The functional significance of Shc in insulin signaling as a substrate of the insulin receptor

Endocrine Journal

Volumn 47, Issue 4, 2000, Pages 373-381

  Sasaoka, Toshiyasu ^a   Kobayashi, Masashi ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; DNA; EPIDERMAL GROWTH FACTOR RECEPTOR; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PHOSPHOTYROSINE; PROTEIN P21; PROTEIN TYROSINE KINASE; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG;

DNA SYNTHESIS; GLUCOSE METABOLISM; GLYCOGEN SYNTHESIS; HUMAN; MITOGENESIS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION;

EID: 0033823488     PISSN: 09188959     EISSN: None     Source Type: Journal    
DOI: 10.1507/endocrj.47.373     Document Type: Review

References (37)

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3. A novel transforming protein (Shc) with an SH2 domain is implicated in mitogenic signal transduction
4. Opposite effects of the p52(Shc)/p46(Shc) and p66(Shc) splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway
5. N-Shc and Sck, two neuronally expressed Shc adapter homologs: Their differential regional expression in the brain and roles in neurotrophin and src signaling
6. A mammalian adaptor protein with conserved src homology 2 and phosphotyrosine-binding domain is related to Shc and is specifically expressed in the brain
7. A novel pathway from phosphorylation of tyrosine residues 239/240 of Shc, contributing to suppress apoptosis by IL-3
8. The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions
9. Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from ras/mitogen-activated protein kinase activation
10. A Drosophila Shc gene product is implicated in signaling by the DER receptor tyrosine kinase
11. Functional importance of Shc tyrosine 317 on insulin signaling in rat1 fibroblasts expressing insulin receptors
12. Relative involvement of Shc tyrosine 239/240 and tyrosine 317 on insulin induced mitogenic signaling in rat1 fibroblasts expressing insulin receptors
13. Functional importance of amino-terminal domain of Shc for interaction with insulin and epidermal growth factor receptors in phosphorylation independent manner
14. Phosphotyrosine-dependent interaction of Shc and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain
15. Distinct modes of interaction of Shc and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains
16. Shc is the predominant signaling molecule coupling insulin receptors to activation of guanine nucleotide releasing factor and p21ras-GTP formation
17. The signaling pathway coupling epidermal growth factor receptors to activation of p21ras
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19. Insulin and epidermal growth factor influence guanine nucleotide-releasing factor by distinct mechanisms
20. Shc proteins are localized on endoplasmic reticulum membranes and are redistributed after tyrosine kinase receptor activation
21. Negative feedback regulation and desensitization of insulin- and epidermal growth factor-stimulated p21ras activation
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23. Comparison of the insulin and insulin-like growth factor 1 mitogenic intracellular signaling pathways
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27. Interaction of Shc with adaptor protein adaptins
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30. Molecular cloning of rat SH2-containing inositol phosphatase 2 (SHIP2) and its role in the regulation of insulin signaling
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32. Shc isoform-specific tyrosine phosphorylation by the insulin and epidermal growth factor receptors
33. The 66-kDa Shc isoform is a negative regulator of the epidermal growth factor-stimulated mitogen-activated protein kinase pathway
34. The p66(Shc) adaptor protein controls oxidative stress response and life span in mammals
35. Insulin stimulates the phosphorylation of the 66- and 52-kilodalton Shc isoforms by distinct pathways
36. Evidence for a direct interaction between insulin receptor substrate-1 and Shc
37. Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in type 2 diabetes