Blood concentration of coenzyme Q10 increases in rats when esterified forms are administered

Journal of Nutrition

Volumn 129, Issue 12, 1999, Pages 2113-2118

  Turunen, Mikael ^a   Appelkvist, Eeva Liisa ^b   Sindelar, Pavel ^b   Dallner, Gustav ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Aging; Blood lipids; Coenzyme Q; Rats

Indexed keywords

UBIDECARENONE;

ACETYLATION; AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DERIVATIZATION; DIET SUPPLEMENTATION; ESTERIFICATION; FAT INTAKE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIPID TRANSPORT; LIVER LEVEL; LIVER MITOCHONDRION; MALE; NONHUMAN; RAT; SPLEEN;

ACETYLATION; ANIMALS; DIETARY SUPPLEMENTS; ESTERIFICATION; LIVER; MALE; RATS; RATS, SPRAGUE-DAWLEY; SPLEEN; SUCCINATES; UBIQUINONE;

EID: 0032698802     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Aberg, F., Appelkvist, E.-L., Dallner, G. & Ernster, L. (1992) Distribution and redox state of ubiquinones in rat and human tissues. Arch. Biochem. Biophys. 295: 230-234.
2. 10 in the rat after intravenous administration by a microsphere delivery system or a new type of solution. Int. J. Tissue React. 10: 99-102.
3. Andrée, P., Dallner, G. & Ernster, L. (1998) Ubiquinol: an endogenous lipid-soluble antioxidant in animal tissues. In: Free Radicals, Oxidative Stress, and Antioxidants (Özben, T., ed.), pp. 293-314. Plenum Press, New York, NY.
4. Beyer, R. E., Burnett, B.-A., Cartwright, K. J., Edington, D. E., Falzon, M. J., Kreitman, K. R., Kuhn, T. W., Ramp, B. J., Rhee, S.Y.S., Rosenwasser, M. J., Stein, M. & Chin-I, A. (1985) Tissue coenzyme Q (ubiquinone) and protein concentrations over the life span of the laboratory rat. Mech. Aging Dev. 32: 267-281.
5. Beyer, R. E., Noble, W. M. & Hirschfeld, T. J. (1962) Coenzyme Q (ubiquinone) levels of tissues of rats during acclimation to cold. Can. J. Biochem. 40: 511-518.
6. Burton, G. W., Ingold, K. U., Foster, D. O., Cheng, S. C., Webb, A., Hughes, L. & Lusztyk, E. (1988) Comparison of free α-tocopherol and α-tocopheryl acetate as sources of vitamin E in rats and humans. Lipids 23: 834-840.
7. 2H NMR investigation of the organization and dynamics of polyisoprenoids in membranes. J. Biol. Chem. 258: 9122-9127.
8. Eggens, I., Elmberger, P. G. & Löw, P. (1989) The lipid composition of highly differentiated human hepatomas, with special reference to fatty acids. Br. J. Exp. Pathol. 70: 83-92.
9. Elmberger, P. G., Kalén, A., Brunk, U. & Dallner, G. (1989) Discharge of newly synthesized dolichol, dolichyl phosphate and ubiquinone with lipoproteins to rat liver perfusate and to the bile. Lipids 24: 919-930.
10. Ericsson, J., Scallen, T. J., Chojnacki, T. & Dallner, G. (1991) Involvement of sterol carrier protein-2 in dolichol biosynthesis. J. Biol. Chem. 266: 10602-10607.
11. Ericsson, J., Thelin, A., Chojnacki, T. & Dallner, G. (1992) Isoprenoid biosynthesis in rat liver peroxisomes. Characterization of cis-prenyltransferase and squalene synthase. J. Biol. Chem. 267: 19730-19735.
12. Ernster, L. (1993) Lipid peroxidation in biological membranes: mechanisms and implications. In: Active Oxygens, Lipid Peroxides, and Antioxidants (Yagi, K., ed.), pp. 1-38. CRC Press, Boca Raton, FL.
13. Ernster, L. & Dallner, G. (1995) Biochemical, physiological and medical aspects of ubiquinone function. Biochim. Biophys. Acta 1271: 195-204.
14. 10. In: Highlights in Ubiquinone Research (Lenaz, G., Barnabei, O., Rabbi, A. & Battino, M., eds.), pp. 309-322. Taylor & Francis, London, UK.
15. Forsmark-Andrée, P., Lee, C. P., Dallner, G. & Ernster, L. (1997) Lipid peroxidation and changes in the ubiquinone content and the respiratory chain enzymes of submitochondrial particles. Free Radic. Biol. Med. 22: 391-400.
16. Frei, B., Kim, M. C. & Ames, B. N. (1990) Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations. Proc. Natl. Acad. Sci. USA 87: 4879-4883.
17. Guan, Z. Z., Söderberg, M., Sindelar, P., Prusiner, S. B., Kristensson, K. & Dallner, G. (1996) Upid composition in scrapie-infected mouse brain. Prion infection increases the levels of dolichol-P and ubiquinone. J. Neurochem. 66: 277-285.
18. Haramaki, N., Stewart, D. B., Aggarwal, S., Ikeda, H., Reznick, A. Z. & Packer, L. (1998) Networking antioxidants in the isolated rat heart are selectively depleted by ischemia-reperfusion. Free Radic. Biol. Med. 25: 329-339.
19. Kahn B., Wilcox, H. G. & Heimberg, M. (1989) Cholesterol is required for secretion of very-low-density lipoprotein by rat liver. Biochem. J. 258: 807-816.
20. Kalén, A., Appelkvist, E.-L. & Dallner, G. (1989) Age-related changes in the lipid compositions of rat and human tissues. Lipids 24: 579-584.
21. 10 in health and disease. In: Highlights in Ubiquinone Research (Lenaz, G., Barnabei, O., Rabbi, A. & Battino, M., eds.), pp. 288-292. Taylor & Francis, London, UK.
22. 10 tissue concentrations and life span of male rats and mice. Biochem. Mol. Biol. Int. 44: 727-737.
23. Mataix, J., Mañas, M., Quies, J., Battino, M., Cassinello, M., Lopez-Frias, M. & Huertas, J. R. (1997) Coenzyme Q content depends upon oxidative stress and dietary fat unsaturation. Mol. Asp. Med. 18: 129-135.
24. 10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. Proc. Natl. Acad. Sci. U.S.A. 95: 8892-8897.
25. Mohr, D. & Stocker, R. (1994) Radical-mediated oxidation of isolated human very-low-density lipoprotein. Arterioscler. Thromb. 14: 1186-1192.
26. Morimoto, H., Imada, I., Watanabe, M. & Nakao, Y. (1969) Ubiquinones and related compounds. Liebigs Ann. Chem. 729: 158-170.
27. 10 (ubiquinone). Clin. Investig. 71: 116-123.
28. Okamoto, K., Matsumoto, M., Watanabe, M., Kawada, M., Imamoto, T. & Imada, I. (1985) Effects of 6-(ω-substituted alkyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinones and related compounds on mitochondrial and reduced nicotinamide adenine dinucleotide oxidase systems. Chem. Pharm. Bull. 33: 3745-3755.
29. Quinn, P. J. & Katsikas, H. (1985) Thermal characteristics of coenzyme Q and its interaction with model membrane systems. In: Coenzyme Q (Lenaz, G., ed.), pp. 107-130. John Wiley & Sons, New York, NY.
30. 10 in the rat following its oral administration. Drug Metab. Dispos. 20: 423-427.
31. Söderberg, M., Edlund, C., Kristensson, K. & Dallner, G. (1990) Lipid compositions in different regions of the human brain during aging. J. Neurochem. 54: 415-423.
32. Stocker, R., Bowry, V. W. & Frei, B. (1991) Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol. Proc. Natl. Acad. Sci. U.S.A. 88: 1646-1650.
33. Tollbom, Ö., Valtersson, C., Chojnacki, T. & Dallner, G. (1988) Esterification of dolichol in rat liver. J. Biol. Chem. 263: 1347-1352.
34. Tribble, D. L., van den Berg, J. J., Motchnik, P. A., Ames, B. N., Lewis, D. M., Chait, A. & Krauss, R. M. (1994) Oxidative susceptibility of low density lipoprotein subfractions is related to their ubiquinol-10 and alpha-tocopherol content. Proc. Natl. Acad. Sci U.S.A. 91: 1183-1187.
35. Trumpower, B. L. (1990) The protonmotive Q cycle. Energy transduction by coupling of proton translocation to electron transfer by the cytochrome bc1 complex. J. Biol. Chem. 265: 11409-11412.
36. Upston, J. M., Neuzil, J., Witting, P. K., Alleva, R. & Stocker, R. (1997) Oxidation of free fatty acids in low density lipoprotein by 15-lipoxygenase stimulates nonenzymic, alpha-tocopherol-mediated peroxidation of cholesteryl esters. J. Biol. Chem. 272: 30067-30074.
37. Valtersson, C., van Duyn, G., Verkleij, A. J., Chojnacki, T., de Kruiff, B. & Dallner, G. (1985) The influence of dolichol, dolichol esters and dolichyl phosphate on phospholipid polymorphism and fluidity in model membranes. J. Biol. Chem. 260: 2742-2751.
38. Zhang, Y., Aberg, F., Appelkvist, E.-L., Dallner, G. & Ernster, L. (1995) Uptake of dietary coenzyme Q supplement is limited in rats. J. Nutr. 125: 446-453.
39. Zhang, Y., Turunen, M. & Appelkvist, E.-L. (1996) Restricted uptake of dietary coenzyme Q is in contrast to the unrestricted uptake of α-tocopherol into rat organs and cells. J. Nutr. 126: 2089-2097.