Basal cPLA2 phosphorylation is sufficient for Ca2+ -Induced full activation of cPLA2 in A549 epithelial cells

Journal of Cellular Biochemistry

Volumn 79, Issue 4, 2000, Pages 601-609

  Wen, Hui Chun ^a   Lin, Wan Wan ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

AA release; cPLA2; ERK; PI 3 kinase; PKC

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ARACHIDONIC ACID; CALCIUM ION; EGTAZIC ACID; LY 379196; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOLIPASE A2; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; ROTTLERIN; THAPSIGARGIN; UNCLASSIFIED DRUG; WORTMANNIN;

ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; PRIORITY JOURNAL; WESTERN BLOTTING;

ACETOPHENONES; ARACHIDONIC ACID; BENZOPYRANS; CALCIUM; CELL LINE; CYTOSOL; ENZYME ACTIVATION; ENZYME INHIBITORS; EPITHELIAL CELLS; FLAVONES; HUMAN; INDOLES; MAP KINASE KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOLIPASES A; PHOSPHORYLATION; PROTEIN KINASE C; SUPPORT, NON-U.S. GOV'T; TETRADECANOYLPHORBOL ACETATE; THAPSIGARGIN;

EID: 0033790255     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-4644(20001215)79:4<601::AID-JCB90>3.0.CO;2-W     Document Type: Article

References (40)

1. 2+ and phosphorylation
2. Interleukin-8, interleukin-6, and soluble tumor necrosis factor receptor type I release from pulmonary epithelial cell line (A549) exposed to respiratory syncytial virus
3. Prostaglandin G/H synthase-2 is the constitutive and dominant isoform in cultured human lung epithelial cells
4. 2 in arachidonic acid metabolism in P388D1 macrophages
5. The selective protein kinase C inhibitor, Ro-31-8220 inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression, and activates Jun N-terminal kinase
6. 2 in agonist-stimulated human platelets and HeLa cells
7. 2 is phosphorylated in collagen- and thrombin-stimulated human platelets independent of protein kinase C and mitogen-activated protein kinase
8. 2 with membrane in the macrophage cell line RAW 264.7
9. 2 in endothelial cells
10. 2+ dependent translocation domain with homology to PKC and GAP
11. Platelet-derived-growth-factor stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle: Role of pertussis-toxin-sensitive G-proteins, c-Src tyrosine kinases and phosphoinositide 3-kinase
12. 2
13. 2 expressed in insect cells and present in human monocytes
14. 2
15. 2 superfamily of signal transduction enzymes
16. 2+ indicators with greatly improved fluorescence properties
17. Phosphatidylinositol 3-kinase is an early intermediate in the G beta gamma-mediated mitogen-activated protein kinase signaling pathway
18. 2 by a mitogen-activated protein kinase kinase-independent mechanism in the human astrocytoma cell line 132N1
19. Airway inflamation
20. 2 independent of the mitogen-activated protein kinase Erk1/2
21. 2
22. The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase
23. 2
24. 2
25. 2 is phosphorylated and activated by MAP kinase
26. 2 and adenylyl cyclase by phorbol ester in RAW 264.7 macrophages
27. Pharmacological comparison of UTP- and thapsigargin-induced arachidonic acid release in mouse RAW 264.7 macrophages
28. Influence of calcium on arachidonic acid mobilization by marine resident peritoneal macrophages
29. 2+-independent catalytic domain
30. 2 by p42 microtubule-associated protein 2 kinase and protein kinase C
31. alpha1-Adrenergic receptor stimulation causes arachidonic acid release through pertussis toxin-sensitive GTP-binding protein and JNK activation in rabbit aortic smooth muscle cells
32. 2 from bovine endothelial cells
33. Sphingosine 1-phosphate stimulation of the p42/ p44 mitogen-activated protein kinase pathway in airway smooth muscle. Role of endothelial differentiation gene 1, c-src tyrosine kinase and phosphoinositide 3-kinase
34. 2 to the nuclear envelope and endoplasmic reticulum
35. 2 and the release of arachidonic acid in human neutrophils
36. Activation of calcium entry by the tumor promoter thapsigargin in parotid acinar cells. Evidence that an intracellular calcium pool and not an inositol phosphate regulates calcium fluxes at the plasma membrane
37. 2 gene family in mammals
38. 2 in human neutrophils stimulated with tumor necrosis factor-α
39. 2 are abrogated by an inhibitor of the p38 MAP kinase cascade in human neutrophils
40. 2 in human polymorphonuclear neutrophils