Halofuginone-an inhibitor of collagen type I synthesis-prevents postoperative formation of abdominal adhesions

Annals of Surgery

Volumn 227, Issue 4, 1998, Pages 575-582

  Nagler, Arnon ^a   Rivkind, Avraham I ^a   Raphael, Jacob ^a   Levi Schaffer, Francesca ^c   Genina, Olga ^b   Lavelin, Irina ^b   Pines, Mark ^b  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b VOLCANI CENTER   (Israel)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; HALOFUGINONE;

ABDOMINAL SURGERY; ANIMAL EXPERIMENT; ARTICLE; COLLAGEN SYNTHESIS; DRUG EFFECT; DRUG EFFICACY; MALE; NONHUMAN; PERITONEUM ADHESION; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; RAT;

ABDOMEN; ADHESIONS; ANIMALS; COLLAGEN; HISTOCYTOCHEMISTRY; IN SITU HYBRIDIZATION; PIPERIDINES; POSTOPERATIVE COMPLICATIONS; PROTEIN SYNTHESIS INHIBITORS; QUINAZOLINES; QUINAZOLINONES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0031928721     PISSN: 00034932     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000658-199804000-00021     Document Type: Article

References (31)

1. Raf LE. Causes of abdominal adhesions in cases of intestinal obstruction. Acta Chir Scand 1969;135:73-76.
2. Menzies D. Postoperative adhesions: their treatment and relevance in clinical practice. Ann Royal Col Surg Engl 1993;75:147-153.
3. Weibel MA, Manjo G. Peritoneal adhesions and their relationship to abdominal surgery. Am J Surg 1973;126:345-353.
4. Monk BJ, Berman ML, Montz FJ. Adhesions after extensive gynecologic surgery: clinical significance, etiology and prevention. Am J Obstet Gynecol 1994;170:1396-1403.
5. Yaffe H, Beyth U, Reinhartz T, Levij IS. Foreign body granulomas in peritubal and periovarian adhesions: a possible cause for unsuccessful reconstructive surgery in fertility. Pert Steril 1980;33:277-279.
6. Hill-West JL, Chowdhury SM, Sawhney AS, et al. Prevention of postoperative adhesion in the rat by in situ photopolymerization of bioresorbable hydrogel barriers. Obstet Gynecol 1994;83:59-64.
7. Sawhney AS, Pathak CP, Hubell JA. Bioerodible hydrogels based on photopolymerized poly (ethylene glycol)-co-poly (alpha) hydroxyacid-diacrylate macromers. Macromolecules 1993;26:581-587.
8. Mahadevan MM, Wiseman D, Leader A, Taylor PJ. The effect of ovarian adhesive disease upon follicular development in cycles of controlled stimulation for in vitro fertilization. Fertil Steril 1985; 44:489-492.
9. Gilmore OJA, Reid C. Prevention of peritoneal adhesions by a new povidone-iodine/PVP solution. J Surg Res 1978;25:477-481.
10. Holtz G, Baker ER. Inhibition of peritoneal adhesion re-formation after lysis with 32% Dextran 70. Fertil Steril 1980;34:394-395.
11. Raferty AT. Effect of peritoneal trauma on peritoneal fibrinolytic activity and intraperitoneal adhesion formation: an experimental study in the rat. Eur Surg Res 1981;13:397-401.
12. Rivkind AI, Lieberman N, Durst AL. Urokinase does not prevent abdominal adhesion formation in rats. Eur Surg Res 1985;17:254-258.
13. Menzies D, Ellis H. Intra-abdominal adhesions and their prevention by topical tissue plasminogen activator. J R Soc Med 1989;82:534-553.
14. Rivkind AI, Marshood M, Durst AL, Becker Y. Cianidanol ([+]-Cynidanol-3) prevents the development of abdominal adhesions in rats. Arch Surg 1983;118:1431-1433.
15. Lai HS, Chu SY, Chen Y, et al. Effect of pentoxifylline on intraperitoneal adhesions after intestinal resection in rats. J Formos Med Assoc 1994;93:911-915.
16. Granot I, Bartov I, Plavnik I, et al. Increased skin tearing in broilers and reduced collagen synthesis in skin in vivo and in vitro in response to the coccidiostat halofuginone. Poultry Sci 1991;70:1559-1563.
17. Levi-Schaffer F, Nagler A, Slavin S, et al. Inhibition of collagen synthesis and changes in skin morphology in murine graft-versus-host disease and tight skin mice: Effect of halofuginone. J Invest Dermatol 1996;106:84-88.
18. Nagler A, Firman N, Feferman R, et al. Reduction in pulmonary fibrosis in vivo by halofuginone. Am J Resp Critical Care Med 1996; 154:1082-1086.
19. Pines M, Knopov V, Genina O, et al. Halofuginone, a specific inhibitor of collagen type I synthesis, prevents dimethylnitrosamine-induced liver cirrhosis. J Hepatol 1977;26:391-398.
20. Nyska M, Nyska A, Rivlin E, et al. Topically applied halofuginone, an inhibitor of collagen type I transcription, reduced peritendinous fibrous adhesions following surgery. Conn Tissue Res 1996;34:97-103.
21. Granot I, Hurwitz S, Halevy O, Pines M. Halofuginone: an inhibitor of collagen type I synthesis. Biochim Biophys Acta 1993;1156:107-112.
22. Halevy O, Nagler A, Levi-Schaffer F, et al. Inhibition of collagen type I synthesis by skin fibroblasts of graft versus host disease and scleroderma patients: effect of halofuginone. Biochem Pharmacol 1996; 52:1057-1063.
23. Choi ET, Callow AD, Sehgal NL, et al. Halofuginone, a specific collagen type I inhibitor, reduces anastomotic intima hyperplasia. Arch Surg 1995;130:257-261.
24. Gascon-Barre M, Huet PM, Belgiorno J, et al. Estimation of collagen content of liver specimens. Variation among animals and among hepatic lobes in cirrhotic rats. J Histochem Cytochem 1989;37:377-381.
25. Pines M, Knopov V, Bar A. Involvement of osteopontin in egg shell formation in the laying chicken. Matrix Biology 1996;14:765-771.
26. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate phenol chloroform extraction. Anal Biochem 1987;162:156-159.
27. Harrop AR, Ghahary A, Scott PG, et al. Regulation of collagen synthesis and mRNA expression in normal and hypertrophic scar fibroblasts in vitro by interferon-γ. J Surg Res 1995;58:471-477.
28. Iijima N, Yamamoto T, Inome K. Prevention of intraabdominal adhesions by protoporphyrin: an experimental study. Jpn J Exp Med 1969; 39:311-319.
29. Ellis H. The cause and prevention of intestinal adhesions. Br J Surg 1982;69:241-243.
30. Ellis H. Intraperitoneal adhesions. Br J Hosp Med 1974;11:401-410.
31. Ryan CK, Sax HC. Evaluation of a carboxymethylcellulose sponge for prevention of postoperative adhesions. Am J Surg 1995;169: 154-160.