Establishment of a novel in vitro system for studying the interaction of xenobiotic metabolism of liver and intestinal microflora

Archives of Toxicology

Volumn 74, Issue 7, 2000, Pages 379-387

  Laube, B ^a   Winkler, S ^a   Ladstetter, B ^b   Scheller, T ^b   Schwarz, L R ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b MERCK KGAA   (Germany)

Author keywords

7 Ethoxycoumarin; Coculture system; Drug metabolism; Hepatocytes; Intestinal microflora

Indexed keywords

3 HYDROXYBENZO[A]PYRENE; 5 [1 (3,4 DIMETHOXYBENZOYL) 1,2,3,4 TETRAHYDRO 6 QUINOLYL] 3,6 DIHYDRO 6 METHYL 2H 1,3,4 THIADIAZIN 2 ONE; 7 ETHOXYCOUMARIN; BETA GLUCOSIDASE; BETA GLUCURONIDASE; BIOCHEMICAL MARKER; CYTOCHROME P450 ISOENZYME; LIVER ENZYME; NITROREDUCTASE; SULFATASE; TESTOSTERONE; XENOBIOTIC AGENT;

ADULT; AEROBIC METABOLISM; ANAEROBIC METABOLISM; ANIMAL CELL; ARTICLE; COCULTURE; CONJUGATION; DEALKYLATION; DIET; DRUG METABOLISM; ENZYME ACTIVITY; FEMALE; HUMAN; HYDROXYLATION; IN VITRO STUDY; INTESTINE FLORA; LIVER CELL; LIVER METABOLISM; MALE; NONHUMAN; NORMAL HUMAN; OXIDATION; PRIORITY JOURNAL; RAT; XENOBIOTIC METABOLISM;

ADULT; AEROBIOSIS; ANIMAL; BACTERIA, ANAEROBIC; BIOTRANSFORMATION; COUMARINS; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; GLYCOSIDE HYDROLASES; HEPATOCYTES; HUMAN; IN VITRO; INTESTINES; MALE; OXIDOREDUCTASES; QUINOLINES; RATS; RATS, WISTAR; SULFATASES; SUPPORT, NON-U.S. GOV'T; THIADIAZINES;

ANIMALIA;

EID: 0033826022     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040000137     Document Type: Article

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