The processing and biological function of the human amyloid precursor protein (APP): Lessons from different cellular models

Experimental Gerontology

Volumn 35, Issue 6-7, 2000, Pages 843-850

  Kienlen Campard, P ^a   Tasiaux, B ^a   Octave, J N ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Alzheimer's disease; Amyloid peptide; APP; Cell line; Neuron; Processing

Indexed keywords

AMYLOID PRECURSOR PROTEIN; AMYLOID PROTEIN; GAMMA SECRETASE; PRESENILIN 1; TAU PROTEIN;

ALZHEIMER DISEASE; APOPTOSIS; CELL SURVIVAL; CONFERENCE PAPER; DEGENERATIVE DISEASE; GENETIC TRANSFECTION; HUMAN; MODEL; NERVE CELL CULTURE; NEUROTOXICITY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROCESSING; SENILE PLAQUE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMAL; CHO CELLS; HAMSTERS; HUMAN; NEURONS; RATS;

EID: 0033788055     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(00)00170-4     Document Type: Conference Paper

References (21)

1. Neuropathological stageing of Alzheimer-related changes
2. Study of the synthesis and secretion of normal and artificial mutants of murine amyloid precursor protein (APP): Cleavage of APP occurs in a late compartment of the default secretion pathway
3. Missense mutations associated with familial Alzheimer's disease in Sweden lead to the production of the amyloid peptide without internalization of its precursor
4. Intraneuronal Aβ 42 accumulation in human brain
5. Amyloid, the presinilins and Alzheimer's disease
6. Identification of a novel aspartic protease (Asp 2) as beta-secretase
7. Inhibition of NF-kappaB potentiates amyloid beta-mediated neuronal apoptosis
8. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
9. The epidemiology of dementia: A review of recent work
10. PACAP type I receptor activation promotes cerebellar neuron survival through the cAMP/PKA signaling pathway
11. Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease
12. The long term adenoviral expression of the human amyloid precursor protein shows different secretase activities in rat cortical neurons and astrocytes
13. Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives
14. Alzheimer amyloid protein precursor complexes with brain GTP - Bindong protein G(o)
15. The amyloid peptide and its precursor in Alzheimer's disease
16. A new monoclonal antibody against the anionic domain of the amyloid precursor protein of Alzheimer's disease
17. Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network
18. Purification and cloning of amyloid precursor protein beta-secretase from human brain
19. Activation of neuronal caspase-3 by intracellular accumulation of wild-type Alzheimer amyloid precursor protein
20. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
21. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity