Possible mediation of quinolinic acid-induced hippocampal damage by reactive oxygen species

Amino Acids

Volumn 19, Issue 1, 2000, Pages 275-281

  Stone, T W ^a   Behan, W M H ^b   MacDonald, M ^a   Darlington, L G ^c  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c EPSOM GENERAL HOSPITAL   (United Kingdom)

Author keywords

Amino acids; Antioxidants; Deprenyl; Excitotoxicity; Free radicals; Kynurenines; Melatonin; Neuroprotection; Neurotoxicity; Quinolinic acid; Reactive oxygen species

Indexed keywords

ANTIOXIDANT; LUZINDOLE; MELATONIN; NIALAMIDE; QUINOLINIC ACID; SELEGILINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; BRAIN INJURY; BRAIN TISSUE; DRUG MECHANISM; HIPPOCAMPUS; LIPID PEROXIDATION; NERVE CELL LESION; NEUROPROTECTION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; REVIEW;

ANIMAL; ANTIOXIDANTS; HIPPOCAMPUS; LIPID PEROXIDATION; NEURONS; QUINOLINIC ACID; RATS; REACTIVE OXYGEN SPECIES; RECEPTORS, N-METHYL-D-ASPARTATE; SUPPORT, NON-U.S. GOV'T;

ANIMALIA; HIPPOCAMPUS HIPPOCAMPUS;

EID: 0033795889     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007260070059     Document Type: Review

References (46)

1. Glutamate neurotoxicity in rat cerebellar granule cells: A major role for xanthine oxidase in oxygen radical formation
2. Lipid peroxidation-induced inhibition of GABA uptake in rat brain synaptosomes: Protection by glucocorticoids
3. Impaired suppressor cell activity due to surface sulphydryl oxidation in rheumatoid arthritis
4. Melatonin protects neurons from singlet oxygen induced apoptosis
5. (-)Deprenyl increases activities of superoxide dismutase and catalase in certain brain regions in old male mice
6. The effect of a long term (6 months) treatment with (-)deprenyl on antioxidant enzyme activities in selective brain regions in old female Fischer 344 rats
7. (-)Deprenyl increases activities of superoxide dismutase (SOD) in striatum of dog brain
8. Melatonin protects primary cultures of rat cortical neurones from NMDA excitotoxicity and hypoxia/reoxygenation
9. Melatonin administration protects CA1 hippocampal neurones after transient forebrain ischemia in rats
10. Ionic dependence of glutamate neurotoxicity
11. Melatonin receptors: Are there multiple subtypes?
12. Melatonin and vitamin E limit nitric oxide-induced lipid peroxidation in rat brain homogenates
13. Neurotoxic effects of quinolinic acid in the mammalian central nervous system
14. Is selegiline neuroprotective in Parkinson's disease?
15. Melatonin protects primary cultures of cerebellar granule neurones from kainate but not from N-methyl-D-aspartate excitotoxicity
16. Versatile melatonin: A pervasive molecule serves various functions in signalling and protection
17. The significance of the metabolism of the neurohormone melatonin - Antioxidative protection and formation of bioactive substances
18. 2+ accumulation in cortical cell culture correlates with subsequent neuronal degeneration
19. Relationship of neurologic status in macaques infected with the simian immunodeficiency virus to cerebrospinal fluid quinolinic acid and kynurenic acid
20. Deprenyl enhances neurite outgrowth in cultured rat spinal ventral horn neurones
21. Potentiation of lipid peroxides by ischemia in rat brain
22. Selegiline enhances survival and neurite outgrowth of MPP(+)-treated dopaminergic neurones
23. Melatonin prevents oxidative stress-induced cell death in hippocampal cells
24. Melatonin reduces kainate-induced lipid-peroxidation in homogenates of different brain regions
25. Gene regulation by oxidative stress
26. L-(-)-desmethylselegiline, a metabolite of selegiline [L-(-)-deprenyl], protects mesencephalic dopamine neurones from excitotoxicity in vitro
27. Effects of α-phenyl-tert-butyl nitrone on neuronal survival and motor function following intrastriatal injections of quinolinate or 3-nitropropionic acid
28. (-)Deprenyl reduces delayed neuronal death of hippocampal pyramidal cells
29. The pharmacology and regional variations of quinolinic acid induced excitation in the rat CNS
30. 4-Hydroxy-2(E)-nonenal inhibits CNS mitochondrial respiration at multiple sites
31. A review of the evidence supporting melatonin's role as an antioxidant
32. Quinolinic acid is a potent lipid peroxidant in rat brain homogenates
33. MK-801, an NMDA receptor antagonist, blocks quinolinic acid- induced lipid peroxidation in rat corpus striatum
34. Quinolinic acid: An endogenous metabolite that produces axon-sparing lesions in rat brain
35. 2-induced lipid peroxidation in rat brain homogenates is greatly reduced by melatonin
36. The effect of quinolinate on rat brain lipid peroxidation is dependent on iron
37. The neuropharmacology of quinolinic acid and kynurenic acids
38. Quinolinic acid: A potent endogenous excitant at amino acid receptors in CNS
39. (-)Deprenyl reduces neuronal apoptosis and facilitates neuronal outgrowth by altering protein synthesis without inhibiting monoamine oxidase
40. Hydroxyl and peroxyl radical trapping by the monoamine-B inhibitors deprenyl and MDL 72,974A: Implications for protection of biological substrates
41. Protective effect of melatonin against hippocampal DNA damage induced by intraperitoneal administration of kainate to rats
42. In vitro ischemia promotes glutamate-mediated free radical generation and intracellular calcium accumulation in hippocampal pyramidal neurones
43. A comparison of excitotoxic lesions of the basal forebrain by kainate, quinolinate, ibotenate, NMDA or quisqualate and the effects on toxicity of 2-amino-5-phosphonovaleric acid and kynurenic acid in the rat
44. Apparent antioxidant effect of 1-deprenyl on hydroxyl radical formation and nigral injury elicited by MPP+ in vivo
45. Regional lipid peroxidation in rat brain in vitro: Possible role of endogenous iron