Blood-endothelial cell and blood-brain transport of L-proline, α-aminoisobutyric acid, and L-alanine

Neurochemical Research

Volumn 21, Issue 10, 1996, Pages 1227-1235

  Benrabh, H ^a   Lefauconnier, J M ^a  

^a HÔPITAL FERNAND WIDAL   (France)

Author keywords

AIB; Alanine; Blood brain barrier; Brain perfusion technique; Proline; Rapidly reversible volumes

Indexed keywords

2 AMINO 2 METHYLPROPIONIC ACID; ALANINE; LEUCINE; PHENYLALANINE; PROLINE; SERINE;

AMINO ACID TRANSPORT; ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; BRAIN PERFUSION; ENDOTHELIUM CELL; MALE; MEMBRANE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; RAT; TRANSPORT KINETICS;

ALANINE; AMINOISOBUTYRIC ACIDS; ANIMALS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; ENDOTHELIUM, VASCULAR; MALE; MEMBRANES; PROLINE; RATS; RATS, SPRAGUE-DAWLEY; REGRESSION ANALYSIS;

ANIMALIA;

EID: 0029954955     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02532400     Document Type: Article

References (26)

1. Oldendorf, W. H. 1970. Measurement of brain uptake index of radiolabeled substances using tritiated water internal standard. Brain Res. 24:372-376.
2. Oldendorf, W. H., and Szabo, J. 1976. Amino acid assignment to one of three blood-brain barrier amino acid carriers. Am. J. Physiol. 230:94-98.
3. Oxender, D. L., and Christensen, H. N. 1963. Distinct mediating systems for the transport of neutral amino acids by the Ehrlich cell. J. Biol. Chem. 238:3686-3699.
4. Oldendorf, W. H. 1971. Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. Am. J. Physiol. 221:1629-1639.
5. Sershen, H., and Lajtha, A. 1979. Inhibition pattern by analogs indicates the presence of ten or more transport systems for amino acids in brain cells. J. Neurochem. 32:719-726.
6. +-requiring transport system for alanine, serine, cysteine and similar amino acids. J. Biol. Chem. 242:5237-5246.
7. Miller, L. P., Pardridge, W. M., Braun, L. D., and Oldendorf, W. H. 1985. Kinetic constants for blood-brain barrier amino acid transport in conscious rats. J. Neurochem. 45:1427-1432.
8. Takasato, Y., Rapoport, S. I., and Smith, Q. R. 1984. An in situ brain perfusion technique to study cerebrovascular transport in rat. Am. J. Physiol. 247:H484-H493.
9. Smith, Q. R., Momma, S., Aoyagi, M., and Rappoport, S. I. 1987. Kinetics of neutral amino acids transport across the blood-brain barrier. J. Neurochem. 49:1651-1658.
10. Patlak, C. S., Blasberg, R. G., and Fenstermacher, J. D. 1983. Graphical evaluation of blood to brain transfer constants from multiple-time uptake data. J. Cereb. Blood Flow Metab. 3:1-7.
11. Benrabh, H., Bourre, J. M., and Lefauconnier, J. M. 1995. Taurine transport at the blood-brain barrier: an in vivo brain perfusion study. Brain Res. 692:57-65.
12. Benrabh, H., and Lefauconnier J. M. 1996. Glutamate is transported across the blood-brain barrier by a sodium-independent system. Neurosc. Letters. In press.
13. Triguero, D., Buciak, J. B., and Pardridge, W. M. 1990. Capillary depletion method for quantification of blood-brain barrier transport of circulating peptides and plasma proteins. J. Neurochem. 54:1882-1888.
14. Ennis, S. R, Ren, X., and Betz, A. L. 1994. Transport of α-aminoisobutyric acid across the blood-brain barrier studied with in situ brain perfusion of rat brain. Brain Res. 643:100-107.
15. Rabin, O., Hegedus, L., Bourre, J. M., and Smith, Q. R. 1993. Rapid brain uptake of manganese across the blood-brain barrier. J. Neurochem. 61:3-9.
16. Fenstermacher, J., Blasberg, R., and Patlak, C. 1981. Methods for quantifying the transport of drugs across the brain barrier systems. Pharmacol. Ther. 14:217-248.
17. Wade, L. A., and Brady, H. M. 1981. Cysteine and cystine transport at the blood-brain-barrier. J. Neurochem. 37:730-734.
18. Tovar, A., Tews, J. K., Torres, N., and Harper, A. E. 1988. Some characteristics of threonine transport across the blood-brain barrier of the rat. J. Neurochem. 51:1285-1293.
19. Weissbach, I., Handlogten, M. E., Christensen, H. N., and Kilberg, M.S. 1982. Evidence for two Na-independent neutral amino acid transport systems in primary cultures of rat hepatocytes. J. Biol. Chem. 257:12006-12011.
20. +) of the rat blood-brain barrier. J. Neurochem. 60:1956-1959.
21. 14C]Proline by isolated rat brain capillaries, J. Neurochem. 40:317-323.
22. Gjedde, A. and Christensen, O. 1984. Estimates of Michaelis-Menten constants for the two membranes of the brain endothelium. J. Cereb. Blood Flow Metab. 4:241-249.
23. Blasberg, R. G., Fenstermacher, J. D., and Patlack, C. S. 1983. Transport of α-aminoisobutyric acid across brain capillary and cellular membranes. J. Cereb. Blood Flow Metab. 3:8-32.
24. Banks, W. A., and Broadwell, R. D. 1994. Blood to brain and brain to blood passage of native horseradish peroxidase, wheat germ agglutinin: pharmacokinetic and morphological assessments. J. Neurochem. 62:2404-2419.
25. Banderali, U., and Roy, G. 1992. Anion channels for amino acids in MDCK cells. Am. J. Physiol. 263:C1200-C1207.
26. Haynes, J. K., and Goldstein, L. 1993. Volume-regulatory amino acid transport in erythrocytes of the little skate, Raja erinacea. Am. J. Physiology, 265:R173-R179.