Synthesis and biological evaluation of a series of tyrphostins containing nitrothiophene moieties as possible epidermal growth factor receptor tyrosine kinase inhibitors

Anti-Cancer Drug Design

Volumn 11, Issue 4, 1996, Pages 265-295

  Brunton, Valerie G ^a,c   Kelland, Lloyd R ^b   Lear, Martin J ^a   Montgomery, Gerard J ^a   Robertson, Jane H ^a   Robins, David J ^a   Queen, Julian ^a   Workman, Paul ^a,d  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^c BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^d ASTRAZENECA   (United Kingdom)

Author keywords

EGF receptor; Tyrosine kinase inhibitors

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE; THIOPHENE DERIVATIVE; TYRPHOSTIN;

ARTICLE; BREAST CANCER; CELL FREE SYSTEM; COLON CANCER; CYTOTOXICITY; DNA DAMAGE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LUNG NON SMALL CELL CANCER; MELANOMA; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL DIVISION; CELL-FREE SYSTEM; CELLS, CULTURED; DNA DAMAGE; ENZYME INHIBITORS; HUMANS; NITRILES; PHOSPHORYLATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; SPECTRUM ANALYSIS; THIOPHENES; TUMOR CELLS, CULTURED;

EID: 0029901883     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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