Conformational studies of a potent Leu11,D-Trp12-containing lactam- bridged parathyroid hormone-related protein-derived antagonist

Journal of Peptide Research

Volumn 52, Issue 3, 1998, Pages 241-248

  Maretto, S ^a   Schievano, E ^a   Mammi, S ^a   Bisello, A ^b   Nakamoto, C ^b   Rosenblatt, M ^b   Chorev, M ^b   Peggion, E ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Antagonist; Conformational analysis; Lactam; Parathyroid hormone related peptide

Indexed keywords

LACTAM; PARATHYROID HORMONE RECEPTOR; PARATHYROID HORMONE RELATED PROTEIN; PARATHYROID HORMONE RELATED PROTEIN[7-34]; PARATHYROID HORMONE[1-34]; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CHEMICAL STRUCTURE; CIRCULAR DICHROISM; HORMONE RECEPTOR INTERACTION; NUCLEAR MAGNETIC RESONANCE; PARATHYROID GLAND; PEPTIDE ANALYSIS; PRIORITY JOURNAL;

EID: 0031712573     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-3011.1998.tb01481.x     Document Type: Article

References (32)

1. Potts, Jr., J.T., Kronenberg, H.M. & Rosenblatt, M. (1982) Adv. Protein. Chem. 35, 323-396.
2. Habener, J.F., Rosenblatt, M. & Potts, Jr., J.T. (1984) Physiol. Rev. 64, 985-1053.
3. Suva, L.J., Winslow, G. A., Wettenhall, R.E.H., Hamrnonds, R.G., Moseley, J.M., Diefenbach-Jagger, H., Rodda, C.P., Kemp, B.E., Rodriguez, H., Chen, E.Y., Hudson, P.J., Martin Jr., T.J. & Wood W.I. (1987) Science 137, 893-896.
4. Moseley, J.M., Kubota, M., Diefenbach-Jagger, H., Wettenhall, R.E.H., Kemp, B.E., Suva, L.J., Rodda, C.P., Ebeling, P.R., Hudson, P.J., Zajac, J.D. & Martin, Jr., T.J. (1987) Proc. Natl. Acad. Sci. USA 84, 5048-5052.
5. Kemp, B.E., Moseley, J.M., Rodda, C.P., Ebeling, P.R., Wettenhall, R.E.H., Stapleton, D., Diefenbach-fagger, H., Ure, F., Michelangeli, V.P., Simmons, H.A., Raisz, L.G. & Martin Jr., T.J. (1987) Science 238, 1568-1570.
6. Yates, A.J.P., Gutierrez, G.E., Smolens, P., Travis, P.S., Katz, M.S., Aufdemorte, T.B., Boyces, B.F., Hymer, T.K., Poser, J.W. & Mundy, G.R. (1988) J. Clin. Invest. 81, 932-939.
7. Horiuchi, N., Caulfield, M.P., Fisher, J.E., Goldman, M.E., McKee, R.L., Reagan, J.E., Levy, J.J., Nutt, R.F., Rodan, S.B., Schofield, T.L., Clemens, T.L. & Rosenblatt, M. (1987) Science 238, 1566-1568.
8. McKee, R.L., Goldman, M.E., Caulfield, M.P., DeHaven, P.A., Levy, J.J., Nutt, R.F. & Rosenblatt, M. (1988) Endocrinology 122, 3008-3010.
9. Horiuchi, N., Caulfield, M.P., Nutt, R.F., Levy, J.J., Rosenblatt, M. & Clemens, T.L. (1989) Proceedings from the 71st Annual Meeting of the Endocrine Society, June 21-24, Seattle, WA, Abstr. 618.
10. Chorev, M., Goldman, M.E., McKee, R.L., Roubini, E., Levy, J.J., Gay, C.T., Reagan, J.E., Fisher, J.E., Caporale, L.H., Golub, E.E., Caufield, M.P., Nutt, R.F. & Rosenblatt, M. (1990). Biochemistry 29, 1580-1586.
11. Chorev, M. & Rosenblatt, M. (1994) in Parathyroids. Basics and Clinical Concepts (Bilezikian, J.P., Levine M. &. Marcus, R., eds.), Raven Press, Ltd., New York, pp. 139-156.
12. Nutt, R.F., Caulfield, M.P., Levy, J.J., Gibbons, S.W., Rosenblatt, M. & McKee, R.L. (1990) Endocrinology 127, 491-493.
13. Chorev, M., Behar, V., Yang, Q.M., Rosenblatt, M., Mammi, S., Maretto, S., Pellegrini, M. & Peggion, E. (1995) Biopolymers 36, 485-495.
14. Neugebauer, W., Surewicz, W.K., Gordon, H.L., Somorjai, R.L., Sung, W. & Willick, G.E. (1992) Biochemistry 31, 2056-2063.
15. Wray, V., Federau, T., Gronwald, W., Mayer H., Schomburg, D., Tegge, W. & Wingender E. (1994) Biochemistry 33, 1684-1693.
16. Chorev, M., Roubini, E., McKee, R.L., Gibbons, S.W., Goldman, M.E., Caulfield, M.P. & Rosenblatt, M (1991) Biochemistry 30, 5968-5974.
17. Bisello, A., Nakamoto, C., Rosenblatt, M. & Chorev, M. (1997) Biochemistry 36, 3293-3299.
18. Drobny, G., Pines, A., Sinton, S., Weitekamp, D., & Wemmer, D. (1979) Faraday Symp. Chem. Soc. 13, 49-55.
19. Bodenhausen, G., Vold, R.L. & Vold, R.R.(1980) J. Magn. Reson. 37, 93-106.
20. Piantini, U., Sørensen, O. W. & Ernst, R. R. (1982) J. Am.Chem. Soc. 104, 6800-6801.
21. Derome, A.E. & Williamson, M. P. (1990). J. Magn. Reson. 88, 177-185.
22. Bax, A. & Davis, D.G. (1985) J. Magn. Reson. 65, 355-360.
23. Griesinger, C., Otting, G., Wüthrich, K. & Ernst, R.R. (1988) J. Am. Chem. Soc. 110, 7870-7872.
24. Macura, S. & Ernst, R.R. (1982) Mol. Phys. 41, 95-117.
25. Macura, S., Huang, Y., Suter, D. & Ernst, R.R. (1981) J. Magn. Reson. 43, 259-281.
26. Wüthrich, K. Billeter, M. & Braun, W. (1983) J. Mol. Biol. 169, 949-961.
27. Güntert, P., Braun, W. & Wüthrich, K. (1991). J. Mol. Biol. 217, 517-530.
28. Güntert, P. (1992) DIANA (Version 2.1) User's Manual and Instruction, ETH, Zürich, Switzerland.
29. Pastore, A. & Saudek, V. (1990) J. Magn. Reson. 90, 165-176.
30. Maretto, S., Mammi, S., Bissacco, E., Peggion, E., Bisello, A., Rosenblatt, M., Chorev, M. & Mierke, D.F. (1997) Biochemistry 36, 3300-3307.
31. Chorev, M., Epand, R.F., Rosenblatt, M., Caulfield, M.P. & Epand, R.M. (1993) Int. J. Pept. Protein Res. 42, 342-345.
32. Mierke, D.F., Maretto, S., Schievano, E., Deluca, D., Bisello, A., Mammi, S., Rosenblatt, M., Peggion, E. & Chorev, M. (1997) Biochemistry 36, 10372-10383.