Modified adipokinetic peptides containing two tryptophan residues and their activities in vitro and in vivo in Locusta

Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology

Volumn 166, Issue 1, 1996, Pages 61-67

  Lee, M J ^a   Goldsworthy, G J ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Adipokinetic hormone; Fatty acid synthesis; Lipid mobilization; Locust a migratoria; Structure activity

Indexed keywords

ACETIC ACID DERIVATIVE; ADIPOKINETIC HORMONE; DRUG DERIVATIVE; INSECT HORMONE; OLIGOPEPTIDE; PEPTIDE; PYROGLUTAMIC ACID; TRYPTOPHAN;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; CHEMISTRY; GRASSHOPPER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; LIPID METABOLISM; METABOLISM; MOLECULAR GENETICS; STRUCTURE ACTIVITY RELATION;

ACETATES; AMINO ACID SEQUENCE; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GRASSHOPPERS; INSECT HORMONES; LIPID METABOLISM; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PEPTIDES; PYRROLIDONECARBOXYLIC ACID; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPTOPHAN;

EID: 0030066504     PISSN: 01741578     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00264640     Document Type: Article

References (34)

1. Baumann E, Penzlin H (1987) Inactivation of neurohormone D by Malpighian tubules in an insect Peripluneta americana. J Comp Physiol B 157: 511-517
2. Baumann E, Gäde G, Penzlin H (1990) Structure-function studies on neurohormone D: activity of naturally-occurring hormone analogues. J Comp Physiol B 160: 423-429
3. Carlisle JA, Loughton BG (1979) Adipokinetic hormone inhibits protein synthesis in Locusta. Nature 282: 420-421
4. Cusinato O. Wheeler CH, Goldsworthy GJ (1991) The identity and physiological actions of an adipokinetic hormone in Acheta domesticux. J Insect Physiol 37: 461-469
5. Gäde G (1992) Structure-activity relationship for the carbohydratemobilizing action of further bioanalogues of the adipokinetic hormone/red pigment hormone family of peptides. J Insect Physiol 38: 259-266
6. Gäde G (1993) Structure-activity relationships for the lipidmobilizing action of further bioanalogues of the adipokinetic hormone/red pigment-concentrating hormone family of peptides. J Insect Physiol 39: 375-383
7. Gäde G, Goldsworthy GJ, Schaffer MH, Cook JC, Rinehart KL (1986) Sequence analyses of adipokinetic hormones II from corpora cardiaca of Schistocerca nitans, Schistocerca gregaria and Locusta migratoria by fast atom bombardment mass spectrometry. Biochem Biophys Res Comm 134: 723-730
8. Gäde G, Reynolds SE, Beeching JR (1994) Molecular evolution of peptides of the AKH-RPCH family. In: Davy et al (eds) Perspectives in endocrinology. Proc XII Int Congr Comp Endocrinol, Toronto, Ontario, 1993. National Research Council of Canada, Ottawa, pp 119-128
9. Gaus G, Kleinholtz LH, Kegel G, Keller R (1990) Isolation and characterization of red pigment-concentrating hormone (RPCH) from six crustacean species. J Comp Physiol B 160: 373-379
10. Gokuldas M, Hunt PA, Candy DJ (1988) The inhibition of lipid synthesis in vitro in the locust Schistocerca gregaria by factors from the corpora cardiaca. Physiol Entomol 13: 43-48
11. Goldsworthy GJ (1983) The endocrine control of flight metabolism in locusts. Adv Insect Physiol 17: 149-204
12. Goldsworthy GJ (1994) The adipokinetic hormones of insects: are they the insect glucagons? In: Davy et al (eds) Perspectives in endocrinology. Proc XII Int Congr Comp Endocrinol, Toronto, Ontario, 1993. National Research Council of Canada, Ottawa, pp 486-492
13. Goldsworthy G, Lee MJ, Luswata R (1995) Adipokinetic hormones: interassay variations in potencies as clues to hormone-receptor interactions in the locust. In: Konopinska D (ed) Insects. Chemical, physiological and environmental aspects 1994. University of Wroclaw, Poland, pp 17-27
14. Goldsworthy GJ, Mallison K, Wheeler CH (1986a) The relative potencies of two known locust adipokinetic hormones. J Insect Physiol 32: 95-101
15. Goldsworthy GJ, Mallison K, Wheeler CH, Gäde G (1986b) Relative adipokinetic activities of members of the adipokinetic hormone/red pigment concentrating hormone family. J Insect Physiol 32: 433-438
16. Hayes TK, Keeley LL (1990) Structure-activity relationships on hyperglycaemia by representatives of the adipokinetic/hyperglycemic hormone family in Blaberus discoidalis cockroaches. J Comp Physiol B 160: 187-194
17. Isaac RE (1988) Neuropeptide-degrading endopeptidase activity of locust (Schistocerea gregaria) synaptic membranes. Biochem J 225: 843-847
18. Kodrik D, Goldsworthy GJ (1995) Inhibition of RNA synthesis by adipokinetic hormones and brain factor(s) in adult fat body of Locusta migratoria. J Insect Physiol 41: 127-133
19. Lee MJ, Goldsworthy GJ (1995a) Acetate uptake assay; the basis of a rapid method for determining potencies of adipokinetic peptides for structure-activity studies. J Insect Physiol 41: 163-170
20. Lee MJ, Goldsworthy GJ (1995b) The preparation and use of dispersed cells from fat body of Locusta migratoria in a filtration plate assay for adipokinetic peptides. Anal Biochem 228: 155-161
21. Mwangi RW, Goldsworthy GJ (1977) Age-related changes on the response to adipokinetic hormone in Locusta. Physiol Entomol 2: 37-42
22. Oudejans RCH, Kooiman FP, Heerma W, Versluis C. Slotboom AJ, Beenakkers AMT (1991) Isolation and structure elucidation of a novel adipokinetic hormone (Lom-AKH-III) from the glandular lobes of the corpus cardiacum of the migratory locust Locust a migratoria. Eur J Biochem 195: 351-359
23. Oudejans RCHM, Dijkhuizen RM, Kooiman FP, Beenakkers AMTh (1992) Dose-response relationships of adipokinetic hormones (Lom-AKH-I II and III) from the migratory locust Locust a migratoria. Proc Exp Appl Entomol 3: 165-166
24. Raina AK, Gäde G (1988) Insect peptide nomenclature. Insect Biochem 8: 785-787
25. Rayne RC, O'Shea M (1992) Inactivation of neuropeptide hormones (AKH I and AKH II) studied in vivo and in vitro. Insect Biochem Mol Biol 22: 25-34
26. Siegert KJ, Mordue W (1992) Degradation of adipokinetic hormones. Insect Biochem Molec Biol 22: 657-663
27. Siegert KJ, Morgan PJ, Mordue W (1985) Primary structures of locust adipokinetic hormone II. Biol Chem Hoppe-Seyler 366: 713-727
28. Stone JV, Mordue W, Batley KE, Morris HR (1976) Structure of locust adipokinetic hormone, a neurohormone that regulates lipid utilization during flight. Nature 263: 207-211
29. Stone JV, Mordue W, Broomfield CE, Hardy PM (1978) Structure-activity relationships for the lipid mobilizing action of adipokinetic hormone. Synthesis and activity of a series of ormone analogues. Eur J Biochem 89: 195-202
30. Van Marrewijk WJA, Van Den Broek AThM, Beenakkers AMTh (1980) Regulation of gluconeogenesis in the fat body during flight. Insect Biochem 10: 675-679
31. Van Marrewijk WJA, Van Den Broek AThM, Beenakkers AMTh (1986) Hormonal control of fat body glycogen mobilization for locust flight. Gen Comp Endocrinol 64: 136-142
32. s and cAMP. Mol Cell Endocrinol 107: 165-171
33. 2+ to potentiate cAMP-induced activation of glycogen phosphorylase. Cell Calcium 17: 459-467
34. Ziegler R, Eckart K, Jasensky RD, Law JH (1991) Structure-activity studies on adipokinetic hormones in Manduca sexta. Archs Insect Biochem Physiol 18: 229-237