Genomic instability and poor prognosis associated with abnormal TP53 in breast carcinomas. Molecular and immunohistochemical analysis

APMIS

Volumn 105, Issue 2, 1997, Pages 121-130

  Valgardsdottir, Rut ^a   Tryggvadottir, Laufey ^a   Steinarsdottir, Margret ^a   Olafsdottir, Kristrun ^a   Jonasdottir, Sigurros ^a   Jonasson, Jon G ^a   Ögmundsdottir, Helga M ^a   Eyfjörd, Jorunn E ^a,b  

^a LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

^b ICELANDIC CANCER SOCIETY   (Iceland)

Author keywords

Breast cancer; Genomic instability; Mutation analysis; TP53

Indexed keywords

ARTICLE; BREAST CARCINOMA; FEMALE; GEL ELECTROPHORESIS; GENE MUTATION; GENOME; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS;

EID: 0030993351     PISSN: 09034641     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1699-0463.1997.tb00550.x     Document Type: Article

References (36)

1. Andersen, T. I., Holm, R., Nesland, J. M., Heimdal, K. R., Ottestad, L. & Borresen, A.-L.: Prognostic significance of TP53 alterations in breast carcinoma. Br. J. Cancer 68: 540-548, 1993.
2. Barnes, D. M., Dublin, E. A., Fisher, C. J., Levison, D. A. & Millis, R. R.: Immunohistochemical detection of p53 protein in mammary carcinoma. An important new independent indicator of prognosis. Hum. Pathol. 24: 469-476, 1993.
3. Bergh, J., Norberg, T., Sjögren, S., Lindgren, A. & Holmberg, L.: Complete sequencing of the p53 gene provides prognostic information in breast cancer patients, particularly in relation to adjuvant systemic therapy and radiotherapy. Nature Med. 1: 1029-1034, 1995.
4. Borg, A., Lennerstrand, J., Stenmark-Askmalm, M., Fernö, M., Brisfors, A., Öhrvik, A., Stal, O., Killander, D., Lane, D. & Brundell, J.: Prognostic significance of p53 overexpression in primary breast cancer; a novel luminometric immunoassay applicable on steroid receptor cytosols. Br. J. Cancer 71: 1013-1017, 1995.
5. Borresen, A.-L., Hovig, E., Smith-Sörensen, B., Malkin, D., Lystad, S., Andersen, T. I., Nesland, J. M., Isselbacher, K. J. & Friend, S. H.: Constant denaturant gel electrophoresis as a rapid screening technique for p53 mutations. Proc. Natl. Acad. Sci. USA (Wash.) 88: 8405-8409, 1991.
6. Børresen, A.-L., Andersen, T. I., Eyfjörd, J. E., Cornelis, R. S., Thorlacius, S., Borg, A., Johansson, U., Theillet, C., Scherneck, S., Hartman, S., Cornelisse, C. J. & Devilee, P.: TP53 mutations and breast cancer prognosis: particularly poor survival rates for cases with mutations in the zinc-binding domains. Genes Chromosom. Cancer 14: 71-75, 1995.
7. Cox, D. R.: Regression models and life-tables. J. R. Stat. Soc. 34: 187-220, 1972.
8. Cunningham, J. M., Ingle, J. N., Jung, S. H., Cha, S. S., Wold, L. E., Farr, G., Witzig, T. E., Krook, J. E., Wieand, H. S. & Kovach, J. S.: p53 gene expression in node-positive breast cancer: relationship to DNA ploidy and prognosis. J. Natl. Cancer Inst. 86: 1871-1873, 1994.
9. Elledge, R. M., Fuqua, S. A. W., Clark, G. M., Pujol, P. and Allred, D. C.: The role and prognostic significance of p53 gene alterations in breast cancer. Breast Cancer Res. Treat. 27: 94-102, 1993.
10. Eyfjörd, J. E., Thorlacius, S., Steinarsdottir, M., Valgardsdottir, R., Ögmundsdottir, H. & Anamthawat-Jonsson, K.: p53 abnormalities and genomic instability in primary human breast carcinomas. Cancer Res. 55: 646-651, 1995.
11. Fisher, C. J., Gillett, C. E., Vojtesek, B., Barnes, D. M. and Millis, R. R.: Problem with p53 immunohistochemical staining: the effect of fixation and variation in the methods of evaluation. Br. J. Cancer 69: 26-31, 1994.
12. Graeber, T. G., Osmanian, C., Jacks, T., Housman, D. E., Cameron, J. K., Lowe, S. W. & Giaccia, A. J.: Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature (Lond.) 379: 88-91, 1994.
13. Greenblatt, M. S., Bennett, W. P., Hollstein, M. & Harris, C. C.: Mutations in the p53 tumour suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res. 54: 4855-4878, 1994.
14. Jacquemier, J., Molés, J. P., Penault-Llorca, F., Adélaide, J., Torrente, M., Viens, P., Birnbaum, D. & Theillet, C.: p53 immunohistochemical analysis in breast cancer with four monoclonal antibodies: comparison of staining and PCR-SSCP results. Br. J. Cancer 69: 846-852, 1994.
15. Kastan, M. B., Onyekwere, O., Sidransky, D., Vogelstein, B. & Craig, R.: Participation of p53 protein in the cellular response to DNA damage. Cancer Res. 51: 6304-6311, 1991.
16. Kuerbitz, S. J., Plunkett, B. S., Walsh, W. V. & Kastan, M. B.: Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc. Natl. Acad. Sci. USA (Wash.) 89: 7491-7495, 1992.
17. Lane, D. P.: p53, guardian of the genome. Nature (Lond.) 358: 15-16, 1992.
18. Livingstone, L. R., White, A., Sprouse, J., Livanos, E., Jacks, T. & Tlsty, T. D.: Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell 70: 923-935, 1992.
19. Lipponen, P., Ji, H., Aaltomaa, S., Syrjänen, S. & Syrjänen, K.: p53 protein expression in breast cancer as related to histopathological characteristics and prognosis. Int. J. Cancer 55: 51-56, 1993.
20. Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A. & Jacks, T.: p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature (Lond.) 362: 847-852, 1993.
21. Lowe, S. C., Bodis, S., McClatchey, A., Remington, L., Ruley, H. E., Fisher, D. E., Housman, D. E. & Jacks, T.: p53 status and the efficacy of cancer therapy in vivo. Science (Wash.) 266: 807-810, 1994.
22. MacGrogan, G., Bonichon, F., De Mascarel, I., Trojani, M., Durand, M., Avril, A. & Coindre, J.-M.: Prognostic value of p53 in breast invasive ductal carcinoma: an immunohistochemical study on 942 cases. Breast Cancer Res. Treat. 36: 71-81, 1995.
23. Moyret, C., Madsen, M. W., Cooke, J., Briand, P. & Theillet, C.: Gradual selection of a cellular clone presenting a mutation at codon 179 of the p53 gene during establishment of the immortalized human breast epithelial cell line HMT-3522. Exp. Cell Res. 215: 380-385, 1994.
24. Prioleau, J. & Schmitt, S. J.: p53 antigen loss in stored paraffin slides. New Engl. J. Med. 332: 1521-1522, 1995.
25. Resnick, J. M., Cherwitz, D., Knapp, D., Uhlman, D. & Niehans, G. A.: A microwave method that enhances detection of aberrant p53 expression in formalin-fixed, paraffin-embedded tissues. Arch. Pathol. Lab. Med. 119: 360-366, 1995.
26. Saitoh, S., Cunningham, J., De Vries, E. M. G., McGovern, R. M., Schroeder, J. J., Hartmann, A., Blaszyk, H., Wold, L. E., Schaid, D., Sommer, S. S. & Kovach, J. S.: p53 gene mutations in breast cancers in mid western US women: null as well as missense-type mutations are associated with poor prognosis. Oncogene 9: 2869-2875, 1994.
27. Shi, S-R., Key, M. E. & Kalra, K. L.: Antigen retrieval in formalin-fixed, paraffin-embedded tissues: An enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections. J. Histochem. Cytochem. 39: 741-748, 1991.
28. Smith-Sörensen, B., Gebhardt, M. C., Kloen, P., Aguilar, F., Friend, S. H. & Borresen, A.-L.: Screening for p53 mutations in osteosarcomas using constant denaturant gel electrophoresis (CDGE). Hum. Mutat. 2: 274-285, 1993.
29. Sommer, S. S., Cunningham, J., McGovern, R. M., Saitoh, S., Schroeder, J. J., Wold, L. E. & Kovach, J. S.: Pattern of p53 gene mutations in breast cancer of women of the midwestern United States. J. Natl. Cancer Inst. 84: 246-252, 1992.
30. Steinarsdottir, M., Petursdottir, I., Snorradottir, S., Eyfjörd, J. E. & Ögmundsottir, H. M.: Cytogenetic studies of breast carcinomas: different karyotypic profiles detected by direct harvesting and short-term culture. Genes Chromosomes. Cancer 13: 239-248, 1995.
31. Thorlacius, S., Borresen, A.-L. & Eyfjörd, J. E.: Somatic p53 mutations in human breast carcinomas in an Icelandic population: a prognosis factor. Cancer Res. 53: 1637-1641, 1993.
32. Thorlacius, S., Thorgilsson, B., Björnsson, J., Tryggvadottir, L., Borresen, A.-L., Ögmundsdsdóttir, H.M. & Eyfjörd, J. E.: TP53 mutations and abnormal TP53 protein staining in breast carcinomas related to prognosis. Eur. J. Cancer 31A/ 11: 1856-1861, 1995.
33. Tulinius, H., Bjarnason, O., Sigvaldason, H., Bjarnadottir, G. & Olafsdottir, G.: Tumours in Iceland. Malignant tumours of the female breast. APMIS 96: 229-238, 1988.
34. Visscher, D. W., Castellani, R., Wykes, S. M., Sarkar, F. H. & Hussain, M. E.: Concurrent abnormal expression of ERBB-2, EGFR, and p53 genes and clinical disease progression of breast carcinoma. Breast Cancer Res. Treat. 28: 261-266, 1993.
35. Wang, X. W., Yeh, H., Schaeffer, L., Roy, R., Moncollin, V., Egly, J.-M., Wang, Z., Friedberg, E. C., Evans, M. K., Taffe, B. G., Bohr, V. A., Weeda, G., Hoeijmakers, J. H. J., Forrester, K. & Harris, C. C.: p53 modulation of TFIIH-associated nucleotide excision repair activity. Nat. Genet. 10: 188-195, 1995.
36. Yin, Y., Tainsky, M. A., Bischoff, F. Z., Strong, L. C. & Wahl, G. M.: Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell 70: 937-948, 1992.