Genetic analysis of chromosome 2 in type 1 diabetes: Analysis of putative loci IDDM7, IDDM12, and IDDM13 and candidate genes NRAMP1 and IA-2 and the interleukin-1 gene cluster

Diabetes

Volumn 47, Issue 11, 1998, Pages 1797-1799

  Esposito, Laura ^a   Hill, Natasha J ^a   Pritchard, Lynn E ^a   Cucca, Francesco ^a   Muxworthy, Claire ^a   Merriman, Marilyn E ^a   Wilson, Amanda ^a   Julier, Cecile ^b   Delepine, Marc ^b   Tuomilehto, Jaakko ^d   Tuomilehto Wolf, Eva ^d   Ionesco Tirgoviste, Constantin ^e   Nistico, Lorenza ^f   Buzzetti, Raffaella ^g   Pozzilli, Paolo ^g   Ferrari, Maurizio ^h   Bosi, Emanuele ^h   Pociot, Flemming ⁱ   Nerup, Jörn ⁱ   Bain, Stephen C ^c   Todd, John A ^a,j   more..

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

^d NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^e Clin of Nutr and Metabolic Disease   (Romania)

^f CNR   (Italy)

^g SAPIENZA UNIVERSITY OF ROME   (Italy)

^h SAN RAFFAELE HOSPITAL   (Italy)

ⁱ STENO DIABETES CENTER   (Denmark)

^j ADDENBROOKE S HOSPITAL   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1;

ARTICLE; CHROMOSOME 2; GENE CLUSTER; GENETIC ANALYSIS; GENETIC LINKAGE; GENETIC POLYMORPHISM; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL;

CHROMOSOMES, HUMAN, PAIR 2; DENMARK; DIABETES MELLITUS, TYPE 1; FINLAND; FRANCE; GREAT BRITAIN; HUMANS; INTERLEUKIN-1; ITALY; LINKAGE (GENETICS); MICROSATELLITE REPEATS; MULTIGENE FAMILY; ROMANIA; UNITED STATES;

EID: 0031720530     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.47.11.1797     Document Type: Article

References (16)

1. Cornall RJ, Prins JB, Todd JA, Pressey A, DeLarato NH, Wicker LS, Peterson LB: Type 1 diabetes in mice is linked to the interleukin-1 receptor and Lsh/Ity/Bcg genes on chromosome 1. Nature 353:262-265, 1996
2. Copeman JB, Cucca F, Hearne CM, Cornall RJ, Reed PW, Rønningen KS, Undlien DE, Nistico L, Buzzetti R, Tosi R, Pociot F, Nerup J, Cornélis F, Barnett AH, Bain SC, Todd JA: Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to human chromosome 2q31-q33. Nat Genet 9:80-85, 1995
3. Owerbach D, Gabbay KH: The HOXD8 locus (2q31) is linked to type I diabetes: interaction with chromosome 6 and 11 disease susceptibility genes. Diabetes 44:132-136, 1995
4. Nistico' L, Buzzetti R, Pritchard LE, Van der Auwera B, Giovannini C, Bosi E, Larrad MT, Rios MS, Chow CC, Cockram CS, Jacobs K, Mijovic C, Bain SC, Barnett AH, Vandewalle CL, Schuit F, Gorus FK, Registry BD, Tosi R, Pozzilli P, Todd JA: The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Hum Mol Genet 5:1075-1080, 1996
5. Morahan G, Huang D, Tait BD, Colman PG, Harrison LC: Markers on distal chromosome 2q linked to insulin-dependent diabetes mellitus. Science 272:1811-1813, 1996
6. Bain SC, Todd JA, Barnett AH: The British Diabetic Association: Warren repository. Autoimmunity 7:83-85, 1990
7. Spielman R, McGinnis R, Ewens W: Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 52:506-516, 1993
8. Luo D-F, Buzzetti R, Rotter JI, Maclaren NK, Raffael LJ, Nistico' L, Giovannini C, Pozzilli P, Thomson G, She J-X: Confirmation of three susceptibility genes to insulin-dependent diabetes mellitus: IDDM4, IDDM5 and IDDM8. Hum Mol Genet 5:693-698, 1996
9. Marron MP, Raffel LJ, Garchon HJ, Jacob CO, Serrano-Rios M, Martinez Larrad MT, Teng WP, Park Y, Zhang ZX, Goldstein DR, Tao YW, Beaurain G, Bach JF, Huang HS, Luo DF, Zeidler A, Rotter JI, Yang MC, Modilevsky T, Maclaren NK, She J-X: Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA-4 polymorphisms in multiple ethnic groups. Hum Mol Genet 6:1275-1282, 1997
10. Martin ER, Kaplan NL, Weir BS: Tests for linkage and association in nuclear families. Am J Hum Genet 61:438-448, 1997
11. Awata T, Kurihara S, Iitaka M, Takei S, Inoue I, Ishii C, Negishi K, Izumida T, Yoshida Y, Hagura R, Kuzuya N, Kanazawa Y, Katayama S: Association of CTLA-4 gene A-G polymorphism (IDDM12 locus) with acute-onset and insulin-depleted IDDM as well as autoimmune thyroid disease (Graves' disease and Hashimoto's thyroiditis) in Japanese population. Diabetes 47:128-129, 1998
12. Fu J, Ikegami H, Kawaguchi Y, Fujisawa T, Kawabata Y, Hamada Y, Ueda H, Shintani M, Nojima K, Babaya N, Shen Q-J, Uchigata Y, Urakami T, Omori Y, Shima K, Ogihara T: Association of distal chromosome 2q with IDDM in Japanese subjects. Diabetologia 41:228-232, 1998
13. Bonifacio E, Lampasona V, Genovese S, Ferrari M, Bosi E: Identification of protein tyrosine phosphatase-like IA2 (islet cell antigen 512) as the insulin-dependent diabetes-related 37/40K autoantigen and a target of islet-cell antibodies. J Immunol 155:5419-5426, 1995
14. Shaw M-A, Clayton D, Atkinson SE, Williams H, Miller N, Sibthorpe D, Blackwell JM: Linkage of rheumatoid arthritis to the candidate gene NRAMP1 on 2q35. J Med Genet 33:672-677, 1996
15. Pociot F, Ronningen KS, Bergholdt R, Lorenzen T, Johannesen J, Ye K, Dinarello CA, Nerup J: Genetic susceptibility markers in Danish patients with type I (insulin-dependent) diabetes: evidence for polygenicity in man: Danish Study Group of Diabetes in Childhood. Autoimmunity 19:169-178, 1994
16. Blakemore AIF, Cox A, Gonzalez A-M, Maskill JK, Hughes ME, Wilson RM, Ward JD, Duff GW: Interleukin-1 receptor antagonist allele (ILRN*2) associated with nephropathy in diabetes mellitus. Hum Genet 97:369-374, 1996