Synthesis and antiproliferative activity of tyrphostins containing quinoline moieties

Anti-Cancer Drug Design

Volumn 11, Issue 6, 1996, Pages 463-483

  Brunton, Valerie G ^a   Lear, Martin J ^a   McKeown, Paul ^a   Robins, David J ^a   Workman, Paul ^a,b  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Antiproliferative activity; Knoevenagel reaction; Protein tyrosine kinases; Tyrphostins

Indexed keywords

ENZYME INHIBITOR; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; QUINOLONE DERIVATIVE; TYRPHOSTIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOPHOSPHORYLATION; CANCER CELL CULTURE; CANCER INHIBITION; CANCER RESISTANCE; CELL PROLIFERATION; CENTRAL NERVOUS SYSTEM DISEASE; COLON CANCER; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME INHIBITION; FIBROBLAST; HUMAN; HUMAN CELL; KIDNEY CANCER; LUNG NON SMALL CELL CANCER; MELANOMA; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REACTION ANALYSIS; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

ADENOCARCINOMA; BENZYLIDENE COMPOUNDS; BREAST NEOPLASMS; CARCINOMA, SQUAMOUS CELL; CELL DIVISION; CELL LINE; FEMALE; FIBROBLASTS; HUMANS; MALE; NEOPLASMS; NITRILES; OXIDATION-REDUCTION; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; QUINOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0029778978     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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