology

Volumn 30, Issue 9, 2000, Pages 2620-2631

  Pacini, Sonia ^a   Valensin, Silvia ^a   Telford, John L ^b   Ladbury, John ^c   Baldari, Cosima T ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b CHIRON VACCINES   (Italy)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Protein; Protein interaction; Signaling complex; TCR; Temporal regulation

Indexed keywords

CD3 ANTIGEN; LIGAND; PROTEIN; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR; TYROSINE;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANIMAL; CARRIER PROTEINS; MEMBRANE PROTEINS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN-TYROSINE KINASE; PROTEINS; PROTO-ONCOGENE PROTEINS; RABBITS; RECEPTORS, ANTIGEN, T-CELL; SUPPORT, NON-U.S. GOV'T;

EID: 0033830057     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200009)30:9<2620::AID-IMMU2620>3.0.CO;2-Q     Document Type: Article

References (46)

1. Modular peptide recognition domains in eukaryotic signaling
2. From Src Homology domains to other signaling modules: Proposal of the 'protein recognition code'
3. Mass spectral and thermodynamic studies reveal the role of water molecules in complexes formed between SH2 domains and tyrosyl phosphopeptides
4. Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains
5. Searching for specificity in SH domains
6. Not all Shc's roads lead to Ras
7. Lymphocyte antigen receptor signal integration and regulation by the SHC adaptor
8. Signal transduction by lymphocyte antigen receptors
9. Regulation of antigen receptor signal transduction by protein tyrosine kinases
10. Molecular and genetic insigts into T cell antigen receptor structure and function
11. Antigen receptor tail clue
12. Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor ζ and CD3ε from activated Jurkat T cells
13. Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor
14. Binding of ZAP-70 to phosphorylated T-cell receptor ζ and η enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins
15. Interaction of Shc with the ζ chain of the T cell receptor upon T cell activation
16. The protein interactions of the immunoglobulin receptor family tyrosine-based activation motifs present in the T cell receptor ζ subunits and the CD3 γ, δ and ε chains
17. Complex complexes: Signaling at the TCR
18. Integration of T cell receptor-dependent signaling pathways by adapter proteins
19. The role of membrane-associated adaptors in T cell receptor signalling
20. Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation
21. Partial T cell signaling: Altered phospho-ζ and lack of zap70 recruitment in APL-induced T cell anergy
22. ζ Phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists
23. Fidelity of T cell activation through multistep T cell receptor ζ; phosphorylation
24. Phosphorylation of multiple CD3 ζ tyrosine residues leads to formation of pp21 in vitro and in vivo. Structural changes upon T cell receptor stimulation
25. Multiple components of the T cell antigen receptor complex become tyrosine-phosphorylated upon activation
26. ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR ζ in murine thymocytes and lymph node T cells
27. - thymocytes as a consequence of intrathymic interactions that diminish available p56lck
28. The aminoterminal phosphotyrosine binding domain of Shc associates with ZAP-70 and mediates TCR dependent gene activation
29. The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav
30. Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-γ1 and Ras activation
31. GRB2 and phospholipase C-γand 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation
32. LAT: The ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation
33. Tyrosine 474 of ZAP-70 is required for association with the Shc adaptor and for T-cell antigen receptor-dependent gene activation
34. The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70
35. Perturbed regulation of ZAP-70 and sustained tyrosine phosphorylation of LAT and SLP-76 in c-Cbl-deficient thymocytes
36. The Cbl protooncoprotein: A negative regulator of immune receptor signal transduction
37. Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation
38. The role of Grb2-associated proteins in T-cell activation
39. LAT palmitoylation: Its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation
40. Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains
41. Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor
42. Views on Vav
43. The real LAT steps forward
44. Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function
45. Negative regulation of antigen receptor signaling in lymphocytes
46. Membrane compartmentation is required for efficient T cell activation