Topoisomerase I inhibition and cytotoxicity of 5-bromo- and 5-phenylterbenzimidazoles

Bioorganic and Medicinal Chemistry

Volumn 8, Issue 11, 2000, Pages 2591-2600

  Rangarajan, Meera ^a   Kim, Jung Sun ^a   Sim, Sai Peng ^b   Liu, Angela ^b   Liu, Leroy F ^b,c   LaVoie, Edmond J ^a,c  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2'' CHLORO 5,6 DIBROMOTERBENZIMIDAZOLE; 2'' TRIFLUOROMETHYL 5,6 DIBROMOTERBENZIMIDAZOLE; 5 BROMOTERBENZIMIDAZOLE DERIVATIVE; 5 PHENYLTERBENZIMIDAZOLE DERIVATIVE; 5,6 DIBROMOTERBENZIMIDAZOLE; ANTINEOPLASTIC AGENT; BENZIMIDAZOLE DERIVATIVE; DNA TOPOISOMERASE; FUNCTIONAL GROUP; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CYTOTOXICITY; DNA CLEAVAGE; DRUG SYNTHESIS; ENZYME INHIBITION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INTOXICATION; LIPOPHILICITY; LYMPHOBLAST; LYMPHOBLASTOMA; MASS SPECTROMETRY; MITOSIS; NITROBLUE TETRAZOLIUM TEST; PROTON NUCLEAR MAGNETIC RESONANCE; RNA TRANSLATION; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

BENZIMIDAZOLES; DNA TOPOISOMERASES, TYPE I; ENZYME INHIBITORS; HUMAN; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; SPECTRUM ANALYSIS, MASS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED;

EID: 0033807939     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(00)00188-7     Document Type: Article

References (24)