Topical treatment of cutaneous chronic graft versus host disease with halofuginone: A novel inhibitor of collagen type I synthesis

Transplantation

Volumn 68, Issue 11, 1999, Pages 1806-1809

  Nagler, Arnon ^a   Pines, Mark ^b  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b VOLCANI CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

HALOFUGINONE;

ADULT; ARTICLE; CASE REPORT; COLLAGEN SYNTHESIS; DRUG SAFETY; GRAFT VERSUS HOST REACTION; HUMAN; MALE; PRIORITY JOURNAL; SKIN FIBROSIS; SKIN TRANSPLANTATION;

EID: 0033572715     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199912150-00027     Document Type: Article

References (9)

1. Sullivan KM, Shulman HM, Storb R, et al. Chronic graft versus host disease in 52 patients: adverse natural course and successful treatment with combination immunosuppression. Blood 1981; 57: 267.
2. DeClerck Y, Draper V, Parkman R. Clonal analysis of murine graft-vs-host disease. II. Leukokines that stimulate fibroblasts proliferation and collagen synthesis in graft-vs-host disease. J Immunol 1986; 136: 3549.
3. Pines M, Nagler A: Halofuginone - A novel antifibrotic therapy. Gen Pharmacol 1997; 30: 445.
4. Pines M, Knopov V, Genina O, Lavelin I, Nagler A. Halofuginone, a specific inhibitor of collagen type I synthesis, prevents dimethylnitrosamine-induced liver cirrhosis: J Hepatol 1998 27: 391.
5. Nagler A, Firman N, Feferman R, Cotev S, Pines M, Shoshan, S. Reduction in pulmonary fibrosis in vivo by halofuginone. Am J Resp Crit Care Med 1996; 154: 1082.
6. Nagler A, Rivkind AI, Raphael J, Levi-Schaffer F, Genina O, Lavelin I. Pines M. Halofuginone - an inhibitor of collagen type I synthesis - prevents post-operation abdominal adhesions formation. Ann Surg 1998; 227: 575.
7. Levi-Schaffer F, Nagler A, Slavin S, Knopov V, Pines M. Inhibition of collagen synthesis and changes in skin morphology in murine graft versus host disease and tight skin mice: effect of halofuginone: J Invest Dermatol 1996; 106: 84.
8. Granot I, Hurwitz S, Halevy O, Pines M. Halofuginone: an inhibitor of collagen type I synthesis. Biochim Biophys Acta 1993; 1156: 107.
9. Halevy O, Nagler A, Levi-Schaffer F, Genina O, Pines M. Inhibition of collagen type I synthesis by skin fibroblasts of graft versus host disease and scleroderma patients: effect of halofuginone. Biochem Pharmacol 1996; 52: 1057.