Bullous pemphigoid and linear IgA dermatosis sera recognize a similar 120-kDa keratinocyte collagenous glycoprotein with antigenic cross-reactivity to BP180

Journal of Investigative Dermatology

Volumn 108, Issue 4, 1997, Pages 423-429

  Pas, Hendri H ^a,b   Kloosterhuis, Guus J ^a   Heeres, Klaas ^a   Van Der Meer, Jan B ^a   Jonkman, Marcel F ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

autoantigen; junctional epidermolysis bullosa; LAD 1; type XVII collagen

Indexed keywords

AUTOANTIGEN; COLLAGEN; GLYCOPROTEIN;

ARTICLE; CROSS REACTION; HUMAN; HUMAN CELL; KERATINOCYTE; PEMPHIGOID; PRIORITY JOURNAL; PROTEIN ANALYSIS; SERUM; SKIN DISEASE;

EID: 0030964050     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/1523-1747.ep12289703     Document Type: Article

References (28)

1. Bruins S, de Jong MC, Heeres K, Wilkinson MH, Jonkman MF, van der Meer JB: Fluorescence overlay antigen mapping of the epidermal basement membrane zone: I. Geometric errors. J Histochem Cytochem 42:555-560, 1994
2. Bruins S, de Jong MC, Heeres K, Wilkinson MH, Jonkman MF, van der Meer JB: Fluorescence overlay antigen mapping of the epidermal basement membrane zone: II. Color fidelity. J Histochem Cytochem 43:715-722, 1995a
3. Bruins S, de Jong MC, Heeres K, Wilkinson MH, Jonkman MF, van der Meer JB: Fluorescence overlay antigen mapping of the epidermal basement membrane zone: III. Topographic staining and effective resolution, J Histochem Cytochem 43:649-656, 1995b
4. de Jong MC, Bruins S, Heeres K, Jonkman MF, Niehoer C, Boorsma DM, Pas HH, van der Meer JB: Bullous pemphigoid and epidermolysis bullosa acquisita. Differentiation by fluorescence overlay antigen mapping. Arch Dermatol 132:151-157, 1996
5. Diaz LA, Calvanico NJ, Tomasi TBJ, Jordon RE: Bullous pemphigoid antigen: isolation from normal human skin. J Immunol 118:455-460, 1977
6. Gao SQ, Bystryn JC: A novel bullous pemphigoid antigen (BP125) located in the deeper layers of the basement membrane zone. Arch Dermatol 130:873-878, 1994
7. Giudice GJ, Emery DJ, Diaz LA: Cloning and primary structural analysis of the bullous pemphigoid autoantigen BP180. J Invest Dermatol 99:243-250, 1992
8. Haftek M, Zone JJ, Taylor TB, Kowalewski C, Chorzelski TP. Schmitt D: Immuno-gold localization of the 97-kD antigen of linear IgA bullous dermatosis (LABD) detected with patients' sera. J Invest Dermatol 103:656-659, 1994
9. Hall RP III, Murray JC, McCord MM, Rico MJ, Streilein RD: Rabbits immunized with a peptide encoded for by the 230-kD bullous pemphigoid antigen cDNA develop an enhanced inflammatory response to UVB irradiation: a potential animal model for bullous pemphigoid. J Invest Dermatol 101:9-14, 1993
10. Hopkinson SB, Riddelle KS, Jones JC; Cytoplasmic domain of the 180-kD bullous pemphigoid antigen, a hemidesmosomal component: molecular and cell biologic characterization. J Invest Dermatol 99:264-270, 1992
11. Ishiko A, Shimizu H, Kikuchi A, Ebihara T, Hashimoto T, Nishikawa T: Human autoantibodies against the 230-kD bullous pemphigoid antigen (BPAG1) bind only to the intracellular domain of the hemidesmosome, whereas those against the 180-kD bullous pemphigoid antigen (BPAG2) bind along the plasma membrane of the hemidesmosome in normal human and swine skin. J Clin Invest 91:1608-1615, 1993
12. Ishiko A, Shimizu H, Masunaga T, Hashimoto T, Dmochowski M, Wojnarowska F, Bhogal BS, Black MM, Nishikawa T-. 97-kDa linear IgA bullous dermatosis (LAD) antigen, localizes to the lamina lucida of the epidermal basement membrane, J invest Dermatol 106:739-743, 1996
13. Jonkman MF, de Jong MCJM, Heeres K, Pas HH, van der Meer JB, Owaribe K, Martinez de Velasco AM, Niessen CM, Sonnenberg A: 180-kD bullous pemphigoid antigen (BP180) is deficient in generalized atrophic benign epidermolysis bullosa. J Clin Invest 95:1345-1352, 1995
14. Jonkman MF, de Jong MC, Heeres K, Steijlen PM, Owaribe K, Kuster W, Meurer M, Gedde Dahl T Jr, Sonnenberg A, Bruckner Tuderman L; Generalized atrophic benign epidermolysis bullosa. Either 180-kd bullous pemphigoid antigen or laminin-5 deficiency. Arch Dermatol 132:145-150, 1996a
15. Jonkman MF, Heeres K, Pas HH, Van Luyn MJA, Elema JD, Corden L, Smith FJD, McLean WHI, Ramaekers FCS, Burton M, Scheffer H: Effects of keratin 14 ablation on the clinical and cellular phenotype in a kindred with recessive epidermolysis bullosa simplex. J Invest Dermatol 107:764-769, 1996b
16. Labib RS, Anhalt GJ, Patel HP, Mutasim DF, Diaz LA: Molecular heterogeneity of the bullous pemphigoid antigens as detected by immunoblotting. J Immnnol 136; 1231-1235, 1986
17. Li KH, Sawamura D, Giudice GJ, Diaz LA, Mattei MG, Chu ML, Uitto J: Genomic organization of collagenous domains and chromosomal assignment of human 180-kDa bullous pemphigoid antigen-2, a novel collagen of stratified squamous epithelium. J Biol Chem 266:24064-24069, 1991
18. Liu Z, Diaz LA, Troy JL, Taylor AF, Emery DJ, Fairley JA, Giudice GJ: A passive transfer model of the organ-specific autoimmune disease, bullous pemphigoid, using antibodies generated against the hemidesmosomal antigen, BP180. J Clin Invest 92:2480-2488, 1993
19. Marinkovich MP, Taylor TB, Keene DR, Burgeson RE, Zone JJ: LAD-1, the linear IgA bullous dermatosis autoantigen, is a novel 120-kDa anchoring filament protein synthesized by epidermal cells. J Invest Dermatol 106:734-738, 1996
20. Meyer LJ, Taylor TB, Kadunce DP, Zone JJ: Two groups of bullous pemphigoid antigens are identified by affinity-purified antibodies. J Invest Dermatol 94:611-616, 1990
21. Meyer LJ, Taylor TB, Kadunce DP, Thuong-Nguyen V, Zone JJ: Bullous pemphigoid antigens: extraction and degradation of antigens during epidermal preparation. J Invest Dermatol 96:991-993, 1991
22. Mitra R, Nickoloff BJ: Cultivation at human epidermal keratinocytes in serum-free growth medium. In: Leigh IM, Watt FM, (eth.). Keratinocyte Methods. Cambridge University Press, Cambridge, United Kingdom, 1994, pp 17-19
23. Nishizawa Y, Uematsu J, Owaribe K: HD4, a 180 kDa bullous pemphigoid antigen, is a major trarismembrane glycoprotein of the hemidesmosome. J Biochem (Tokyo) 113:493-501, 1993
24. Pas HH, de Jong MC, Jonkman MF, Heeres K, Slijper Pal IJ, van der Meer JB. Bullous pemphigoid: serum antibody titre and antigen specificity. Exp Dermatol 4:372-376, 1995
25. Sawamura D, Nomura K, Sugita Y, Mattei MG, Chu ML. Knowlton R, Uitto J: Bullous pemphigoid antigen (BPAGl): cDNA cloning and mapping of the gene to the short arm of human chromosome 6. Genomca 8:722-726,1990
26. Stanley JR, Hawley-Nelson P, Yuspa SH, Shevach EM, Katz SI: Characterization of bullous pemphigoid antigen: A unique basement membrane protein of stratified squamous epithelia. Cell 24:897-903, 1981
27. Zambruno G, Manca V, Kanitakis J, Cozzani E, Nicolas JF, Giannetti A: Linear IgA bullous dermatosis with autoantibodies to a 290 kd antigen of anchoring fibrils. J Am Acad Dermatol 31:884-888, 1994
28. Zone JJ, Taylor TB, Kadunce DP, Meyer LJ: Identification of the cutaneous basement membrane zone antigen and isolation of antibody in linear immunoglobulin A bullous dermatosis. J Clin Invest 85:812-820, 1990