Effects of halothane on the transient outward K+ current in rat ventricular myocytes

British Journal of Pharmacology

Volumn 131, Issue 2, 2000, Pages 223-230

  Davies, Lucinda A ^a   Hopkins, Philip M ^a   Boyett, Mark R ^a   Harrison, Simon M ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

Action potential; Halothane; Heart; Potassium current; Volatile anaesthetics

Indexed keywords

4 AMINOPYRIDINE; CADMIUM; CALCIUM ION; EGTAZIC ACID; HALOTHANE; INHALATION ANESTHETIC AGENT; NIFEDIPINE; POTASSIUM ION; SODIUM ION;

ANIMAL CELL; ANIMAL TISSUE; ARRHYTHMOGENESIS; ARTICLE; CALCIUM CURRENT; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; HEART MUSCLE POTENTIAL; HEART MUSCLE REFRACTORY PERIOD; HEART VENTRICLE WALL; MALE; MINIMUM LUNG ALVEOLUS CONCENTRATION; MUSCLE CELL; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; SODIUM CURRENT;

EID: 0033778984     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703565     Document Type: Article

References (44)

1. NMR structure of inactivation gates from mammalian voltage-dependent potassium channels
2. Heterogeneity within the ventricular wall: Electrophysiology and pharmacology of epicardial, endocardial and M cells
3. Mechanisms for cardiac dysrhythmias during anesthesia
4. Effects of halothane on transmembrane potentials, calcium transients and papillary muscle tension in the cat
5. The effects of halothane, enflurane and isoflurane on calcium current in isolated canine ventricular cells
6. Effects of halothane and isoflurane on calcium and potassium channel currents in canine coronary arterial cells
7. A novel experimental chamber for single-cell voltage-clamp and patch-clamp applications with low electrical noise and excellent temperature and flow control
8. Properties of the transient outward current in rabbit atrial cells
9. Existence of two transient outward currents in sheep cardiac Purkinje fibres
10. + channels are differentially modified by general anesthetics
11. + current in rat ventricular myocytes
12. + conduction and selectivity
13. - dependence
14. + channels in dog cerebral arterial muscle cells
15. The effects of volatile anaesthetics on L- and T-type calcium channel currents in canine cardiac Purkinje cells
16. The effects of halothane and isoflurane on slowly inactivating sodium current in canine cardiac Purkinje cells
17. Molecular mechanisms of general anaesthesia
18. Temperature dependence of the potency of volatile general anaesthetics
19. + channel: Potential sites of interaction with the protein
20. + channel
21. Mechanisms underlying the inotropic action of halothane on intact rat ventricular myocytes
22. Effects of halothane and isoflurane on rat ventricular action potentials recorded in situ
23. Biophysical and molecular mechanisms of Skaker potassium channel inactivation
24. Comparative effects of halothane, enflurane and isoflurane at equipotent anaesthetic concentrations on isolated ventricular myocardium of the ferret I. Contractility
25. Comparative effects of halothane, enflurane and isoflurane at equipotent anaesthetic concentrations on isolated ventricular myocardium of the ferret II. Relaxation
26. Reduction of the slow inward current of isolated rat ventricular cells by thiamylal and halothane
27. Early outward current in rat single ventricular cells
28. 4-Aminopyridine and the early outward current of sheep cardiac Purkinje fibres
29. Depressant effects of isoflurane and halothane on isolated human atrial fibres
30. Characteristics of transient outward current in human ventricular myocytes from patients with terminal heart failure
31. Effects of halothane and enflurane on conduction velocity and maximum rate of rise of action potential upstroke in guinea-pig papillary muscles
32. 2+ channel current in guinea-pig myocytes
33. Actions of halothane, isoflurane and enflurane on the regional action potential characteristics of canine Purkinje fibres
34. Effects of propofol and enflurane on action potentials, membrane currents and contraction of guinea-pig isolated ventricular myocytes
35. 2+](i)-dependent chloride current in single Purkinje cells from rabbit heart
36. Left ventricular function in conscious man and during halothane anaesthesia
37. 2+ in rat and human ventricular myocytes
38. + current in canine cardiac Purkinje cells
39. Influence of halothane on electrical coupling in cell pairs isolated from guinea-pig ventricle
40. Effects of halothane on membrane currents associated with contraction in myocytes isolated from guinea-pig ventricle
41. Voltage-dependent effects of volatile anaesthetics on cardiac sodium current
42. Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived from ShB
43. Halothane acts on many potassium channels, including a minimal potassium channel
44. Calcium-activated chloride current in rabbit ventricular myocytes