CD5-positive B cells in healthy elderly humans are a polyclonal B cell population

European Journal of Immunology

Volumn 30, Issue 10, 2000, Pages 2918-2923

  Geiger, Kathrin D ^a   Klein, Ulf ^b   Bräuninger, Andreas ^a   Berger, Stefan ^a   Leder, Korinna ^a   Rajewsky, Klaus ^b   Hansmann, Martin Leo ^a   Küppers, Ralf ^b  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

Author keywords

B cell clonality; CD5 B cell; Single cell PCR; Somatic hypermutation; V(H) gene rearrangement

Indexed keywords

CD5 ANTIGEN;

AGED; AGING; ANIMAL CELL; ARTICLE; B CELL LEUKEMIA; B LYMPHOCYTE; BLOOD SAMPLING; CELL CLONING; CELL POPULATION; CELL SELECTION; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; FEMALE; GENE AMPLIFICATION; GENE MUTATION; GENE REARRANGEMENT; HUMAN; HUMAN CELL; LYMPHOCYTE CLONE; MALE; MOUSE; NONHUMAN; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

AGING; ANIMAL; ANTIGENS, CD5; B-LYMPHOCYTE SUBSETS; CLONE CELLS; COMPARATIVE STUDY; DISEASE SUSCEPTIBILITY; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; HUMAN; LEUKEMIA, B-CELL, CHRONIC; MICE; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; SPECIES SPECIFICITY; SUPPORT, NON-U.S. GOV'T;

EID: 0033785538     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200010)30:10<2918::AID-IMMU2918>3.0.CO;2-C     Document Type: Article

References (26)

1. Diagnostic value of clonality of surface immunoglobulin light heavy chains in malignant lymphoproliferative disorders
2. + B cells in autoimmune disease and lymphoid malignancy
3. Molecular single-cell analysis reveals that CD5-positive peripheral blood cells in healthy humans are characterized by rearranged Vκ genes lacking somatic mutation
4. Phenotypic and functional characterization of human Leu1 (CD5) B cells
5. Evidence for a large compartment of IgM-expressing memory B cells in humans
6. + B lymphocytes and the activity of systemic auto-immunity
7. +Ly 1 B clones of (NZBxNZW) F1 mice
8. Ly-1 B cell clones similar to human chronic lymphocytic leukemias routinely develop in older normal mice and young autoimmune (New Zealand Black-related) animals
9. Germline antibody V regions as determinants of clonal persistence and malignant growth in the B cell compartment
10. The 'Ly-1 B' cell subpopulation in normal, immunodefective, and autoimmune mice
11. Cellular basis of B cell clonal populations in old mice
12. + adult B cells are oligoclonal
13. Somatic generation of antibody diversity
14. Automated high resolution PCR fragment analysis for identification of clonally rearranged immunoglobulin heavy chain genes
15. + peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells
16. + B cells
17. Analysis of the human VH gene repertoire
18. + B cells
19. Mechanisms of autoimmune hemolytic anemia in chronic lymphocytic leukemia
20. + B cells in the peritoneal cavity
21. Differential rates of somatic hypermutation in V(H) genes among subsets of chronic lymphocytic leukemia defined by chromosomal abnormalities
22. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors
23. Cellular origin of human B cell lymphomas
24. +B cells, the major B cell subset in the peripheral blood express Vκ genes with no or little somatic mutation throughout life
25. Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells
26. Hodgkin and Reed-Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-derived tumor B cells