Disease association and cytotoxic effects of DNA-hydrolyzing autoantibodies

Chemical Immunology

Volumn 77, Issue , 2000, Pages 130-156

  Gabibov, A G ^a   Kozyr, A V ^a   Kolesnikov, A V ^a  

^a SHEMYAKIN OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CATALYTIC ANTIBODY; DNA ANTIBODY; DOUBLE STRANDED DNA; FAS LIGAND; MONOCLONAL ANTIBODY; SINGLE STRANDED DNA; TUMOR NECROSIS FACTOR ALPHA;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANTIGEN ANTIBODY REACTION; ARTICLE; AUTOIMMUNE DISEASE; BINDING AFFINITY; CATALYSIS; CATALYST; CYTOTOXICITY; DISEASE ASSOCIATION; DNA BINDING; DNA PROTEIN COMPLEX; HUMAN; LUPUS ERYTHEMATOSUS; LYMPHOPROLIFERATIVE DISEASE; MULTIPLE MYELOMA; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS;

EID: 0033811092     PISSN: 10150145     EISSN: None     Source Type: Journal    
DOI: 10.1159/000058797     Document Type: Article

References (105)

1. Catalytic antibodies
2. Catalytic hydrolysis of vasoactive intestinal peptide by human autoantibody
3. Molecular mechanisms of CD8 + T cell-mediated delayed hypersensitivity: Implications for allergies, asthma, and autoimmunity
4. Catalytic activity of anti-thyroglobulin antibodies
5. DNA hydrolyzing autoantibodies
6. Characterization and selectivity of catalytic antibodies from human scrum with RNase activity
7. DNA hydrolysis by monoclonal anti-ssDNA autoantibody BV 04-01: Origins of catalytic activity
8. Anti-idiotypic and natural catalytically active antibodies
9. Monoclonal anti-idiotypic antibodies as functional internal images of enzyme active sites: Production of a catalytic antibody with a cholinesterase activity
10. Unexpectedly high occurrence of catalytic antibodies in MRL/lpr and SJL mice immunized with a transition-state analog: Is there a linkage to autoimmunity?
11. Endoproteinase-protein inhibitor interactions
12. Pathogenic anti-DNA antibodies in SLE: Idiotypic families and genetic origins
13. Complement activation by antibodies to DNA in systemic lupus erythematosus measured by enzyme immunoassay
14. Anti-(DNA-histone) antibodies in active lupus nephritis
15. Broken dogma: Penetration of autoantibodies into living cells
16. Cellular dysfunction induced by penetration of autoantibodies into living cells: Cellular damage and dysfunction mediated by antibodies to dsDNA and ribosomal P proteins
17. Autoantibodies to ribosomal P proteins penetrate into live hepatocytes and cause cellular dysfunction in culture
18. Human monoclonal anti-DNA antibodies react as lymphocytotoxic antibodies
19. Natural hidden antibodies reacting with DNA or cardiolipin bind to thymocytes and evoke their death
20. Polyclonal IgG anti-dsDNA antibodies exert cytotoxic effect on cultured rat mesangial cells by binding to cell membrane and augmenting apoptosis
21. Effect of anti-DNA autoantibodies on the gene expression of interleukin 8, transforming growth factor-beta, and nitric oxide synthase in cultured endothelial cells
22. DNA-protein complexes. Natural targets for DNA-hydrolyzing antibodies
23. Cleavage of supercoiled plasmid DNA by autoantibody Fab fragment: Application of the flow linear dichroism technique
24. A novel method for purification of catalytic antibodies toward DNA from sera of patients with lymphoproliferative diseases
25. Superhelical DNA with local substructures. A generalization of the topological constraint in terms of the intersection number and the ladder-like correspondence surface
26. DNA-hydrolyzing autoantibodies
27. Interaction of DNA-hydrolyzing autoantibodies with low molecular weight substrates
28. DNA-hydrolyzing activity of the light chain of IgG antibodies from milk of healthy human mothers
29. Proteolytic activity of an antibody light chain
30. DNA-hydrolyzing activity of Bence Jones proteins
31. Study of the interaction of DNA-hydrolyzing autoantibodies from serum of patients with lymphoproliferative disorders with oligodeoxyribonucleotides using an affinity sorption method
32. An autoantibody to single-stranded DNA: Comparison of the three-dimensional structures of the unliganded Fab and a deoxynucleotide-Fab complex
33. X-ray structure of the DNase I-d(GGTATACC) complex at 2.3 A resolution
34. Cocrystal structure of an editing complex of Klenow fragment with DNA
35. Structure of ribonuclease H phased at 2.0 A resolution by MAD analysis of the selemomethionil protein
36. Creation of a ribonuclease abzyme through site-directed mutagenesis
37. Preparation, characterization and crystallization of an antibody fab fragment that recognizes RNA
38. Construction, characterization, and selected site-specific mutagenesis of an anti-single-stranded DNA single-chain autoantibody
39. Elucidation of anti-ssDNA BV04-01 binding interaction with homooligonucleotides
40. Evidence for induced fit in antibody-DNA complexes
41. Clinical significance of antinuclear antibodies in systemic rheumatic diseases
42. Autoantibodies typical of non-organ-specific autoimmune diseases in HIV-seropositive patients
43. Novel functional activities of anti-DNA autoantibodies from sera of patients with lymphoproliferative and autoimmune diseases
44. Autoimmune diseases and monoclonal gammopathies
45. Increased natural antibody activity in sera of patients with malignant non-Hodgkin's lymphomas containing paraproteins
46. Basic biology of autoimmune phenomena in chronic lymphocytic leukemia
47. Development of human antibody variable genes in systemic autoimmunity
48. Antibodies to DNA
49. Anti-histone reactivity in systemic lupus erythematosus sera: A disease activity index linked to the presence of DNA:anti-DNA immune complexes
50. Nucleosome: A major immunogen for pathogenic autoantibody-inducing T cells of lupus
51. An unexpectedly efficient catalytic antibody operating by ping-pong and induced fit mechanisms
52. DNA-specific antiidiotypic antibodies in the sera of patients with autoimmune diseases
53. Functional mimicry: Elicitation of a monoclonal anti-idiotypic antibody hydrolizing beta-lactams
54. Anti-DNA antibodies bind to DNase I
55. Receptor-mediated cellular entry of nuclear localizing anti-DNA antibodies via myosin 1
56. Antibodies to a soluble form of a tumor necrosis factor (TNF) receptor have TNF-like activity
57. Selective apoptosis of CD4 + CD8 + thymocytes by the anti-Fas antibody
58. Therapeutic preparations of normal polyspecific IgG (IVIg) induce apoptosis in human lymphocytes and monocytes: A novel mechanism of action of IVIg involving the Fas apoptotic pathway
59. Cross-reaction of anti-DNA autoantibodies with cell surface proteins
60. A monoclonal anti-double-stranded DNA autoantibody binds to a 94-kDa cell-surface protein on various cell types via nucleosomes or a DNA-histone complex
61. A novel class of antitumor antibodies: Nucleosome-restricted antinuclear antibodies (ANA) from healthy aged nonautoimmune mice
62. Nucleosome-releasing treatment makes surviving tumor cells better targets for nucleosome-specific anticancer antibodies
63. Apoptosis and expression of soluble Fas mRNA in systemic lupus erythematosus
64. Murine and human antibodies to native DNA that cross-react with the A and D SnRNP polypeptides cause direct injury of cultured kidney cells
65. Autoantibodies to nuclear antigens: Correlation between cytotoxicity and DNA-hydrolyzing activity
66. Autoantibodies to T and B cell lines detected in serum samples from patients with systemic lupus erythematosus with lymphopenia and hypocomplementaemia
67. Cross-reactivity of murine monoclonal anti-DNA antibodies with human and murine skin: A possible pathogenetic role in skin lesions of lupus erythematosus
68. Cross-reactivity distinguishes serum and nephritogenic anti-DNA antibodies in human lupus from their natural counterparts in normal serum
69. Binding of anti-DNA antibodies and inhibition of glomerulonephritis in MRL-lpr/lpr mice by heparin
70. Reaction patterns of monoclonal antibodies to DNA
71. Cloning and sequence analysis of the VH and VL regions of an anti-myelin/DNA antibody from a patient with peripheral neuropathy and chronic lymphocytic leukemia
72. Characterization of autoantibody activities in sera anti-DNA antibody and circulating immune complexes from 12 systemic lupus erythematosus patients
73. Toward an understanding of the molecular mechanisms of physiological cell death
74. Dual signaling of the Fas receptor: Initiation of both apoptotic and necrotic cell death pathways
75. Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis
76. Different regulation of c-Myc- and E2F-1-induced apoptosis during the ongoing cell cycle
77. Caspases: The proteases of the apoptotic pathway
78. Differential involvement of caspases in apoptosis of myeloid leukemic cells induced by chemotherapy versus growth factor withdrawal
79. Lipopolysaccharide activates caspase-1 (interleukin-1-converting enzyme) in cultured monocytic and endothelial cells
80. Interferon gamma induces upregulation and activation of caspases 1, 3, and 8 to produce apoptosis in human erythroid progenitor cells
81. Caspase 1-related protease inhibition retards the execution of okadaic acid- and camptothecin-induced apoptosis and PAI-2 cleavage, but not commitment to cell death in HL-60 cells
82. Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis
83. Apoptosis: A different type of cell death
84. Polyreactive anti-DNA monoclonal antibodies and a derived peptide as vectors for the intracytoplasmic and intranuclear translocation of macromolecules
85. Molecular and structural analysis of nuclear localizing anti-DNA lupus antibodies
86. Mechanisms of cellular penetration and nuclear localization of an anti-double strand DNA autoantibody
87. Nuclear protein import
88. Genetic and structural evidence for antigen selection of anti-DNA antibodies
89. Vesicle budding on Golgi membranes: Regulation by G proteins and myosin motors
90. Antibody penetration of viable human cells. II. Anti-RNP antibodies binding to RNP antigen expressed on cell surface, which may mediate the antibody internalization
91. Immunochemical, structural and translocating properties of anti-DNA antibodies from (NZB x NZW)F1 mice
92. Efficient gene delivery by a peptide derived from a monoclonal anti-DNA antibody
93. Targeted gene delivery to mammalian cells by filamentous bacteriophage
94. The penetration of autoantibodies into cells may induce tolerance to self by apoptosis of autoreactive lymphocytes and cause autoimmune disease by dysregulation and/or cell damage
95. Penetrating anti-DNA monoclonal antibodies induce activation of human peripheral blood mononuclear cells
96. Penetration of anti-DNA antibodies into immature live cells
97. Nuclear changes in apoptosis
98. Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis
99. p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes
100. Darzynkiewicz: G1 arrest of U937 cells by onconase is associated with suppression of cyclin D3 expression, induction of p16(INK4A), p21(WAFI/CIPI) and decreased pRb phosphorylation
101. Ribonuclease A variants with potent cytotoxic activity