Discovery of a linear lead antagonist to the insect pheromone biosynthesis activating neuropeptide (PBAN)

Peptides

Volumn 21, Issue 10, 2000, Pages 1457-1465

  Zeltser, Irina ^a   Gilon, Chaim ^a   Ben Aziz, Orna ^b   Schefler, Irit ^b   Altstein, Miriam ^b  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b VOLCANI CENTER   (Israel)

Author keywords

Heliothis peltigera; Insect neuropeptides; Neuropeptide antagonists; PBAN; Pheromone biosynthesis

Indexed keywords

HORMONE ANTAGONIST; NEUROPEPTIDE; SEX PHEROMONE;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; BIOSYNTHESIS; FEMALE; INSECT; MOTH; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMAL; FEMALE; MOTHS; NEUROPEPTIDES; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; PEPTIDE LIBRARY; PHEROMONES; SUPPORT, NON-U.S. GOV'T;

HELIOTHIS; INSECTA; LEPIDOPTERA; PELTIGERA;

EID: 0033791717     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-9781(00)00298-9     Document Type: Article

References (67)

1. Pheromonotropic activity of naturally occurring pyrokinin insect neuropeptides (FXPRLamide) in Helicoverpa zea
2. Neuroendocrine control of sex pheromone biosynthesis in Heliothis peltigera
3. PBAN-induced sex pheromone biosynthesis in Heliothis peltigera; structure, dose and time-dependent analysis
4. Induction of cuticular melanization in Spodoptera littoralis larvae by PBAN/MRCH; development of a quantitative bioassay and structure function analysis
5. Structure-function relationship of PBAN/MRCH
6. Structure-function analysis of PBAN/MRCH; a basis for antagonist design
7. Backbone cyclic peptide antagonists, derived from the insect pheromone biosynthesis activating neuropeptide (PBAN), inhibit sex pheromone biosynthesis in moths
8. Ligands for κ-opioid and ORL1 receptors identified from a conformationally constrained peptide combinatorial library
9. Isolation and identification of the cDNA encoding the pheromone biosynthesis activating neuropeptide and additional neuropeptides in the oriental tobacco budworm, Helicoverpa assulta (Lepidoptera; Noctuidae)
10. 21; development of endothelin-B receptor selective antagonists
11. 3]DPDPE
12. A novel bombesin antagonist with reduced peptide bond
13. 50s for cellular secretion and growth approaching the picomolar region
14. Molecular cloning of the pheromone biosynthesis-activating neuropeptide in Helicoverpa zea
15. Female sex pheromone components of Heliothis peltigera (Lepidoptera:Noctuidae); chemical identification from gland extracts and male response
16. The pheromone biosynthesis activating neuropeptide (PBAN) of the black cutworm moth, Agrotis ipsilon; immunohistochemistry, molecular characterization and bioassay of its peptide sequence
17. Biological evaluation of substance P antagonists
18. Functional cross-reactivity of some locustamyotropins and Bombyx pheromone biosynthesis activating neuropeptide
19. The explosion of structural information on insect neuropeptides
20. Effect of synthetic PBAN and derived peptides on sex pheromone biosynthesis in Heliothis peltigera (Lepidoptera; Noctuidatae)
21. Rationally designed neuropeptide antagonists; a novel approach for generation of environmentally friendly insecticides
22. 12]bombesin analogues; a new class of bombesin receptor antagonists
23. General method for the rapid solid-phase synthesis of large numbers of peptides; specificity of antigen-antibody interaction at the level of individual amino acids
24. Structural and conformation related to the activity of peptide hormones
25. Relation of conformation to biological activity in oxytocin, vasopressin and their analogues
26. Emerging approaches in the molecular design of receptor-selective peptide ligands; conformational, topographical and dynamic considerations
27. Strategies in the development of peptide antagonists
28. Isolation and structure of diapause hormone of the silkworm, Bombyx mori
29. cDNA cloning and sequence determination of the pheromone biosynthesis activating neuropeptide of Mamestra brassicae; a new member of the PBAN family
30. c-DNA cloning and sequence determination of the pheromone biosynthesis activating neuropeptide of the silkworm, Bombyx mori
31. Molecular cloning of a new type of c-DNA for pheromone biosynthesis activating neuropeptide in the silkworm, Bombyx mori
32. Amino acid sequence of pheromone-biosynthesis-activating neuropeptide (PBAN) of the silkworm Bombyx mori
33. Amino acid sequence of pheromone biosynthesis activating neuropeptide-II (PBAN-II) of the silkmoth Bombyx mori
34. Structure-activity relationship in C-terminal fragments analogs of pheromone biosynthesis activating neuropeptide in Helicoverpa zea
35. Further proctolin analogues modified in the position 2 of the peptide chain and their myotropic effects in insects Tenebrio molitor and Schistocerca gregaria
36. Structure-activity relationship of pheromone biosynthesis activating neuropeptide (PBAN) from the silkmoth, Bombyx mori
37. N-terminal modified analogs of C-terminal fragments of PBAN with pheromonotropic activity
38. Cross-activity between pheromone biosynthesis activating neuropeptide (PBAN) and myotropic pyrokinin insect peptides
39. Synthesis and biological activities of potent bombesin receptor antagonists
40. Structural organization of the Helicoverpa zea gene encoding the precursor protein for pheromone biosynthesis-activating neuropeptide and other neuropeptides
41. 12-containing lactam-bridged parathyroid hormone-related protein-derived antagonist
42. Isolation and identification of a pheromonotropic neuropeptide from the brain-suboesophageal ganglion complex of Lymantria dispar; a new member of the PBAN family
43. Functional diversity of a neurohormone produced by the suboesophageal ganglion; molecular identity of melanization and reddish colouration hormone and pheromone biosynthesis activating neuropeptide
44. Isolation and primary structure of a novel pheromonotropic neuropeptide structurally related to leucopyrokinin from the armyworm larvae, Pseudaletia separata
45. Modulation of the action of regulatory peptides by structural modifications
46. Active fragments and analogs of the insect neuropeptide leucopyrokinin; structure-function studies
47. Leads for insect neuropeptide mimetic development
48. Pupariation acceleration in fleshfly (Sarcophaga bullata) larvae by the pyrokinin/PBAN neuropeptide family
49. Structure and activity of Bombyx PBAN
50. Behavioral evidence that substance P may be a spinal cord nociceptor neurotransmitter
51. Brain factor control of sex pheromone production in the female corn earworm moth
52. Identification of a neuropeptide hormone that regulates sex pheromone production in female moths
53. A pentapeptide of the C-terminal sequence of PBAN with pheromonotropic activity
54. Pheromone biosynthesis activating neuropeptide regulation of pheromone production in moths
55. Structure activity studies of PBAN of Helicoverpa zea (Lepidoptera; Noctuidae)
56. Neuroendocrine control of sex pheromone biosynthesis in Lepidoptera
57. Synthesis and biological activities of analogues of the luteinizing hormone-releasing hormone (LH-RH) modified in position 2
58. Structure-activity studies of bradykinin and related peptides
59. Synthesis and biological activity of partially modified retro-inverso pseudopeptide derivatives of the C-terminal tetrapeptide of gastrin
60. The pharmacological profile of a substance P (SP) antagonists. Evidence for the existence of subpopulations of SP receptors
61. Vasopressin analogs that antagonisze antidiuretic responses by rats to the antidiuretic hormone
62. Isolation, primary structure, and synthesis of locustapyrokinin; a myotropic peptide of Locusta migratoria
63. The myotropic peptides of Locusta migratoria; structures, distribution, functions and receptors
64. Pheromone biosynthesis activating neuropeptides; functions and chemistry
65. Synthetic polypeptide antagonists of the hypothalamic luteinizing hormone releasing hormone
66. Competitive antagonists of bradykinin
67. Peptidomimetics derived from natural products