The selective dopamine D4 receptor antagonist, PNU-101387G, prevents stress-induced cognitive deficits in monkeys

Neuropsychopharmacology

Volumn 23, Issue 4, 2000, Pages 405-410

  Arnsten, Amy F T ^a   Murphy, Beth ^a   Merchant, Kalpana ^b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PFIZER INC   (United States)

Author keywords

D4 receptors; Dopamine; FG7142K; Memory; Prefrontal cortex; Stress

Indexed keywords

8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; DOPAMINE 1 RECEPTOR; DOPAMINE 4 RECEPTOR; DOPAMINE 4 RECEPTOR BLOCKING AGENT; DOPAMINE RECEPTOR BLOCKING AGENT; N METHYL BETA CARBOLINE 3 CARBOXAMIDE; SONEPIPRAZOLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; DRUG SELECTIVITY; FEMALE; MEMORY; MENTAL STRESS; NEUROMODULATION; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; PSYCHOPHARMACOLOGY; RHESUS MONKEY; TASK PERFORMANCE;

ANIMALS; CARBOLINES; COGNITION; DOPAMINE ANTAGONISTS; FEMALE; GABA ANTAGONISTS; MACACA MULATTA; MEMORY; PIPERAZINES; PREFRONTAL CORTEX; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4; STRESS, PSYCHOLOGICAL; SULFONAMIDES;

EID: 0033824142     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0893-133X(00)00133-0     Document Type: Article

References (24)

1. Arnsten A.F.T. Catecholamine regulation of the prefrontal cortex. J Psychopharmacology. 11:1997;151-162.
2. Arnsten A.F.T., Goldman-Rakic P.S. Noise stress impairs prefrontal cortical cognitive function in monkeys. Evidence for a hyperdopaminergic mechanism Arch Gen Psychiatry. 55:1998;362-369.
3. Birnbaum S., Gobeske K.T., Auerbach J., Taylor J.R., Arnsten A.F.T. A role for norepinephrine in stress-induced cognitive deficits. Alpha-1-adrenoceptor mediation in the prefrontal cortex Biol Psychiatry. 46:1999;1266-1274.
4. Broadbent D. Decision and Stress. 1971;Academic Press, London.
5. Goldman P.S., Rosvold H.E. Localization of function within the dorsolateral prefrontal cortex of the rhesus monkey. Exp Neurol. 27:1970;291-304.
6. Goldman-Rakic P.S. Circuitry of the primate prefrontal cortex and the regulation of behavior by representational memory. Plum F. Handbook of Physiology, The Nervous System, Higher Functions of the Brain, vol V. 1987;373-417 American Physiological Society, Bethesda, MD.
7. Goldman-Rakic P.S., Brown R.M. Regional changes of monoamines in cerebral cortex and subcortical structures of aging rhesus monkeys. Neuroscience. 6:1981;177-187.
8. Goldstein L.E., Rasmusson A.M., Bunney S.B., Roth R.H. Role of the amygdala in the coordination of behavioral, neuroendocrine and prefrontal cortical monoamine responses to psychological stress in the rat. J Neurosci. 16:1996;4787-4798.
9. Hartley L.R., Adams R.G. Effect of noise on the Stroop test. J Exp Psychol. 102:1974;62-66.
10. Kaneyuki H., Yokoo H., Tsuda A., Yoshisa M., Mizuki Y., Yamada M., Tanaka M. Psychological stress increases dopamine turnover selectively in mesoprefrontal dopamine neurons of rats. Reversal by diazepam Brain Res. 557:1991;154-161.
11. Lanau F., Zenner M.-T., Civelli O., Hartman D.S. Epinephrine and norepinephrine act as potent agonists at the recombinant human dopamine D4 receptor. J Neurochem. 68:1997;804-812.
12. Lewis D.A. Development of the prefrontal cortex during adolescence. Insights into vulnerable neural circuits in schizophrenia Neuropsychopharmacology. 16:1997;385-398.
13. Lidow M.S., Wang F., Cao Y., Goldman-Rakic P.S. Layer V pyramidal neurons bear the majority of mRNAs encoding the five distinct dopamine receptor subtypes in the primate prefrontal cortex. Synapse. 28:1998;10-20.
14. Mazure C.M. Does stress cause psychiatric illness? Spiegel D. Progress in Psychiatry, vol. 46. 1995;American Psychiatric Press, p 270, Washington, DC.
15. Merchant K.M., Gill G.S., Harris D.W., Huff R.M., Eaton M.J., Lookingland K., Lutzke B.S., McCall R.B., Piercey M.F., Schreur P.J., Sethy V.H., Smith M.W., Svensson K.A., Tang A.H., Vonvoigtlander P.F., Tenbrink R.E. Pharmacological characterization of U-101387, a dopamine D4 receptor selective antagonist. J Pharmacol Exp Ther. 279:1996;1392-1403.
16. Mrzljak L., Bergson C., Pappy M., Levenson R., Huff R., Goldman-Rakic P.S. Localization of dopamine D4 receptors in GABAergic neurons of the primate brain. Nature. 381:1996;245-248.
17. Murphy B., Roth R., Arnsten A.F.T. Clozapine reverses the spatial working memory deficits induced by FG7142 in monkeys. Neuropsychopharmacology. 16:1997;433-437.
18. Murphy B.L., Arnsten A.F.T., Goldman-Rakic P.S., Roth R.H. Increased dopamine turnover in the prefrontal cortex impairs spatial working memory performance in rats and monkeys. Proc Nat Acad Sci USA. 93:1996;1325-1329.
19. Primus R.J., Thurkauf A., Xu J., Yevich E., McInerney S., Shaw K., Tallman J.F., Gallagher D.W. II. Localization and characterization of dopamine D4 binding sites in rat and human brain by use of the novel, D4 receptor-selective ligand [3H]NGD 94-1. J Pharmacol Exp Ther. 282:1997;1020-1027.
20. Rosenberg D.R., Lewis D.A. Changes in the dopaminergic innervation of monkey prefrontal cortex during late postnatal development. A tyosine hydroxylase immunohistochemical study Biol Psychiat. 36:1994;272-277.
21. Thierry A.M., Tassin J.P., Blanc G., Glowinski J. Selective activation of the mesocortical DA system by stress. Nature. 263:1976;242-244.
22. Van Tol H.H.M., Bunzow J.R., Guan H.-C., Sunahara R.K., Seeman P., Niznik H.B., Civelli O. Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine. Nature. 350:1991;610-614.
23. Wenk G.L., Pierce D.J., Struble R.G., Price D.L., Cork L.C. Age-related changes in multiple neurotransmitter systems in the monkey brain. Neurobio Aging. 10:1989;11-19.
24. Zahrt J., Taylor J.R., Mathew R.G., Arnsten A.F.T. Supranormal stimulation of dopamine D1 receptors in the rodent prefrontal cortex impairs spatial working memory performance. J Neurosci. 17:1997;8528-8535.