The catalytic DNA topoisomerase II inhibitor dexrazoxane (ICRF-187) induces endopolyploidy in Chinese hamster ovary cells

Journal of Pharmacology and Experimental Therapeutics

Volumn 295, Issue 2, 2000, Pages 474-483

  Hasinoff, B B ^a   Abram, M E ^a   Chee, G L ^a   Huebner, E ^a   Byard, E H ^a   Barnabe, N ^a   Ferrans, V J ^a   Yu, Z X ^a   Yalowich, J C ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TUBULIN; F ACTIN; GYRASE INHIBITOR; RAZOXANE;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL SIZE; CHO CELL; CONTROLLED STUDY; CYTOKINESIS; DNA STRAND BREAKAGE; DRUG MECHANISM; ENZYME INACTIVATION; ENZYME LOCALIZATION; ENZYME MECHANISM; NONHUMAN; POLYPLOIDY; PRIORITY JOURNAL;

ANIMAL; ANTINEOPLASTIC AGENTS; CATALYSIS; CELL DIVISION; CHO CELLS; DNA; DNA TOPOISOMERASES, TYPE II; ENZYME INHIBITORS; HAMSTERS; KINETICS; MICROSCOPY, ELECTRON; MICROSCOPY, FLUORESCENCE; POLYPLOIDY; RAZOXANE; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0033781968     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Augmentation of the number of nucleolar organizer regions in human megakaryocyte cell lines after induction of polyploidization by a microtubule inhibitor
2. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
3. Stability of nuclear segments in human neutrophils and evidence against a role for microfilaments or microtubules in their genesis during differentiation of HL60 myelocytes
4. Improved microfluorometric DNA determination in biological material using 33258 Hoechst
5. Is DNA topoisomerase IIβ a nucleolar protein?
6. When good enzymes go bad: Conversion of topoisomerase II to a cellular toxin by antineoplastic drugs
7. Biochemical studies on growth-inhibitory bisdioxopiperazines. I. Effect on DNA, RNA and protein synthesis in mouse-embryo fibroblasts
8. A topoisomerase II-dependent G2 cycle checkpoint in mammalian cells
9. ICRF 159-induced cell-cycle perturbation in vitro: Its relationship to inhibition of colony-forming ability
10. Cell cycle regulation of DNA replication: The endoreduplication perspective
11. Dynamics of chromosomes and microtubules visualized by multiple-wavelength fluorescence imaging in living mammalian cells: Effects of mitotic inhibitors on cell cycle progression
12. Chemistry of dexrazoxane and analogues
13. The cardioprotective and DNA topoisomerase II inhibitory agent dexrazoxane (ICRF-187) antagonizes the camptothecin-mediated growth inhibition of Chinese hamster ovary cells by inhibition of DNA synthesis
14. Chemical, biological and clinical aspects of dexrazoxane and other bisdioxopiperazines
15. Characterization of a Chinese hamster ovary cell line with acquired resistance to the bisdioxopiperazine dexrazoxane (ICRF-187) catalytic inhibitor of topoisomerase II
16. A QSAR study comparing the cytotoxicity and DNA topoisomerase II inhibitory effects of bisdioxopiperazine analogs of ICRF-187 (dexrazoxane)
17. The effect of dexrazoxane (ICRF-187) on doxorubicin- and daunorubicin-mediated growth inhibition of Chinese hamster ovary cells
18. Effect of ICRF 159 on the mammalian cell cycle: Significance for its use in cancer chemotherapy
19. Pharmacokinetics of the cardioprotector ADR-529 (ICRF-187) in escalating doses combined with fixed-dose doxorubicin
20. Inhibition of intracellular topoisomerase II by antitumor bis(2,6-dioxopiperazine) derivatives: Mode of cell growth inhibition distinct from that of cleavable complex-forming type inhibitors
21. Inhibition of DNA topoisomerase II by ICRF-193 induces polyploidization by uncoupling chromosome dynamics from other cell cycle events
22. ICRF-193, a catalytic inhibitor of DNA topoisomerase II, delays the cell cycle progression from metaphase, but not from anaphase to the G1 phase in mammalian cells
23. A novel mechanism of cell killing by anti-topoisomerase II bisdioxopiperazines
24. 2-terminal kinase 1 (JNK1) activation in VM-26-resistant CEM cells
25. Cell line-specific differences in the control of cell cycle progression in the absence of mitosis
26. The significance of megakaryocyte size
27. Phorbol ester-induced down-regulation of topoisomerase IIα mRNA in a human erythroleukemia cell line
28. Induction of apoptosis in oxygen-deprived cultures of hybridoma cells
29. 2/M checkpoint and apoptotic responses
30. Thrombopoietin-induced polyploidization of bone marrow megakaryocytes is due to a unique regulatory mechanism in late mitosis
31. Retinoic acid induction of nuclear envelope-limited chromatin sheets in HL-60
32. Differentiation of U-937 promonocytic cells by etoposide and ICRF-193, two anti-tumour DNA topoisomerase II inhibitors with different mechanisms of action
33. Inverse relationship between catenation and superhelicity in newly replicated simian virus 40 daughter chromosomes
34. Centrosomes, and not nuclei, initiate pole cell formation in Drosophila embryos
35. Antitumor bisdioxopiperazines inhibit yeast DNA topoisomerase II by trapping the enzyme in the form of a closed protein clamp
36. Antagonistic effect of the cardioprotector (+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane (ICRF-187) on DNA breaks and cytotoxicity induced by the topoisomerase II directed drugs daunorubicin and etoposide (VP-16)
37. Mechanism of action studies with ICRF 159: Effects on the growth and morphology of BHK-21S cells
38. Antineoplastic activity of continuous exposure to dexrazoxane: Potential new role as a novel topoisomerase II inhibitor
39. Effects of the L isomer (+)-1,2-bis(3,5-dioxopiperazine-1-yl)propane on cell survival and cell cycle progression of cultured mammalian cells
40. Human small cell lung cancer NYH cells selected for resistance to the bisdioxopiperazine topoisomerase II catalytic inhibitor ICRF-187 demonstrate a functional R162Q mutation in the Walker A consensus ATP binding domain of the alpha isoform
41. Acquired resistance to ICRF-187 (dexrazoxane) in a CHO cell line is associated with a point mutation in DNA topoisomerase IIα (topo II) and decreased drug-induced DNA-enzyme complexes
42. Effect of storeoisomers related to ICRF-159 on metastasis or B16 melanoma