P2-receptor agonists: From molecular recognition studies to potential clinical applications

Drug Development Research

Volumn 50, Issue 3-4, 2000, Pages 338-354

  Fischer, Bilha ^a  

^a BAR ILAN UNIVERSITY   (Israel)

Author keywords

ATP analogues; Cardiac activity; Insulin secretagogues; Molecular recognition; P2 receptors

Indexed keywords

ADENOSINE TRIPHOSPHATE DERIVATIVE; CALCIUM ION; INSULIN; PURINE P2 RECEPTOR; XANTHINE DERIVATIVE;

CONFORMATION; ENZYME ACTIVITY; ENZYME METABOLISM; HEART CONTRACTION; HEART DISEASE; HYDROLYSIS; MOLECULAR RECOGNITION; REVIEW;

EID: 0033809560     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/1098-2299(200007/08)50:3/4<338::AID-DDR17>3.0.CO;2-1     Document Type: Review

References (70)

1. Purinoceptors: Are there families of P2X and P2Y purinoceptors?
2. Purinergic signaling: Pathophysiological roles
3. The G-protein coupled receptors for ATP and other nucleotides: A new receptor family
4. Nucleotide receptors in the nervous system: An abundant component using diverse transduction mechanisms
5. 2-purinoceptors on β cell and pancreatic vascular bed
6. 2 purinoceptors mediating insulin secretion from perfused rat pancreas
7. P2 purine and pyrimidine receptors: Emerging superfamilies of G-protein and ligand-gated ion channels receptors
8. The regulation of vascular function by P2 receptors: Multiple site and multiple receptors
9. Characterisation of subtypes of the P2X and P2Y families of ATP receptors in the foetal human heart
10. 2-Thioether derivatives of adenine nucleotides are exceptionally potent agonists at adenylyl cyclase-linked P2Y-purinoceptors
11. Effects of phosphorothioate analogues of ATP, ADP and AMP on guinea-pig taenia coli and urinary bladder
12. Structure activity relationship for derivatives of adenosine 5'-triphosphate as agonists at P2-purinoceptors: Heterogeneity within P2X and P2Y subtypes
13. 1-receptors
14. Potential functional roles of extracellular ATP in kidney and urinary tract
15. Effects of phosphate-modified adenine nucleotide analogues on insulin secretion from perfused rat pancreas
16. Purification and properties of human placental ATP diphosphohydrolase
17. Cloning and functional expression of a human uridine nucleotide receptor
18. 6 receptor
19. 2+ responses
20. NF279: A novel potent and selective antagonist of P2X-receptor mediated responses
21. Site directed mutagenesis of P2U purinoceptors
22. P2X receptors
23. Identification of potent, selective P2Y-purinoceptor agonists: Structure-activity relationships for 2-thioether derivatives of adenosine 5'-triphosphate
24. Therapeutic applications of ATP-(P2)-receptors agonists and antagonists
25. 2-Thioether-5'-O-(1-thiotriphosphate) adenine derivatives as new insulin secretagogues acting through P2Y-receptors
26. Characterization of 'mini-nucleotides' as P2X-receptor agonists in rat cardiocytes culture: An integrated synthetic, biochemical and theoretical study
27. Synthesis, mechanism and fluorescence properties of 8-(aryl)-3-β-D-ribofuranosylimidazo[2,1-i]purine 5'-phosphate derivatives
28. Novel nucleosides triphosphate diphosphohydrolase inhibitors: Synthesis, biochemical and pharmacological characterization
29. 1-receptor. I. A synthetic, biochemical, and NMR approach
30. P2-purinergic receptors-subtype-associated signalling responses and structure
31. Pharmacological selectivities of molecularly defined subtypes of P2Y receptors
32. Stimulation of insulin secretion and improvement of glucose tolerance in rat and dog by the P(2y) purinoceptor agonist, adenosine-5'-O-(2-thiodiphosphate)
33. 1 receptor in surface expression and activation processes
34. The function of ATP receptors in the hippocampus
35. 1 receptors
36. Molecular recognition in P2 receptors: Ligand development aided by molecular modeling and mutagenesis
37. Peptidyl conjugates of adenosine 5'-carboxylic acid synthesized and evaluated as ligands for P2 purinoceptors
38. 1-receptor
39. How should P2X purinoceptors be classified pharmacologically
40. Design and Pharmacological characterization of selective P2-purinoceptor antagonists
41. Characterization and purification of a calcium-sensitive ATP diphosphohydrolase from pig pancreas
42. Signal transduction pathways coupled to a P2U receptor in neuroblastoma X glioma (NG 108-115) cells
43. Structural specificity of nucleotides for insulin secretory action from the isolated perfused rat pancreas
44. 2 purinoceptor agonists: New insulin secretagogues potentially useful in the treatment of non-insulin-dependent diabetes mellitus
45. 1-receptor. II. A computational approach
46. 1-receptor: Molecular modeling and site-directed mutagenesis as tools to identify agonist and antagonist recognition sites
47. 1 receptor
48. Molecular cloning and characterization of a novel orphan receptor (P(2p)) expressed in human pancreas that shows high structural homology to the P2U purinoceptor
49. Identification and cloning of a human P2U purinoceptor a target for cystic fybrosis pharmacotherapy
50. Metabolism of adenine nucleotides by ectoenzymes of vasculare endothelial and smooth-muscle cells in culture
51. Evidence for two different types of P2 receptors stimulating insulin secretion from pancreatic B cell
52. Purinergic receptors and metabolic function
53. Hydrolysis of P2-purinoceptor agonists by a purified ectonucleotidase from the bovine aorta, the ATP diphosphohydrolase
54. Effects of 2-methylthio ATP on insulin secretion in the dog in vivo
55. Purification of pancreas Type I ATP diphosphohydrolase and identification by affinity labelling with 5'-p-fluorosulfonyl benzoyl adenosine ATP analogue
56. Adenosine and adenosine receptors in the cardiovascular system: Biochemistry, physiology and pharmacology
57. 2 purinoceptor and synthesis of selected ligands
58. Developments in purine and pyrimidine receptors based therapeutics
59. Modelling the P2Y purinoceptor using rhodopsin as template
60. 3, and heteromeric PX(2/3) receptors
61. Ecto-nucleotidases terminate purinergic signalling in the cochlear endolymphatic compartment
62. 3) activated preferentially by nucleoside diphosphates
63. Molecular biology of P2Y purinoceptors: Expression in rat heart
64. The structure-activity relationships of ectonucleotidases and of excitatory P2-purinoceptors: Evidence that the dephosphorylation of ATP analogues reduces pharmacological potency
65. Ecto-enzymes and metabolism of extracellular ATP
66. Signalling via ATP in the nervous system
67. Synthesis and biological activity of novel 2-thio derivatives of ATP