Induction of tolerance to cardiac allografts

Current Opinion in Cardiology

Volumn 11, Issue 2, 1996, Pages 208-213

  Wood, Kathryn J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; HISTOCOMPATIBILITY ANTIGEN; IMMUNOSUPPRESSIVE AGENT;

DRUG EFFICACY; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; HUMAN; IMMUNOLOGICAL TOLERANCE; NONHUMAN; PRIORITY JOURNAL; QUALITY OF LIFE; REVIEW;

ANIMALS; FORECASTING; GENE THERAPY; GRAFT REJECTION; HEART TRANSPLANTATION; HLA ANTIGENS; HUMANS; IMMUNE TOLERANCE; ISOANTIGENS; TRANSPLANTATION CHIMERA; TRANSPLANTATION IMMUNOLOGY;

EID: 0029881881     PISSN: 02684705     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001573-199603000-00015     Document Type: Review

References (32)

1. Sarris G, Moore K, Schroeder J, Hunt S, Fowler M, Valantine H, Vagelos R, Billingham M, Oyer P, Stinson E, et al.: Cardiac transplantation: the Stanford experience in the cyclosporine era. J Thorac Cardiovasc Surg 1994, 108:240-251.
2. Sayegh M, Fine N, Smith J, Renneke H, Milford E, Tilney N: Immunologic tolerance to renal allografts after bone marrow transplants from the same donors. Ann Intern Med 1991, 114:954.
3. Jacobsen N, Taaning E, Ladefoged J, Kristensen J, Pedersen F: Tolerance to an HLA-B,DR disparate kidney allograft after bone marrow transplantation from the same donor. Lancet 1994, 343:800.
4. Rao A, Thomson A, Shapiro R, Starzl T: Chimerism after whole organ transplantation: its relationship to graft rejection and tolerance induction. Curr Opin Nephrol Hypertens 1994, 3:589-595.
5. Schlitt H, Hindrieser J, Hisanaga M: Patterns of donor-type microchimerism after heart transplantation. Lancet 1994, 343:1469. Documentation of the existence of donor-derived material in the skin and peripheral blood of patients after cardiac transplantation using polymerase chain amplification of donor class II sequences. The data presented show that microchimerism after transplantation is dynamic.
6. Fontes P, Rao A, Demetris A, Zeevi A, Trucco M, Carroll P, Rybka W, Rudbert W, Ricordi C, Dodson F, et al.: Bone marrow augmentation of donor-cell chimerism in kidney, liver, heart, and pancreas islet transplantation. Lancet 1994, 344:151-155. Early follow-up data examining the effect of administering donor bone marrow at the time of transplantation.
7. Thomas J, Verbanac K, Smith J, Kasten-Joly J, Gross U, Rebellato L, Haisch C, Carver F, Thomas F: The facilitating effect of one-DR antigen sharing in renal allograft tolerance induced by donor bone marrow in rhesus monkeys. Transplantation 1995, 59:245-255. The data presented suggest that HLA-DR matching between the organ donor and the recipient may influence the effect of administering donor bone marrow on graft survival.
8. Kawai T, Cosimi A, Colvin R, Powelson J, Eason J, Kozlowski T, Sykes M, Monroy R, Tanaka M, Sachs D: Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys. Transplantation 1995, 59:256-262. Describes a protocol for the induction of tolerance in a primate model by mixed allogeneic chimerism.
9. Sykes M, Sachs DH: Mixed allogeneic chimerism as an approach to transplantation tolerance. Immunol Today 1988, 9:23-27.
10. Starzl TE, Demetris AJ, Murase N, Ildstad S, Ricordi C, Trucco M: Cell migration, chimerism and graft acceptance. Lancet 1992, 339:1579-1582.
11. Starzl T, Demetris A, Murase N, Thomson A, Trucco M, Ricordi C: Donor cell chimerism permitted by immunosuppressive drugs: a new view of organ transplantation. Immunol Today 1993, 14:326-332. A concise report of the concept of microchimerism after organ transplantation.
12. Schlitt H, Hundrieser J, R Inge B, Pichlmayer R: Donor-type microchimerism associated with graft rejection eight years after liver transplantation. N Engl J Med 1994, 330:646-647.
13. Murase N, Starzl T, Tanabe M, Fujisaki S, Miyazawa H, Ye Q, Delaney C, Fung J, Demetris A: Variable chimerism graft-versus-host disease, and tolerance after different kinds of cell and whole organ transplantation from Lewis to Brown Norway rats. Transplantation 1995, 60:158-171. This interesting study compares the ability of different organs to induce tolerance to donor alloantigens after transplantation when survival of the primary grafts is induced by administration of a short course of an immunosuppressive drug, tacrolimus. The data presented show very clearly that all organs are not equivalent in their ability to induce tolerance. The authors try to assess how complete the degree of tolerance induced by the different strategies investigated is by using retransplantation.
14. Hamano K, Rawsthorne M, Bushell A, Morris P, Wood K: Donor microchimerism is not responsible for the maintenance of tolerance to donor alloantigens in recipients of tolerant cardiac allografts. Transplant Proc 1995, 27:151-152.
15. Scully R, Qin S, Cobbold S, Waldmann H: Mechanisms in CD4 antibody-mediated transplantation tolerance: kinetics of induction, antigen dependency and role of regulatory T cells. Eur J Immunol 1994, 24:2383-2392.
16. Wood ML, Monaco AP: Induction of unresponsiveness to skin allografts in adult mice disparate at defined regions of the H-2 complex: II. Effect of donor-specific bone marrow in ALS-treated mice. Transplantation 1984, 37:35-39.
17. Thomas JM, Carver FM, Cunningham PR, Olson LC, Thomas FT: Kidney allograft tolerance in primates without chronic immunosuppression: the role of veto cells. Transplantation 1991, 51:198-207.
18. Bushell A, Pearson T, Morris P, Wood K: Donor recipient microchimerism is not required for tolerance induction following recipient pretreatment with donor specific transfusion and anti-CD4 antibody: evidence for a clear role for short term antigen persistence. Transplantation 1995, 59:1367-1371. The data from this study rule out an essential role for donor microchimerism in the induction of tolerance using combined pretreatment with donor alloantigen in the form of blood transfusion and anti-CD4 monoclonal antibody. The data support the view that there are multiple mechanisms by which tolerance to an allograft can be induced.
19. Mackall C, Fleisher T, Brown M, Andrich M, Chen C, Feuerstein I, Horowitz M, Magrath I, Shad A, Steinberg S, et al.: Age, thymopoiesis, and CD4+ T-lymphocyte regeneration after intensive chemotherapy. N Engl J Med 1995, 332:143-149. An important study examining the ability of the thymus to produce T cells after chemotherapy. Although this study does not directly address the role of the thymus in the unmanipulated adult, the findings are relevant to strategies using intrathymic injection of donor alloantigens in adult recipients.
20. Tomita Y, Khan A, Sykes M: Role of intrathymic clonal deletion and peripheral energy in transplantation tolerance induced by bone marrow transplantation in mice conditioned with a non-myeloablative regimen. J Immunol 1994, 153:1087. These interesting findings show that donor bone marrow cells can migrate to the thymus after intravenous administration in adult mice and that the presence of donor bone marrow cells in the thymus leads to deletion of donor reactive thymocytes.
21. Vojtiskva M, Lengerova A: Thymus-mediated tolerance to cellular alloantigens. Transplantation 1968, 6:13-24.
22. Posselt AM, Barker CF, Tomaszewski JE, Markmann JF, Choti MA, Naji A: Induction of donor-specific unresponsiveness by intrathymic islet transplantation. Science 1990, 249:1293-1295.
23. Oluwole S, Jin M, Chowdhury N, Endlestad K, Ohajekwe O, James T: Induction of peripheral tolerance by intrathymic inoculation of soluble alloantigens: evidence for the role of host antigen processing cells and suppressor cell mechanism. Cell Immunol 1995, 162:33-41.
24. Sayegh MH, Perico N, Imberti O, Hancock WW, Carpenter CB, Remuzzi G: Thymic recognition of class II major histocompatibility complex allopeptides induces donor-specific unresponsiveness to renal allografts. Transplantation 1993, 56:461-465.
25. Kline GZS, Mohiuddin M, Rostami S, DiSesa V: Tolerance to experimental cardiac allografts produced by neonatal intrathymic injection of donor cells. Ann Thorac Surg 1994, 58:1316-1319.
26. Light B, Rivas P, Blanchard J, Tetali S, Chou D, Lazda V, Pollak R: Effects of delayed intrathymic donor splenocyte infusion on cardiac allograft survival in antilymphocyte serum-treated rats. Transplantation 1995, 59:429-432.
27. Ohzato H, Monaco AP: Induction of specific unresponsiveness (tolerance) to skin allografts by intrathymic donor-specific splenocyte injection in anti lymphocyte serum-treated mice. Transplantation 1992, 54:1090-1095.
28. Turka LA, Linsley PS, Lin H, Brady W, Leiden JM, Wei R-Q, Gibson ML, Zheng X-G, Myrdal S, Gordon D, et al.: T cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo. Proc Natl Acad Sci U S A 1992, 89:11102-11105.
29. Lin H, Bolling S, Linsley P, Wei R, Gordon D, Thompson C, Turka L: Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion. J Exp Med 1993, 1801-1806.
30. Sayegh M, Akalin E, Hancocock W, Russell M, Carpenter C, PS L, Turka L: CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2. J Exp Med 1995, 181:1869-1874. An examination of the mechanisms responsible for the induction of tolerance in vivo as a result of blocking the delivery of the second signal using CTLA4-Ig. The immunohistochemical data presented in the paper show that the leukocyte-infiltrating grafts in rats treated with CTLA4-Ig express Th2 cytokines. The authors suggest that deviation of the immune response to a Th2 cytokine phenotype is responsible for the induction of tolerance using this strategy.
31. Qin L, Chavin K, Ding Y, Favaro J, Woodward J, Lin J, Tahara H, Robbins P, Shaked A, Ho D, et al.: Multiple vectors effectively achieve gene transfer in a murine cardiac transplantation model. Transplantation 1995, 59:809-816. This interesting study explores the use of gene therapy to deliver cytokine genes to tissue immediately before transplantation in an attempt to prevent graft rejection. The data presented show that expression of viral interleukin-10 and TGFβ in heart tissue before transplantation can lead to prolongation of graft survival.
32. Crystal R: Transfer of genes to humans: early lessons and obstacles to success. Science 1995, 270:404-410.