The molecular conformations of representative arthropod adipokinetic peptides determined by circular dichroism spectroscopy

Insect Biochemistry and Molecular Biology

Volumn 28, Issue 1, 1998, Pages 43-50

  Cusinato, Ornella ^a   Drake, Alex F ^b   Gäde, Gerd ^c   Goldsworthy, Graham J ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

turn; Adipokinetic hormones; Circular dichroism; Extended conformation; Lipid mobilization

Indexed keywords

NEUROPEPTIDE;

ARTHROPOD; ARTICLE; CIRCULAR DICHROISM; LIPID METABOLISM; MICELLE; NONHUMAN; PROTEIN CONFORMATION;

EID: 0031971104     PISSN: 09651748     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0965-1748(97)00094-5     Document Type: Article

References (30)

1. Chou P. Y., Fasman G. D. Beta turns in proteins. J. Mol. Biol. 115:1977;135-175.
2. Cusinato O., Wheeler C. H. and Goldsworthy G. J. (1991) The identity and physiological actions of an adipokinetic hormone in Acheta domesticus. J. Insect Physiol. 37, 461-469.
3. Drake A. F., Hider R. C. The structure of melittin in lipid bilayer membranes. Biochim. Biophys. Acta. 555:1979;371-373.
4. Drake A. F., Hider R. C., Tamiya N. Analysis of the 225-230 nm Circular Dichroism Band of Elapid Toxins. Biopolymers. 27:1987;113-122.
5. Drake A. F., Siligardi G., Gibbons W. A. Reassessment of the electronic circular dichroism criteria for random coil conformations of poly-L-lysine and the implications for protein folding and denaturation studies. Biophys. Chem. 31:1988;143-146.
6. Gäde G. Structure-function studies on hypertrehalosaemic and adipokinetic hormones: activity of naturally-occurring analogues and some N- and C- terminal modified analogues. Physiol. Entomol. 15:1990;299-316.
7. Gäde, G., Reynolds, S. E. and Beeching, J. R. (1994). Molecular evolution of peptides of the AKH-RPCH family. In Perspectives in Comparative Endocrinology, eds Davey K. G., Peter R. E and Tobe S. S., pp. 119-128. National Research Council of Canada, Ottawa.
8. Gäde G., Goldsworthy G. J., Schaffer M. H., Cook J. C., Rinehart K. L. Jr. Sequence analyses of adipokinetic hormones II from corpora cardiaca of Schistocerca nitans, Schistocerca gregaria and Locusta migratoria by fast atom bombardment mass spectrometry. Biochem. Biophys. Res. Commun. 134:1986;723-730.
9. Goldsworthy G. J. The endocrine control of flight metabolism in locusts. Adv. Insect Physiol. 17:1983;149-204.
10. Goldsworthy, G. J. (1990). Hormonal control of flight metabolism in locusts. In Biology of grasshoppers, eds. Chapman R. F. and Joern A., pp. 205-226. J. Wiley and Sons, New York.
11. Goldsworthy G. J., Mallison K., Wheeler C. H. The relative potencies of two known locust adipokinetic hormones. J. Insect Physiol. 32:1986;95-101.
12. Goldsworthy G. J., Mallison K., Wheeler C. H., Gäde G. Relative adipokinetic activities of members of the adipokinetic hormone/red pigment concentrating hormone family. J. Insect Physiol. 32:1986;433-438.
13. Goldsworthy, G. J., Wheeler, C. H., Cusinato, O. and Wilmot, C. M. (1990). Adipokinetic hormones, structures and functions. In Progress in Comparative Endocrinology, eds. Epple A., Scanes C. G. and Stetson M. H., pp. 28-34. Alan R. Liss. Inc, New York.
14. Goldsworthy, G. J., Coast, G. M., Wheeler, C. H., Cusinato, O., Kay, I. and Khambay, B. (1992). The structure and functional activity of neuropeptides. In Insect Molecular Science, eds. Crampton J. M. and Eggleston P., pp. 205-225. Academic Press, London and San Diego.
15. Greenfield N., Fasman G. D. Computed circular dichroism spectra for the evaluation of protein conformation. Biochem. 8:1969;4108-4116.
16. Jutsum A. R., Goldsworthy G. J. Some effects of mermithid infection on metabolic reserves and flight in Locusta. International Journal of Parasitology. 4:1974;625-630.
17. Lee M. J., Goldsworthy G. J. Acetate uptake test; the basis of a rapid method for determining potencies of adipokinetic peptides for structure-activity studies. J. Insect Physiol. 41:1995;163-170.
18. Lee M. J., Cusinato O., Luswata R., Wheeler C. H., Goldsworthy G. J. N-terminal modifications to AKH-I from Locusta migratoria: assessment of biological potencies in vivo and in vitro. Regul. Peptides. 69:1997;69-76.
19. Lee M. J., Drake A. F., Goldsworthy G. J. Locusta-AKH-III and related peptides containing two tryptophan residues have unusual CD spectra. Biochem. Biophys. Res. Commun. 226:1996;407-412.
20. Lewis P. N., Momany F. A., Scheraga H. A. Chain reversals in proteins. Biochim. Biophys. Acta. 303:1973;211-229.
21. Nachman R. J., Holman G. M., Haddon W. E. Leads for insect neuropeptide mimetic development. Arch. Insect Biochem. Physiol. 22:1993;181-197.
22. Siegert K., Morgan P. J., Mordue W. Primary structures of locust adipokinetic hormones II. Biol. Chem. Hoppe-Seyler. 366:1985;723-727.
23. II conformation for the molecular recognition of peptides. Biopolymers (Peptide Science). 37:1995;281-292.
24. Siligardi G., Drake A. F., Mascagni P., Rowlands D., Brown F., Gibbons W. A. A CD strategy for the study of polypeptide folding/unfolding. Int. J. Pept. Protein Res. 38:1991;519-527.
25. Stone J. V., Mordue W., Broomfield C. E., Hardy P. M. Structure-activity relationships for the lipid-mobilizing action of adipokinetic hormone. Synthesis and activity of a series of hormone analogues. Eur. J. Biochem. 89:1978;195-202.
26. Wilmot C. M., Thornton J. M. Analysis and prediction of the different types of beta turn in proteins. J. Mol. Biol. 203:1988;221-232.
27. Woody R. W. Circular dichroism and conformation of unordered polypeptides. Adv. Biophys. Chem. 2:1991;1-81.
28. Wheeler, C. H., Drake, A. F., Wilmot, C. M., Thornton, J. M. and Goldsworthy, G. J. (1990). Structures in the AKH family of neuropeptides. In Insect Neurochemistry and Neurophysiology, eds. Borkovec A. B. and Gelman D. B., pp. 235-238. Humana Press, Clifton, New Jersey.
29. Ziegler R., Jasensky R. D., Morimoto H. Characterization of the adipokinetic hormone receptor from the fat body of Manduca sexta. Regulatory Peptides. 57:1995;329-338.
30. 3H NMR spectroscopy and molecular mechanics. Biochem. Biophys. Res. Commun. 198:1994;228-235.