Mathematical modelling of insect neuropeptide potencies: Are quantitatively predictive models possible?

Insect Biochemistry and Molecular Biology

Volumn 30, Issue 10, 2000, Pages 899-907

  Lee, Michael J ^a   De Jong, Sijmen ^a   Gäde, Gerd ^b   Poulos, Constantine ^c   Goldsworthy, Graham J ^d  

^a UNILEVER RESEARCH VLAARDINGEN   (Netherlands)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

^c UNIVERSITY OF PATRAS   (Greece)

^d UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Acetate uptake; Adipokinetic hormone; AKH; Lipid mobilisation; QSAR; Structure activity

Indexed keywords

ADIPOKINETIC HORMONE; INSECT HORMONE; NEUROPEPTIDE; OLIGOPEPTIDE;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BIOLOGICAL MODEL; GRASSHOPPER; LIPID TRANSPORT; LOCUST; MATHEMATICAL MODEL; MOLECULAR GENETICS; NONHUMAN; QUANTITATIVE ASSAY; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; GRASSHOPPERS; INSECT HORMONES; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; NEUROPEPTIDES; OLIGOPEPTIDES; PYRROLIDONECARBOXYLIC ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033812175     PISSN: 09651748     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0965-1748(00)00078-3     Document Type: Article

References (25)

1. Structure-function studies on neurohormone D: Activity of naturally occurring hormone analogs
2. Elimination of uninformative variables for multivariate calibration
3. The molecular conformations of representative arthropod adipokinetic peptides determined by circular dichroism spectroscopy
4. SIMPLS: An alternative approach to partial least squares regression
5. Structure-activity-relationships for the lipid-mobilizing action of further bioanalogs of the adipokinetic hormone red pigment-concentrating hormone family of peptides
6. Sequences of recently identified adipokinetic peptides: What do they tell us with respect to their hyperlipaemic activity in migratory locusts?
7. Potencies of naturally occurring AKH/RPCH peptides in Locusta migratoria in the acetate uptake assay in vitro and comparison with their potencies in the lipid mobilisation assay in vivo
8. Adipokinetic hormones: Interassay variations in potencies as clues to hormone-receptor interactions in locusts
9. Structures, assays and receptors for locust adipokinetic hormones
10. Peptide quantitative structure-activity relationships, a multivariate approach
11. Multivariate parameterisation of 55 coded and non-coded amino acids
12. Acetate uptake assay; the basis of a rapid method for determining potencies of adipokinetic peptides for structure-activity studies
13. The preparation and use of dispersed cells from fat body of Locusta migratoria in a filtration plate assay for adipokinetic peptides
14. Modified adipokinetic peptides containing two tryptophan residues and their activities in vitro and in vivo in Locusta
15. New perspectives on the structures, assays and actions of locust adipokinetic hormones
16. N-terminal modifications to AKH-I from Locusta migratoria and their effects on activity
17. Synthesis and biological activity of adipokinetic hormone analogues modified at the C-terminus
18. Locusta-AKH-III and other peptides containing two tryptophan residues have unusual CD spectra
19. Hypertrehalosaemic insect peptide periplanetin CC-2 and its analogues: Synthesis and biological evaluation
20. A quantitative structure-activity study of some substance P-related peptides
21. Locust adipokinetic hormones: Carrier-independent transport and differential inactivation at physiological concentrations during rest and flight
22. Synthesis and biological activity of locust AKH-I and its analogues with modifications at the threonine residues
23. New chemical descriptors relevant for the design of biologically active peptides. A multivariate characterization of 87 amino acids
24. The effect of analogues of adipokinetic hormone II on second messenger systems in the fat body of Schistocerca gregaria
25. Analogs of Manduca adipokinetic hormone tested in a bioassay and in a receptor-binding assay