Redox regulation by thioredoxin and thioredoxin reductase

BioFactors

Volumn 11, Issue 1-2, 2000, Pages 63-64

  Holmgren, Arne ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; THIOREDOXIN; THIOREDOXIN REDUCTASE;

ANIMAL; ARTICLE; BIOSYNTHESIS; CATTLE; GENETICS; HOMEOSTASIS; HUMAN; METABOLISM; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; RAT;

ANIMALS; CATTLE; HOMEOSTASIS; HUMANS; NADPH OXIDASE; OXIDATION-REDUCTION; OXIDATIVE STRESS; RATS; THIOREDOXIN; THIOREDOXIN REDUCTASE (NADPH);

EID: 0033630443     PISSN: 09516433     EISSN: None     Source Type: Journal    
DOI: 10.1002/biof.5520110117     Document Type: Article

References (10)

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2. M. Luthman and A. Holmgren, Rat liver thioredoxin and thioredoxin reductase: purification and characterization, Biochemistry 21 (1982), 6628-6633.
3. A. Holmgren and M. Björnstedt, Thioredoxin and thioredoxin reductase, Methods Enzymol. 252 (1995), 199-208.
4. T. Tamura and T.C. Stadtman, A new selenoprotein from human lung adeno carcinoma cells: purification, properties, and thioredoxin reductase activity, Proc. Natl Acad. Sci. USA 93 (1996), 1006-1011.
5. L. Zhong, E.S.J. Amer, J. Ljung, F. Åslund and A. Holmgren, Rat and calf thioredoxin reductase are homologous to glutathione reductase with a carboxyterminal elongation containing a conserved catalytically active penultimate selenocysteine residue, J. Biol. Chem. 273 (1998), 8581-8591.
6. M. Björnstedt, M. Hamberg, S. Kumar, J. Xue and A. Holmgren, Human thioredoxin reductase directly reduces lipid hydroperoxides by NADPH and selenocystine strongly stimulates the reaction via catalytically generated selenols, J. Biol. Chem. 270 (1995), 11 761-11 764.
7. L. Zhong and A. Holmgren, A.: Selenocysteine is essential for thioredoxin reductase catalysis, submitted.
8. E.S.J. Amer, M. Björnstedt and A. Holmgren, 1-Chloro-2,4-dinitrobenzene (DNCB) is an irreversible inhibitor of human thioredoxin reductase: loss of thioredoxin disulfide reductase activity is accompanied by a large increase in NADPH oxidase activity, J. Biol. Chem. 270 (1995), 3479-3482.
9. J. Nordberg, L. Zhong, A. Holmgren and E.S.J. Arnér, Mammalian thioredoxin reductase is irreversibly inhibited by dinitrohalobenzenes by alkylation of both the redox active selenocysteine and its neighbouring cysteine residue, J. Biol. Chem. 273 (1998), 10 835-10 842.
10. M. Björnstedt, S. Kumar, L. Björkhem, G. Spyrou and A. Holmgren, Selenium and the thioredoxin and glutaredoxin systems, Biomedical and Environmental Sciences 10 (1997), 271-279.