p53 abnormality and chromosomal instability in the same breast tumor cells

Cancer Genetics and Cytogenetics

Volumn 121, Issue 2, 2000, Pages 150-155

  Sigurdsson, Stefan ^a   Bödvarsdottir, Sigridur K ^a   Anamthawat Jonsson, Kesara ^b   Steinarsdottir, Margret ^c   Jonasson, Jon G ^c   Ögmundsdottir, Helga M ^a   Eyfjörd, Jorunn E ^a  

^a ICELANDIC CANCER SOCIETY   (Iceland)

^b UNIVERSITY OF ICELAND   (Iceland)

^c LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; FORMALDEHYDE; PARAFFIN; PROTEIN P53;

ANEUPLOIDY; ARTICLE; BREAST CARCINOGENESIS; BREAST CARCINOMA; CANCER CELL; CELL CYCLE S PHASE; CENTROMERE; CHROMOSOME 17; CHROMOSOME INSTABILITY; CONTROLLED STUDY; DENATURING GRADIENT GEL ELECTROPHORESIS; DNA SEQUENCE; FLUORESCENCE HISTOCHEMISTRY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE MUTATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INTERPHASE; KARYOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SAMPLE; STAINING; TISSUE SECTION; TUMOR SUPPRESSOR GENE;

BREAST NEOPLASMS; CHROMOSOME ABERRATIONS; GENES, P53; HUMAN; IN SITU HYBRIDIZATION, FLUORESCENCE; SUPPORT, NON-U.S. GOV'T;

EID: 0033787920     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-4608(00)00260-0     Document Type: Article

References (25)

1. p53 abnormalities and genomic instability in primary human breast carcinomas
2. BRCA2 and p53 mutations in primary breast cancer in relation to genetic instability
3. Cytogenetic studies of breast carcinomas; different karyotypic profiles detected by direct harvesting and short-term culture
4. Instability of chromosomes 1, 3, 16, and 17 in primary breast carcinomas inferred by fluorescence in situ hybridization
5. Tp53 mutations and abnormal p53 protein staining in breast carcinomas related to prognosis
6. p53 mutations in human cancers
7. p53, the cellular gatekeeper for growth and division
8. A p53-dependent mouse spindle checkpoint
9. Abnormal centrosome amplification in the absence of p53
10. Centrosome hyperamplification in human cancer; chromosome instability induced by p53 mutation and/or Mdm2 overexpression
11. Genomic instability and poor prognosis associated with abnormal TP53 in breast carcinomas; molecular and immunohistochemical analysis
12. Somatic p53 mutations in human breast carcinomas in an Icelandic population; a prognostic factor
13. Nuclear DNA analysis and prognosis in carcinoma of the thyroid gland; a nationwide study in Iceland on carcinomas diagnosed 1955-1990
14. Simultaneous detection of p53 nuclear protein and chromosome aberrations on sections from formalin-fixed, paraffin-embedded breast cancer tissue
15. A comparison of cytogenetic studies and flow cytometry in breast carcinomas
16. Detection of numeric abnormalities of chromosome 17 and p53 deletions by fluorescence in situ hybridization in pleomorphic adenomas and carcinomas in pleomorphic adenoma; correlation with p53 expression
17. Numerical aberrations of chromosome 17 in interphase cell nuclei of breast carcinoma cells; lack of correlation with abnormal expression of p53, neu and nm23 protein
18. p53 mutations in benign breast tissue
19. p53 mutations analysis in benign and malignant breast lesions; using needle rinses from fine-needle aspirations
20. Immunohistochemical detection of c-erbB-2 and p53 in benign breast disease and breast cancer risk
21. Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer suseptibility gene, Brca2
22. p53 mutations in BRCA1-associated familial breast cancer
23. Characterization of chromosomal anomalies in human breast cancer