Selenium in biology: Facts and medical perspectives

Biological Chemistry

Volumn 381, Issue 9-10, 2000, Pages 849-864

  Kohrle, J ^a   Brigelius Flohe, R ^a   Bock, A ^a   Gartner, R ^a   Meyer, O ^a   Flohe, L ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Biosynthesis; Medical implications; Redox regulation; Selenoproteins; Sperm maturation; Thyroid function

Indexed keywords

AMINO ACID DERIVATIVE; CARBON MONOXIDE DEHYDROGENASE; CYSTEINE; ETHER DERIVATIVE; GLUTATHIONE PEROXIDASE; METHIONINE DERIVATIVE; SELENIUM; SELENOCYSTEINE; SELENOPROTEIN; SYNTHETASE; THIOREDOXIN REDUCTASE; THYROID HORMONE; THYROXINE DEIODINASE; TRACE ELEMENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ATHEROSCLEROSIS; BACTERIAL INFECTION; BIOSYNTHESIS; CARCINOGENESIS; CATALYSIS; CONTROLLED STUDY; DRUG EFFICACY; ENERGY METABOLISM; ENZYME ACTIVITY; ESCHERICHIA COLI; EUKARYOTE; HORMONAL REGULATION; MALE INFERTILITY; MOLECULAR BIOLOGY; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROKARYOTE; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; RAT; REVIEW; SELENIUM DEFICIENCY; THYROID HORMONE METABOLISM; TISSUE SPECIFICITY; VIRUS INFECTION;

ANIMALIA; BACTERIA (MICROORGANISMS); EMBRYOPHYTA; ESCHERICHIA COLI; EUKARYOTA; PROKARYOTA; RODENTIA; VERTEBRATA;

EID: 0033790451     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2000.107     Document Type: Review

References (192)

1. Cloning, expression, and chromosomal localization of the rat mitochondrial capsule selenoprotein gene (MCS): The reading frame does not contain potential UGA selenocysteine codons
2. Formate dehydrogenase of Clostridium thermoaceticum: Incorporation of selenium-75, and the effect of selenite, molybdate and tungstate on the enzyme
3. Various functions of selenols and thiols in anaerobic gram-positive, amino acid-utilizing bacteria
4. Selenium replacement in patients with severe systemic inflammatory response syndrome improves clinical outcome
5. Isolation and characterization of a covalent selenocysteine intermediate in the glycine reductase system
6. Protection by selenoprotein P in human plasma against peroxynitrite-mediated oxidation and nitration
7. Protection against peroxinitrite
8. Binding of selenoprotein P to heparin: Characterization with surface plasmon resonance
9. Hepatic iodothyronine 5'-deiodinase. The role of selenium
10. Glutathione peroxidase revisited. Simulation of the catalytic cycle by computer-assisted molecular modelling
11. Selenium supplementation by selenium yeast and sodium selenite: Analysis of the selenium status as well as risks of deficiency and intoxication
12. Interaction of translation factor SELB with the formate dehydrogenase H selenopolypeptide mRNA
13. Glutathione peroxidase protects mice from viral-induced myocarditits
14. Identification of type I iodothyronine 5'-deiodinase as a selenoenzyme
15. Newly found selenium-containing proteins in the tissues of the rat
16. Two new selenoproteins found in the prostatic glandular epithelium and in the spermatid nuclei
17. Recognition of UGA as a selenocysteine codon in type I deiodinase requires sequences in the 3' untranslated region
18. Functional characterization of the eukaryotic SECIS elements which directs selenocysteine insertion at UGA codons
19. Selenite and selenodiglutathione: Reactions with thioredoxin systems
20. Selenium and the thioredoxin and glutaredoxin systems
21. Biosynthesis of selenoproteins - An overview
22. Selenocysteine, a highly specific component of certain enzymes, is incorporated by a UGA directed co-translational mechanism
23. Selenoprotein synthesis: An expansion of the genetic code
24. Selenocysteine: The 21st amino acid
25. Early embryonic lethality caused by targeted disruption of the mouse selenocysteine tRNA gene (Trsp)
26. Crystal structure of formate dehydrogenase H: Catalysis involving Mo, molybdopterin, selenocysteine, and an Fe4S4 cluster
27. Tissue-specific functions of individual glutathione peroxidases
28. Phospholipid hydroperoxide glutathione peroxidase
29. Interleukin-1-induced nuclear factor kB activation is inhibited by overexpression of phospholipid hydroperoxide glutathione peroxidase in a human endothelial cell line
30. Regulation of selenoproteins
31. A selenium-rich extracellular glycoprotein
32. Evidence that selenium in rat sperm is associated with cysteine-rich structural protein of the mitochondrial capsules
33. Developmental expression, intracellular localization, and selenium content of the cysteine-rich protein associated with the mitochondrial capsules of mouse sperm
34. The structure of the mouse glutathione peroxidase gene: The selenocysteine in the active site is encoded by the 'termination' codon, TGA
35. Cellular glutathione peroxidase is the mediator of body selenium to protect against paraquat lethality in transgenic mice
36. Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI
37. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin
38. Structure-activity relationships of flavonoid deiodinase inhibitors and enzyme active-site models
39. Reduction of cancer risk with an oral supplement of selenium
40. Chemopreventive agents: Selenium
41. Chemical characterization of the selenoprotein component of clostridial glycine reductase: Identification of selenocysteine as the organoselenium moiety
42. Selenium deficiency aggravates the necrotizing effects of a high iodide dose in iodine deficient rats
43. Selenium deficiency and thyroid fibrosis. A key role for macrophages and transforming growth factor (TGF-β)
44. A novel RNA binding protein, SBP2, is required for the translation of mammalian selenoprotein mRNAs
45. Identification of oxygen responsive elements in the 5'-flanking region of the human glutathione peroxidase gene
46. Cloning and expression of a cDNA for a mammalian type III iodothyronine deiodinase
47. Cloning of a cDNA for the type II iodothyroine deiodinase
48. Modulation of natural killer cell activity by selenium in humans
49. The nature of the acid-volatile selenium in the liver of the male rat
50. Crystal structure and mechanism of CO dehydrogenase, a molybdo iron-sulfur flavoprotein containing S-selanylcysteine
51. Cloning and characterization of the human selenoprotein P promotor: Response of selenoprotein P expression to cytokines in liver cells
52. The biochemistry of endemic cretinism: Roles of iodine and selenium deficiency and goitrogens
53. The refined structure of the selenoenzyme glutathione peroxidase at 0.2-nm resolution
54. The selenoprotein glutathione peroxidase
55. Glutathione peroxidase: A selenoenzyme
56. Regulation of glutathione peroxidases
57. Glutathione and trypanothione in parasitic hydroperoxide metabolism
58. Selenium, the element of the moon in life on earth
59. Thioredoxins: Universal, yet specific thiol-disulfide redox cofactors
60. Selenium, systemic immune response syndrome, sepsis, and outcome in critically ill patients
61. The function of selenocysteine synthase and SELB in the synthesis and incorporation of selenocysteine
62. Identification of the catalytic site of rat liver glutathione peroxidase as selenocysteine
63. 13-HPODE and 13-HODE modulate cytokine-induced expression of endothelial cell adhesion molecules differently
64. Knockout of cellular glutathione peroxidase gene renders mice susceptible to diquat-induced oxidative stress
65. Selenium metabolism, selenoproteins and mechanisms of cancer prevention: Complexities with thioredoxin reductase
66. Physiological mechanisms regulating the conversion of selenite to elemental selenium by Bacillus subtilis
67. The crystal structure of a reduced [NiFeSe] hydrogenase provides an image of the activated catalytic center
68. Selenium administration in sepsis patients
69. Cloning, sequencing and functional expression of a novel human thioredoxin reductase
70. The epidemiology of selenium deficiency in the etiological study of endemic diseases in China
71. Properties of the selenium- and molybdenum-containing nicotinic acid hydrolase from Clostridium barkeri
72. A new human selenium-containing protein
73. Pre-diagnostic serum selenium in a case-control study of thyroid cancer
74. The penultimate selenocysteine residue at the C-terminus of mammalian thioredoxin reductase plays an obligatory role in the NADPH-disulfide oxidoreductase catalytic mechanism
75. A hypothesis on the catalytic mechanism of the selenoenzyme thioredoxin reductase
76. Differential selenium-dependent expression of type I 5'-deiodinase and glutathione peroxidase in the porcine epithelial kidney cell line LLC-PK1
77. Identification of a novel seID homolog from eukaryotes, bacteria, and archeae: Is there an autoregulatory mechanism in selenocysteine metabolism?
78. The amino-acid sequence of bovine glutathione peroxidase. Hoppe-Seyler's Z
79. Mice with a homozygous null mutation for the most abundant glutathione peroxidase, GPx1, show increased susceptibility to the oxidative stress-inducing agents paraquat and hydrogen peroxide
80. Chemical engineering of enzymes: Altered catalytic activity, predictable selectivity and exceptional stability of the semisynthetic peroxidase selenosubtilisin
81. Kinetic studies on arachidonate 5-lipoxygenase from rat basophilic leukemia cells
82. Effects of acute illness on selenium homeostasis
83. Oxidoreductive regulation of nuclear factor kappa B. Involvement of a cellular reducing catalyst thioredoxin
84. Determinants and regulation of cytoplasmic mRNA stability in eukaryotic cells
85. Selenoprotein P: Recent studies in rats in humans
86. Mice deficient in cellular glutathione peroxidase develop normally and show no increased sensitivity to hyperoxia
87. Redox regulation by thioredoxin and thioredoxin reductase
88. Thioredoxin and thioredoxin reductase
89. A protein binds the selenocysteine insertion element in the 3'-UTR of mammalian selenoprotein mRNAs
90. Suppression of leukotriene formation in RBL-2H3 cells that overexpressed phospholipid hydroperoxide glutathione peroxidase
91. Lessons from basic research in selenium and cancer prevention
92. Activity of methylated forms of selenium in cancer prevention
93. Glutathione peroxidase-deficient mice are more susceptible to neutrophil-mediated hepatic parenchymal cell injury during endotoxemia: Importance of an intracellular oxidant stress
94. The promotor of the human type I 5'-deiodinase gene: Mapping of the transcription start site and identification of a DR+4 thyroid hormone responsive element
95. Occurrence of selenocysteine in the selenium-dependent formate dehydrogenase of Methanococcus vannielli
96. Identification of D-proline reductase from Clostridium sticklandii as a selenoenzyme and indications for a catalytically active pyruvoyl group derived from a cysteine residue by cleavage of a proprotein
97. Is low selenium status a risk factor for lung cancer?
98. The trace element selenium and the thyroid gland
99. Local activation and inactivation of thyroid hormones: The deiodinase family
100. The selenoenzyme family of deiodinase isoenzymes controls local thyroid hormone availability
101. The deiodinase family - Selenoenzymes regulating thyroid hormone availability and action
102. Glycine reductase of clostridium litorale. Cloning, sequencing, and molecular analysis of the grdAB operon that contains two in-frame TGA codons for selenium incorporation
103. Inhibition of I kappa B-alpha phosphorylation and degradation and subsequent NF-kappa B activation by glutathione peroxidase overexpression
104. New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements
105. Biosynthesis of selenophosphate
106. Catalytic properties of selenophosphate synthetases: Comparison of the selenocysteine-containing enzyme from Haemophilus influenzae with the corresponding cysteine-containing enzyme from Escherichia coli
107. Selenium in plants: Uptake, functions, and environmental toxicity
108. Identification of a selenocysteyl-tRNA-Ser in mammalian cells that recognizes the nonsense codon UGA
109. Molecular cloning and characterization of a mitochondrial selenocysteine-containing thioredoxin reductase from rat liver
110. Mammalian thioredoxin reductase: Oxidation of the C-terminal cysteine/selenocysteine active site forms a thioselenide, and replacement of selenium with sulfur markedly reduces catalytic activity
111. Glutathione peroxidase and phospholipid hydroperoxidie glutathione peroxidase are differentially regulated in rats by dietary selenium
112. Escherichia coli genes whose products are involved in selenium metabolism
113. In vitro synthesis of selenocysteinyl-tRNA(UCA) involvement and characterization of the seID gene product
114. Novel selenoproteins identified in silico and in vivo by using a conserved RNA structural motif
115. An RNA-binding protein recognizes a mammalian selenocysteine insertion sequence element required for cotranslational incorporation of selenocysteine
116. Knowing when not to stop: Selenocysteine incorporation in eukaryotes
117. Cloning and functional characterization of human selenophosphate synthetase, an essential component of selenoprotein synthesis
118. Probing the presumed catalytic triad of selenium-containing peroxidases by mutational analysis of phospholipid hydroperoxide glutathione peroxidase (PHGPx)
119. A selenium-containing phospholipid-hydroperoxide glutathione peroxidase in Schistosoma mansoni
120. Testosterone mediates expression of the selenoprotein PHGPx by induction of spermatogenesis and not by direct transcriptional gene activation
121. Selenium and reproduction
122. Direct association with thioredoxin allows redox regulation of glucocorticoid receptor function
123. Evidence for a functional relevance of the selenocysteine residue in mammalian thioredoxin reductase
124. Early embryonic lethality caused by targeted disruption of the mouse thioredoxin gene
125. Selenium: An essential element for immune function
126. Hemoglobin catabolism. I. Glutathione peroxidase, an erythrocyte enzyme which protects hemoglobin from oxidative breakdown
127. Human mitochondrial thioredoxin reductase
128. Analysis of the phospholipid hydroperoxide glutathione peroxidase mRNA in the rat spermatozoon and effect of selenium deficiency on the mRNA
129. Kashin-Beck osteoarthropathy in rural Tibet in relation to selenium and iodine status
130. Expression pattern of gastrointestinal selenoproteins
131. Transforming growth factor β1 inhibits expression of selenoprotein P in cultured human liver cells
132. Effect of dietary selenium on plasma selenoprotein P, selenoprotein P1 and glutathione peroxidase in the rat
133. Eukaryotic selenocysteine incorporation follows a non-processive mechanism that competes with translational termination
134. A family of S-methylmethionine-dependent thiol/selenol methyltransferases. Role in selenium tolerance and evolutionary relation
135. Bull sperm selenium is bound to a structural protein of mitochondria
136. Fusion of two subunits does not impair the function of a (NiFeSe)-hydrogenase in the archaeon Methanococcus voltae
137. The need for selenite and molybdate in the formation of formic dehydrogenase by members of the Coli-aerogenes group of bacteria
138. Free radical generation, lipid peroxidation and essential fatty acids in patients with septicemia
139. A family of novel peroxidases, peroxiredoxins
140. Trace elements and lipid peroxidation abnormalities in patients with chronic renal failure
141. Serum selenium, copper, and zinc concentrations in Crohn's disease and ulcerative colitis
142. Glutathione deficiency increases organ dysfunction after hemorrhagic shock
143. Purification and properties of a recombinant sulfur analog of purine selenium-glutathione peroxidase
144. Identification and characterisation of the selenocysteine-specific translation factor SelB from the archaeon Methanococcus jannaschii
145. Relationship of selenium to GSH peroxidase
146. Molecular cloning of cDNA encoding a bovine selenoprotein P-like protein containing 12 selenocysteines and a (His-Pro) rich domain insertion, and its regional expression
147. Selenoprotein P in human plasma as an extracellular phospholipid hydroperoxide glutathione peroxidase - Isolation and enzymatic characterization of human selenoprotein P
148. Selenium in ischaemic heart disease
149. Platelet glutathione peroxidase activity in long-term total parenteral nutrition with and without selenium supplementation
150. Strong inhibition of mammalian lipoxygenases by the antiinflammatory seleno-organic compound ebselen in the absence of glutathione
151. Selensubstitution - Ein therapeutischer Ansatzpunkt bei Schilddrusenerkrankungen
152. Functional retinoid and thyroid hormone receptors in human thyroid carcinoma cell lines and tissues
153. The selenoenzyme phospholipid hydroperoxide glutathione peroxidase controls the activity of the 15-lipoxygenase with complex substrates and preserves the specificity of the oxygenation products
154. Selenium-containing xanthine dehydrogenase from Eubacterium barkeri
155. Phospholipid hydroperoxide glutathione peroxidase is a selenoenzyme distinct from the classical glutathione peroxidase as evident from cDNA and amino acid sequencing
156. 3-responsive gene in human osteoblast - Regulation by selenite
157. Neue menschliche Selenoproteine: Selenoprotein P und Thioredoxin-Reduktase
158. GPx3: The plasma-type glutathione peroxidase is expressed under androgenic control in the mouse epididymis and vas deferens
159. Selenium as an integral part of factor 3 against dietary necrotic liver degeneration
160. RNA-binding proteins that specifically recognize the selenocysteine insertion sequence of human cellular glutathione peroxidase mRNA
161. Identification and molecular cloning of a human selenocysteine insertion sequence-binding protein
162. Oxidation in the NADP system and release of GSSG from hemoglobin-free perfused rat liver during peroxidatic oxidation of glutathione by hydroperoxides
163. Glutathione peroxidase protects against peroxynitrite-mediated oxidations. A new function for selenoproteins as peroxynitrite reductase
164. Oxygenation of polyunsaturated fatty acids during prostaglandin biosynthesis by sheep vesicular gland
165. Selenium biochemistry
166. Low density lipoprotein oxidation and its pathological significance
167. Analysis of the mouse selenoprotein P gene
168. Intracellular glutathione peroxidases - Structure, regulation and function
169. Purification and characterization of human plasma glutathione peroxidase: A selenoglycoprotein distinct from the known cellular enzyme
170. A new selenoprotein from human lung adenocarcinoma cells: Purification, properties, and thioredoxin reductase activity
171. Purification of protein components of the clostridial glycine reductase system and characterization of protein A as a selenoprotein
172. Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxides
173. Diversity of glutathione peroxidases
174. Dual function of the selenoproteins PHGPx during sperm maturation
175. Rat skeletal muscle selenoprotein W: cDNA clone and mRNA modulation by dietary selenium
176. A selenium-dependent and a selenium-independent formylmethanofuran dehydrogenase and their transcriptional regulation in the hyperthermophilic Methanopyrus kandleri
177. Substrate-specific selenoprotein B of glycine reductase from Eubacterium acidaminophilum. Biochemical and molecular analysis
178. Mitochondrial thioredoxin reductase in bovine adrenal cortex its purification, properties, nucleotide/amino acid sequences, and identification of selenocysteine
179. Selenoenzymes regulate the activity of leukocyte 5-lipoxygenase via the peroxide tone
180. The Selenium Moiety of Glutathione Peroxidase. Hoppe-Seyler's Z
181. Selenoprotein W cDNAs from five species of animals
182. Selenoprotein synthesis in Archaea: Identification of an mRNA element of Methanococcus jannaschii probably directing selenocysteine insertion
183. mRNA stability and selenocysteine insertion sequence efficiency rank gastrointestinal glutathione peroxidase high in the hierarchy of selenoproteins
184. Gastrointestinal glutathione peroxidase
185. A new translational elongation factor for selenocysteyl-tRNA in eukaryotes
186. Glutathione peroxidase isolated from plasma reduces phospholipid hydroperoxides
187. Gene expression in macrophage-rich human atherosclerotic lesions. 15-lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts
188. Purification from bovine serum of a survival-promoting factor for cultured central neurons and its identification as selenoprotein-P
189. Selenium administration in patients with sepsis syndrome. A prospective randomized study
190. Nucleotide sequence and expression of the selenocysteine-containing polypeptide of formate dehydrogenase (formate-hydrogen-lyase-linked) from Escherichia coli