New aspects in the pathogenesis of bullous pemphigoid;Neue aspekte zur pathogenese des bullosen pemphigoids

Hautarzt

Volumn 51, Issue 9, 2000, Pages 637-645

  Schmidt, E ^a   Brocker E B ^a   Zillikens, D ^a  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

Author keywords

Autoantigen; BP180; Cytokine; ELISA; Mouse model

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; BULLOUS PEMPHIGOID ANTIGEN 1; COMPLEMENT; CYTOKINE; MEMBRANE PROTEIN; PROTEIN BP120; UNCLASSIFIED DRUG;

AGING; AMINO ACID COMPOSITION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY DETECTION; AUTOIMMUNE DISEASE; COMPLEMENT ACTIVATION; CONTROLLED STUDY; CORRELATION FUNCTION; CYTOKINE PRODUCTION; DISEASE ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEMIDESMOSOME; INFLAMMATORY CELL; MOUSE; NONHUMAN; PATHOGENESIS; PEMPHIGOID; PEMPHIGUS; PROTEIN DOMAIN; PROTEIN LOCALIZATION; REVIEW;

ANIMALS; ANIMALS, NEWBORN; AUTOANTIBODIES; AUTOANTIGENS; CARRIER PROTEINS; COLLAGEN; CYTOSKELETAL PROTEINS; HUMANS; MICE; NERVE TISSUE PROTEINS; NON-FIBRILLAR COLLAGENS; PEMPHIGOID, BULLOUS; RABBITS; SKIN;

EID: 0033824481     PISSN: 00178470     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001050051188     Document Type: Review

References (82)

1. 180-kD bullous pemphigoid antigen/type XVII collagen: Tissue-specific expression and molecular interaction with keratin 18
2. Immunphanotypisierung des mononuklaren infiltrats beim bullosen pemphigoid
3. Cytokine pattern in blister fluid and serum of patients with bullous pemphigoid: Relationships with disease intensity
4. Pathogenic effects of bullous pemphigoid autoantibodies on rabbit corneal epithelium
5. Drugs associated with bullous pemphigoid
6. The major cicatricial pemphigoid antigen is a 180-kD protein that shows immunologic cross-reactivities with the bullous pemphigoid antigen
7. Incidence and distribution of subepidermal autoimmune bullous skin disease in three French regions
8. Anti-BP180 autoantibodies as a marker of poor prognosis in BP: A cohort analysis of 94 elderly patients
9. Subclass distribution of IgG autoantibodies in bullous pemphigoid
10. Structure and function of hemidesmosomes: More than simple adhesion complexes
11. Lichen planus pemphigoides is a heterogenous disease: A report of five cases studied by immunoelectron microscopy
12. Identification and characterization of autoreactive T cell responses to bullous pemphigoid antigen 2 in patients and heatlthy controls
13. Bullous pemphigoid: A cause of peripheral blood eosinphilia
14. 3 are the major immunoglobulin subclasses targeting epitopes within BP180 NC16A in pemphigoid gestationis
15. Interleukin-4 and interleukin-13: Their similarities and discrepancies
16. IgE autoantibodies directed against the major bullous pemphigoid antigen in patients with a severe form of pemphigoid
17. A common major histocompatibility complex class II allele HLA-DQB1*0301 is present in clinical variants of pemphigoid
18. Isolation of human epidermal cDNA corresponding to the 180-kDa autoantigen recognized by bullous pemphigoid and herpes gestationis sera
19. 4 and IgE are the major immunoglobulins targeting the NC16 A domain of BP180 in bullous pemphigoid: Serum levels reflect disease activity
20. An in vitro model of immune complex-mediated basement membrane zone separation caused by pemphigoid antibodies, leukocytes, and complement
21. Cloning and primary structural analysis of the bullous pemphigoid autoantigen BP180
22. Gene targeting of BPAG1: Abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration
23. Detection of IgG autoantibodies in the sera of patients with bullous and gestational pemphigoid: ELISA studies utilizing baculovirus-encoded form of bullous pemphigoid antigen 2
24. Rabbits immunized with a peptide encoded for by the 230-kD bullous pemphigoid antigen cDNA develop an enhanced inflammatory response to UVB irradiation: A potential animal model for bullous pemphigoid
25. Cleavage of BP180, a 180-kDa bullous pemphigoid antigen, yields a 120-kDa collagenous extracellular polypeptide
26. Molecular genetic studies of a human epidermal autoantigen (the 180-kD bullous pemphigoid antigen/BP180): Identification of functionally important sequences within the BP180 molecule and evidence for an interaction between BP180 and α6 integrin
27. Increased serum levels of IL-5, IL-6, and IL-8 in bullous pemphigoid
28. 180-kD bullous pemphigoid antigen (BP180) is deficient in generalized atrophic benign epidermolysis bullosa
29. Basement membrane antibodies in bullous pemphigoid
30. Immunopathologic mechanisms in pemphigus and bullous pemphigoid
31. Increased risk of bullous pemphigoid in male and very old patients. A population-based study on incidence
32. The use of chemically split tissue in the detection of circulating anti-basement membrane zone antibodies in bullous pemphigoid and cicatricial pemphigoid
33. Immunpathologische veranderungen bei 115 patienten mit bullosem pemphigoid
34. Bullous pemphigoid. The latest in diagnosis, prognosis, and therapy
35. Molecular heterogeneity of the bullous pemphigoid antigens as detected by immunoblotting
36. A passive transfer mouse model of the organ-specific autoimmune disease, bullous pemphigoid, using antibodies generated against the hemidsmosomal antigen, BP180
37. Molecular mapping of a pathogenically relevant BP180 epitope associated with experimentally induced murine bullous pemphigoid
38. The role of complement in experimental bullous pemphigoid
39. A major role for neutrophils in experimental bullous pemphigoid
40. Interleukin-1 and -6 are required for subepidermal blistering in experimental bullous pemphigoid
41. Gelatinase B-deficient mice are resistant to experimental bullous pemphigoid
42. The extracellular domain of the lamina densa of BPAG2 localizes to anchoring filaments and its carboxy terminus extends to the lamina densa of normal human epidermal basement membrane
43. Mutations in the 180-kD bullous pemphigoid antigen (BPAG2), a hemidesmosomal transmembrane collagen (COL17A1) in generalized atrophic benign epidermolysis bullosa
44. IgG antibodies from patients with bullous pemphigoid bind to fusion proteins encoded by BPAg1 cDNA
45. Herpes gestationis antibodies recognize a 180-kD human epidermal antigen
46. A 230-kD basic protein is the major bullous pemphigoid antigen
47. The pathogenic mechanisms of blister formation in bullous pemphigoid
48. Immunoreactivity of bullous pemphigoid (BP) autoantibodies against the NC16A and C-terminal domains of the 180 kDa BP antigen (BP180): Immunoblot analysis and enzyme-linked immunosorbent assay using BP180 recombinant proteins
49. IgA antibodies of cicatricial pemphigoid sera specifically react with C-terminus of BP180
50. Serum IgE antibodies bind to the epidermal side of the basement membrane zone splits in bullous pemphigoid
51. Bullous pemphigoid: Serum antibody titre and antigen specificity
52. Bullous pemphigoid and linear IgA dermatosis sera recognize a similar 120-kDa keratinocyte collagenous glycoprotein with antigenic cross-reactivity to BP180
53. IgG autoantibodies from bullous pemphigoid (BP) patients bind antigenic sites on both the extracellular and the intracellular domains of the BP antigen 180
54. The extracellular domain of BP180 binds laminin 5
55. Characterization of skin cytokines in bullous pemphigoid and pemphigus vulgaris
56. Failure to transfer bullous pemphigoid with serum from patients
57. Two forms of collagen XVII in keratinocytes. A full-length transmembrane protein and a soluble ectodomain
58. High levels of soluble CD23 in blister fluid of bullous pemphigoid
59. Elevated levels of interleukin-8 in blister fluid of bullous pemphigoid compared with suction blisters of healthy controls
60. Detection of elevated levels of IL-4, IL-6, and IL-10 in blister fluid of bullous pemphigoid
61. Detection of IL-1α, IL-1β, and IL-1 receptor antagonist in blister fluid of bullous pemphigoid
62. Levels of autoantibodies to BP180 correlate with disease activity in patients with bullous pemphigoid
63. Linear IgA disease with circulating IgA antibodies against the NC16A domain of BP180
64. Antibodies to BP180 induce the release of IL-6 and IL-8 from cultured normal human keratinocytes
65. Three novel homozygos point mutations and a new polymorphism in the COL17A1 gene: Relation to biological and clinical phenotype of junctional epidermolysis bullosa
66. BP180 gene delivery in junctional epidermolysis bullosa
67. Regional variations in antigenic properties of skin. A possible cause for disease-specific distribution of skin lesions
68. Characterization of bullous pemphigoid antigen: A unique basement membrane protein of stratified epithelia
69. Isolation of complementary DNA for bullous pemphigoid antigen by use of patients' autoantibodies
70. Bulloses pemphigoid unter dem bild einer prurigo simplex subacuta
71. Elevated levels of soluble tumor necrosis factor receptor I in blister fluid of bullous pemphigoid and suction blisters
72. The interleukin-2 receptor in lesions and serum of bullous pemphigoid
73. Tumor necrosis factor in blister fluids of bullous pemphioid
74. Incidence of autoimmune subepidermal blistering diseases in a region of central Germany
75. Bullous pemphigoid. An autoimmune blistering disease of the elderly
76. Tight clustering of extracellular BP180 epitopes recognized by bullous pemphigoid autoantibodies
77. A highly sensitive enzyme-linked immunosorbent assay for the detection of circulating anti-BP180 autoantibodies in patients with bullous pemphigoid
78. Acquired skin disease of hemidesmosomes
79. Antibodies in lichen planus pemphigoides react with a novel epitope within the C-terminal NC16A domain of BP180
80. BP180/type XVII collagen: Its role in acquired and inherited disorders of the dermal-epidermal junction
81. Autoantibodies in a subgroup of patients with linear IgA disease react with the NC16A domain of BP180
82. The 97-kDa linear IgA bullous disease antigen is identical to a portion of the extracellular domain of the 180-kDa bullous pemphigoid antigen, BPAg2