Differentiation of U-937 promonocytic cells by etoposide and ICRF-193, two antitumour DNA topoisomerase II inhibitors with different mechanisms of action

Journal of Cell Science

Volumn 110, Issue 3, 1997, Pages 337-343

  Pérez, Concepción ^a,b   Vilaboa, Nuria E ^a   García Bermejo, Laura ^a,c   De Blas, Elena ^a   Creighton, Andrew M ^d   Aller, Patricio ^a  

^a CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^b INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^c UNIVERSITY OF ALCALÁ   (Spain)

^d ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

Apoptosis; Differentiation; Etoposide; ICRF 193; Topoisomerase II inhibition; U 937 cell

Indexed keywords

ETOPOSIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN KINASE C; TRANSCRIPTION FACTOR;

APOPTOSIS; ARTICLE; CELL CYCLE G2 PHASE; CELL DIFFERENTIATION; DNA STRAND BREAKAGE; ENZYME ACTIVATION; LEUKEMIA CELL LINE; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL DIFFERENTIATION; DNA DAMAGE; DNA TOPOISOMERASES, TYPE II; DNA-BINDING PROTEINS; EARLY GROWTH RESPONSE PROTEIN 1; ENZYME ACTIVATION; ENZYME INHIBITORS; ETOPOSIDE; HUMANS; IMMEDIATE-EARLY PROTEINS; MONOCYTES; NF-KAPPA B; PIPERAZINES; PROTEIN KINASE C; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 0342460503     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Aihara, H., Asaoka, Y., Yoshida, K. and Nishikuza, Y. (1991). Sustained activation of protein kinase C is essential to HL-60 cell differentiation to macrophage. Proc. Nat. Acad. Sci. USA 88, 11062-11066.
2. Aller, P., Rius, C., Mata, F., Zorrilla, A., Cabanas, C., Bellón, T. and Bernabeu, C. (1992). Camptothecin induces differentiation and stimulates the expression of differentiation-related genes in U-937 human promonocytic leukemia cells. Cancer Res. 52, 1245-1251.
3. Ballester, A., Pérez, C., Aller, P. and Mata, F. (1996). Differentiation of U-937 promonocytic cells with mitomycin C or cis-diamminedichloroplatinium II. Int. J. Cancer 65, 791-795.
4. Beere, H. M., Chresta, C. M. and Hickman, J. A. (1996). Selective inhibition of topoisomerase II by ICRF-193 does not support a role for topoisomerase II activity in the fragmentation of chromatin during apoptosis of human leukemia cells. Mol. Pharmacol. 49, 842-851.
5. Bertrand, R., Solary, E., Jenkins., J. and Pommier, Y. (1993). Apoptosis and its modulation in human promyelocytic cells treated with DNA topoisomerase I and II inhibitors. Exp. Cell Res. 207, 388-397.
6. Bessho, R., Matsubara, K., Kubota, M., Kuwakado, K., Hirota, H., Wakazono, Y., Lin, Y. W., Okuda, A., Kawai, M., Nishikomori, R. and Heike, T. (1994). Pyrrolidone dithiocarbamate, a potent inhibitor of nuclear factor κB (NF-κB) activation, prevents apoptosis in human promyelocytic leukemia HL-60 cells and thymocyles. Biochem. Pharmacol 48, 1883-1889.
7. Brach, M. A., Hass, R., Sherman, M. L., Gunji, H., Weichselbaum, R. and Kufe, D. (1991). Ionizing radiation induces expression and binding activity of the nuclear factor κB. J. Clin. Invest. 88, 691-695.
8. Collins, S. J. (1987). The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression. Blood 70, 1233-1244.
9. Collins, S. J., Bodner, A., Ting, R. and Gallo, R. C. (1980). Induction of morphological and fuctional differentiation of human promyelocytic leukemia cells (HL60) by compounds which induce cell differentiation. Int. J. Cancer 25, 213-218.
10. Constantinou, A., Henning-Chubb, C. and Huberman, E. (1989). Novobiocin-and phorbol-12-myristate-13-acetate-induced differentiation of human leukemia cells associated with a reduction of topoisomerase II activity. Cancer Res. 49, 1110-1117.
11. Constantinou, A., Grdina, D., Kiguchi, K. and Huberman, E. (1992). The effect of topoisomerase inhibitors on the expression of differentiation markers and cell cycle progression in K-562 human leukemia cells. Exp. Cell Res. 203, 100-105.
12. Cotter, T. G., Fernandes, R. S., Verhaegen, S. and McCarthey, J. V. (1994). Cell death in the myeloid lineage. Immunol. Rev. 142, 93-112.
13. D'Arpa, P. and Liu, L. F. (1989). Topoisomerase-targeting antitumor drugs. Biochim. Biophys. Acta 989, 163-177.
14. Dudley, D., Baker, D. M., Hickey, M. J. and Hickstein, D. D. (1989). Expression of surface antigen and mRNA for the CD11c (aX, p150) subunit of the human leukocyte adherence receptor family in hematopoietic cells. Biochem. Biophys. Res. Commun. 160, 346-353.
15. Durkin, J. P., Chakravarky, B., Tremblay, R., Jouishomme, H., Whitfield, J. F., Biquard, J. M. and Krsmanovic, V. (1992). Evidence that a novel human differentiation-inhibiting protein blocks the dimethyl sulfoxide-induced differentiation of erythroleukemia cells by inhibiting the activation of membrane protein kinase C. Cancer Res. 52, 6329-6334.
16. Hallahan, D. E., Sukhatme, V. P., Sherman, M. L., Virudachalam, S., Kufe, D. and Weichselbaum, R. R. (1991). Protein kinase C mediates x-ray inducibility of nuclear signal transducers EGR1 and JUN. Proc. Nat. Acad. Sci. USA 88, 2156-2160.
17. Hass, R., Brach, M., Gunji, H., Kharbanda, S. and Kufe, D. (1992). Inhibition of EGR and NF-κB gene expression by dexamethasone during phorbol ester-induced human monocytic differentiation. Biochem. Pharmacol. 44, 1569-1576.
18. Hickstein, D. D., Back, A. L. and Collins, S. J. (1989). Regulation of expression of the CD11b and CD18 subunits of the neutrophil adherence receptor during human myeloid differentiation. J. Biol. Chem. 264, 346-353.
19. Ishida, R., Miki, T., Narita, T., Yui, R., Sato, M., Utsumi, K. R., Tanabe, K. and Andoh, T. (1991). Inhibition of intracellular topoisomerase II by antitumor bis(2,6-dioxopiperazine) derivatives: Mode of cell growth inhibition distinct from that of cleavable complex-forming type inhibitors. Cancer Res. 51, 4909-4916.
20. Ishida, R., Sato, M., Narita, T., Utsumi, K. R., Nishimoto, T., Morita, T., Nagata, H. and Andoh, T. (1994). Inhibition of DNA topoisomerse II by ICRF-193 induces polyploidization by uncoupling chromosome dynamics from other cell cycle events. J. Cell Biol. 126, 1341-1351.
21. Kohn, K. W., Ewing, R. A. G., Erickson, L. C. and Zwelling, L. A. (1981). Measurement of strand breaks and cross-links by alkaline elution, in DNA Repair: A Laboratory Manual of Research Procedures (ed. R. C. Friedberg and P. C. Hasnawalt). pp. 379-401. Marcel Dekker, New York.
22. Kondo, K., Tsuneizumi, K., Watanabe, T. and Oishi, M. (1991). Induction of in vitro differentiation of mouse embryonal carcinoma (F) cells by inhibitors of topoisomerases. Cancer Res. 51, 5398-5404.
23. Kung, A. L., Zetterberg, A., Sherwood, S. W. and Schimke, R. T. (1990). Cytotoxic effects of cell cycle phase specific agents: results of cell cycle perturbation. Cancer Res. 50, 7307-7317.
24. Larcher, J. C., Cordeau-Lossauarn, L., Romey, G., Gros, F., Croizat, B. and Vayssiere, J. L. (1992). Adriamycin promotes neurite outgrowth in the 'neurite-minus' N1A-103 mouse neuroblastoma cell line. Exp. Cell Res. 203, 72-79.
25. Makowske, M., Ballester, R., Cayres, Y. and Rosen, O. M. (1988). Immunochemical evidence that three protein kinase C isozymes increase in abundance during HL-60 differentiation induced by dimethyl sulfoxide and retinoic acid. J. Biol. Chem. 263, 3402-3410.
26. Mata, F., Rius, C., Cabañas, C., Bernabeu, C. and Aller, P. (1989). S-phase inhibitors induce vimentin expression in human promonocytic cells. FEBS Lett. 259, 171-194.
27. Mezetti, G., Bagnara, G. P., Monti, M. G., Casolo, L. P., Bonsi, L. and Brunelli, M. A. (1987). Phorbol esters, but not the hormonal form of vitamin D, induce changes in protein kinase C during differentiation of human histiocytic lymphoma cell line (U-937). Life Sci. 40, 2111-2117.
28. Nakaya, K., Chou, S., Kaneko, M. and Nakamura, Y. (1991). Topoisomerase inhibitors have potent differentiation-inducing activity for human and mouse myeloid leukemia cells. Jpn J. Cancer Res. 82, 184-191.
29. Pérez, C., Campayo, L., Navarro, P., García-Bermejo, L. and Aller, P. (1994). The action of the DNA intercalating agents 4′(9-acridinylamino)methanesulfon-m-anisidide and 1,4-bis(butylamino)benzo[g]phthalazine in U-937 human promonocytic cells: relationship between cell growth and differentiation. Biochem. Pharmacol. 48, 75-82.
30. Posada, J., Vici, P. and Tritton, T. (1989). Protein kinase C in adriamycin action and resistance in mouse sarcoma 180 cells Cancer Res. 49, 6634-6639.
31. + monomyelocytic leukemia cells by inhibitors of topoisomerase II. Cancer Res. 50, 6723-6730.
32. Rius, C., Zorrilla, A., Cabañas, C., Mata, F., Bernabeu, C. and Aller, P. (1991). Differentiation of human promonocytic leukemia U-937 cells with DNA topoisomerase II inhibitors: Induction of vimentin gene expression. Mol. Pharmacol. 39, 442-448.
33. Rius, C. and Aller, P. (1992). Vimentin expression as a late event in the in vitro differentiation of human promonocytic cells. J. Cell Sci. 101, 395-401.
34. Roca, J., Ishida, R., Berger, J. M., Andoh, T. and Wang., J. (1994). Antitumor bisdioxopiperazines inhibit yeast DNA topoisomerase II by trapping the enzyme in the form of closed protein clamp. Proc. Natl. Acad. Sci. USA 91, 1781-1785.
35. Rubin, E., Kharbanda, S., Gunji, H. and Kufe. D. (1991). Activation of the c-jun protooncogene in human myeloid leukemia cells treated with etoposide. Mol. Pharmacol. 39, 697-701.
36. Rubin, E., Kharbanda, S., Gunji, H., Weichselbaum, R. and Kufe, D. W. (1992). cis-Diamminechloroplatinium (II) induces c-jun expression in human myeloid leukemia cells: potential involvement of a protein kinase C-dependent signalling pathway. Cancer Res. 52, 878-882.
37. Rubin, L. L., Philipott, K. L. and Brooks, S. F. (1993). The cell cycle and cell death. Current Biol. 3, 391-394.
38. Sambrook, J., Fritsch, E. F. and Maniatis, T. (1989). Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
39. Schreibert, E., Mathias, P., Müller, M. M. and Schaffner, W. (1988). Identification of a novel lymphoid specific octamer binding protein (OTF-2B) by proteolytic bandshift assay (PCBA). EMBOJ. 7, 4221-4229.
40. Sundstrom, C. and Nilsson, K. (1976). Establishment and characterization of a human hystiocytic lymphoma cell line (U-937). Int. J. Cancer 17, 565-577.
41. Tanabe, K., Ikegami, Y., Ishida, R. and Andoh, T. (1991). Inhibition of topoisomerase II by antitumour agent Bis(2, 6-dioxopiperazine) derivatives. Cancer Res. 51, 4903-4908.
42. Vosberg, H. P. (1985). DNA topoisomerases: enzymes that control DNA conformation. Curr. Top. Microbiol. Immunol. 114, 19-102.
43. Wangenheim, K. H. and Howard, A. (1978). Different modes of cell sterilization: cell killing and early differentiation. Radiat. Res. 73, 288-302.
44. Yasuda, I., Kishimoto, A., Tanaka, S. I., Tominaga, M., Sakuri, A. and Nishizuka, Y. A. (1990). A synthetic peptide substrate for selective assay of protein kinase C. Biochem. Biophys. Res. Commun. 166, 1220-1227.